High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors

Brain Pathology

Volumn 9, Issue 3, 1999, Pages 463-467

  Hayes, Vanessa M ^a   Dirven, Clemens M F ^a   Dam, Anke ^a   Verlind, Edwin ^a   Molenaar, Willemina M ^a   Mooij, Jan Jakob A ^a   Hofstra, Robert M W ^a   Buys, Charles H C M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PROTEIN TP 53; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; ASTROCYTOMA; CARCINOGENESIS; CLINICAL ARTICLE; DENATURING GRADIENT GEL ELECTROPHORESIS; GENE MUTATION; GENETIC ANALYSIS; GENETIC CODE; HUMAN; INFANT; MISSENSE MUTATION; MOLECULAR DYNAMICS; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

EID: 0033016982     PISSN: 10156305     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3639.1999.tb00535.x     Document Type: Article

References (27)

1. Bogler O, Huang HJS, Kleihues P, Cavenee W (1995) The p53 gene and its role in human brain tumours. GLIA 15: 308-327
2. Felix CA, Slavc I, Dunn M, Strauss EA, Phillips PC, Rorke LB, Sutton L, Bunin GR, Biegel JA (1995) p53 gene mutations in pediatric brain tumours. Med Pediat Oncol 25: 431-436
3. Felley-Bosco E, Weston A, Cawley HM, Bennett WP, Harris CC (1993) Functional studies of a germ-line polymorphism at codon 47 within the p53 gene. Am J Hum Genet 53: 752-759
4. Giannini C, Scheithauer BW (1997) Classification and grading of low-grade astrocytic tumors in children. Brain Pathol 7: 785-798
5. Gilles FH, Leviton A, Hedley-White ET, Sobel E, Tavare CJ, Sobel RS, Rorke LB (1992) Childhood brain tumors that occupy more than one compartment at presentation. J Neurooncol 14: 45-56
6. Hayes VM, Bleeker W, Verlind E, Timmer T, Karrenbeld A, Plukker JT, Marx MP, Hofstra RMW, Buys CHCM. A comprehensive TP53-denaturing gradient gel electrophoresis assay also applicable to archival paraffin-embedded tissue. Diagn Mol Pathol, in press
7. Hebsgaard SM, Korning PG, Tolstrup N, Engelbrecht J, Rouze P, Brunak S (1996) Splice site prediction in Arabidopsis thaliana DNA by combining local and global sequence information. Nucleic Acids Res 24: 3439-3452
8. Hollstein M, Sidransky D, Vogelstein B, Harris CC (1991) p53 mutations in human cancers. Science 253: 49-53
9. Hollstein M, Shomer B, Greenblatt M, Soussi T, Hovig E, Montesano R, Harris CC (1996) Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation. Nucl Acids Res 24: 141-146
10. Hunter SB, Bandea C, Swan D, Abbott K, Varma A. (1993) Mutations in the p53 gene in human astrocytomas: Detection by single-stranded conformation polymorphism analysis and direct DNA sequencing. Mod Pathol 6: 442-445
11. Lamb P, Crawford LV (1986) Characterization of the human p53 gene. Mol Cell Biol 6: 1379-1385
12. Lang FF, Miller DC, Pisharody S, Koslow M, Newcomb EW (1994) High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas. Oncogene 9: 949-954
13. Levine AJ, Momand J, Finlay CA (1991) The p53 tumour supressor gene. Nature 351: 453-456
14. Litofsky NS, Hinton D, Raffel C (1994) The lack of a role for p53 in astrocytomas in pediatric patients. Neurosurgery 34: 967-973
15. Louis DN (1994) The p53 gene and protein in human brain tumors. J Neuropathol Exp Neurol 53: 11-21
16. Matlashewski GJ, Tuck S, Pim D, Lamb P, Schneider J, Crawford LV (1987) Primary structure polymorphism at amino acid residue 72 of human p53. Mol Cell Biol 7: 961-963
17. Mashiyama S, Murakami Y, Yoshimoto T, Sekiya T, Hayashi K (1991) Detection of p53 gene mutations in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction products. Oncogene 6: 1313-1318
18. Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, Bigner SH, Davidson N, Baylin S, Devilee P, Glover T, Collins FS, Weston A, Modali R, Harris CC, Vogelstein B (1989) Mutations in the p53 gene occur in diverse human tumor types. Nature 342: 705-708
19. Ohgaki H, Eibl RH, Schwab M, Reichel MB, Mariani L, Gehring M, Petersen I, Hoell T, Wiestler OD, Kleihues P (1993) Mutations of the p53 suppresser gene in neoplasms of the human nervous system. Mol Carcinogen 8: 74-80
20. Patt S, Gries H, Giraldo M, Cervos-Navarro J, Martin H, Janisch W, Brockmoller J (1996) p53 gene mutations in human astrocytic brain tumors including pilocytic astrocytomas. Hum Pathol 27: 586-589
21. Rasheed BKA, McLendon RE, Herndon JE, Friedman HS, Friedman AH, Bigner DD, Bigner SH. Alterations of the TP53 gene in human gliomas (1994) Cancer Res 54: 1324-1330
22. Scheffield VC, Beck JS, Kwitek AE, Sandstrom DW, Stone EM (1993) The sensitivity of single-strand conformation polymorphism analysis for the detection of single base substitutions (1993) Genomics 16: 325-332
23. Schiffer D, Cavalla P, Di Sapio A, Giordana MT, Mauro A (1995) Mutations and immunohistochemistry of p53 and proliferation markers in astrocytic tumors of childhood. Child's Nerv Syst 11: 517-522
24. Stein A, Raoult D (1992) A simple method for amplification of DNA from paraffin-embedded tissue. Nucleic Acids Res 20: 5237-5238
25. Vogelstein B, Kinzler KW (1992) p53 finction and dysfunction. Cell 70: 523-526
26. von Deimling A, Louis DN, Menon AG, von Ammon K, Peterson I, Ellison D, Wiestler OD, Seizinger BR (1993) Deletions on the long arm of chromosome 17 in pilocytic astrocytoma. Acta Neuropathol 86: 81-85
27. Watanabe K, Tachibana O, Sato K, Yonekawa Y, Kleihues P, Ohgaki H (1996) Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol 6: 217-224