Inhibition of experimental sjögren's syndrome through immunization with Hsp60 and its peptide amino acids 437-460

Arthritis and Rheumatism

Volumn 58, Issue 8, 2008, Pages 2318-2328

  Delaleu, Nicolas ^a   Madureira, Ana Carina ^a   Immervoll, Heike ^a,b   Jonsson, Roland ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIBODY; EOTAXIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE CHEMOTACTIC PROTEIN 2; HEAT SHOCK PROTEIN 60; IMMUNOGLOBULIN G1; INTERLEUKIN 10; LEPTIN; MUSCARINIC M3 RECEPTOR ANTIBODY; STRESSGEN; VALYLGLUTAMYLGLYCYLGLYCYLGLYCYLVALYLALANYLLEUCYLLEUCYLARGINYLVALYL ISOLEUCYLPROLYLALANYLLEUCYLASPARTYLSERYLLEUCYLTHREONYLPROLYLALANYL ASPARAGINYLGLUTAMYLASPARTIC ACID; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXOCRINE GLAND; FEMALE; HISTOPATHOLOGY; HYPOSALIVATION; IMMUNIZATION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; SALIVA; SERUM; SIALOADENITIS; SJOEGREN SYNDROME;

AMINO ACIDS; ANIMALS; BIOLOGICAL MARKERS; CHAPERONIN 60; CHEMOKINE CCL11; CHEMOKINE CXCL6; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; FEMALE; INSULIN; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; PEPTIDES; PYRIMIDINONES; SALIVA; SJOGREN'S SYNDROME; THIAZOLES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 49049110354     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.23656     Document Type: Article

References (49)

1. Shoda LK, Young DL, Ramanujan S, Whiting CC, Atkinson MA, Bluestone JA, et al. A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity 2005;23:115-26.
2. Srivastava P. Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. Annu Rev Immunol 2002;20:395-425.
3. Kamphuis S, Albani S, Prakken BJ. Heat-shock protein 60 as a tool for novel therapeutic strategies that target the induction of regulatory T cells in human arthritis. Expert Opin Biol Ther 2006;6:579-89.
4. Wick G. The heat is on: heat-shock proteins and atherosclerosis [editorial]. Circulation 2006;114:870-2.
5. Elias D, Markovits D, Reshef T, van der Zee R, Cohen IR. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc Natl Acad Sci U S A 1990;87:1576-80.
6. Huurman VA, Decochez K, Mathieu C, Cohen IR, Roep BO. Therapy with the hsp60 peptide DiaPep277 in C-peptide positive type 1 diabetes patients. Diabetes Metab Res Rev 2007;23:269-75.
7. Elias D, Reshef T, Birk OS, van der Zee R, Walker MD, Cohen IR. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci U S A 1991;88:3088-91.
8. Nussbaum G, Zanin-Zhorov A, Quintana F, Lider O, Cohen IR. Peptide p277 of HSP60 signals T cells: inhibition of inflammatory Chemotaxis. Int Immunol 2006;18:1413-9.
9. Zanin-Zhorov A, Nussbaum G, Franitza S, Cohen IR, Lider O. T cells respond to heat shock protein 60 via TLR2: activation of adhesion and inhibition of chemokine receptors. FASEB J 2003;17:1567-9.
10. + regulatory T cell function via innate TLR2 signaling. J Clin Invest 2006;116:2022-32.
11. Zanin-Zhorov A, Bruck R, Tal G, Oren S, Aeed H, Hershkoviz R, et al. Heat shock protein 60 inhibits Th1-mediated hepatitis model via innate regulation of Th1/Th2 transcription factors and cytokines. J Immunol 2005;174:3227-36.
12. Binder RJ, Vatner R, Srivastava P. The heat-shock protein receptors: some answers and more questions. Tissue Antigens 2004;64:442-51.
13. Delaleu N, Jonsson R, Koller MM. Sjögren's syndrome. Eur J Oral Sci 2005;113:101-13.
14. Jonsson R, Bowman SJ, Gordon T. Sjögren's syndrome. In: Koopman W, editor. Arthritis and allied conditions: a textbook of rheumatology. 15th ed. Philadelphia: Lippencott William & Wilkins; 2005. p. 1681-706.
15. Delaleu N, Jonsson MV, Jonsson R. Disease mechanisms of Sjögren's syndrome. Drug Discov Today 2004;1:329-36.
16. null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjögren's syndrome. Proc Natl Acad Sci U S A 1998;95:7538-43.
17. Yokota S, Minota S, Fujii N. Anti-HSP auto-antibodies enhance HSP-induced pro-inflammatory cytokine production in human monocytic cells via Toll-like receptors. Int Immunol 2006;18:573-80.
18. Yannopoulos DI, Roncin S, Lamour A, Pennec YL, Moutsopoulos HM, Youinou P. Conjunctival epithelial cells from patients with Sjögren's syndrome inappropriately express major histocompatibility complex molecules, La(SSB) antigen, and heat-shock proteins. J Clin Immunol 1992;12:259-65.
19. Li X, Li X, Qian L, Wang G, Zhang H, Wang X, et al. T regulatory cells are markedly diminished in diseased salivary glands of patients with primary Sjögren's syndrome. J Rheumatol 2007;34:2438-45.
20. Van Eden W, van der Zee R, Prakken B. Heat-shock proteins induce T-cell regulation of chronic inflammation. Nat Rev Immunol 2005;5:318-30.
21. Cha S, Peck AB, Humphreys-Beher MG. Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update. Crit Rev Oral Biol Med 2002;13:5-16.
22. Jonsson MV, Delaleu N, Jonsson R. Animal models of Sjögren's syndrome. Clin Rev Allergy Immunol 2007;32:215-24.
23. Delaleu N, Immervoll H, Cornelius J, Jonsson R. Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations. Arthritis Res Ther 2008;10:R22.
24. Jonsson MV, Delaleu N, Brokstad KA, Berggreen E, Skarstein K. Impaired salivary gland function in NOD mice: association with changes in cytokine profile but not with histopathologic changes in the salivary gland. Arthritis Rheum 2006;54:2300-5.
25. Cha S, Nagashima H, Brown VB, Peck AB, Humphreys-Beher MG. Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren's syndrome) on a healthy murine background. Arthritis Rheum 2002;46:1390-8.
26. Birk OS, Douek DC, Elias D, Takacs K, Dewchand H, Gur SL, et al. A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model. Proc Natl Acad Sci U S A 1996;93:1032-7.
27. Gao B, Tsan MF. Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor a from murine macrophages. J Biol Chem 2003;278:22523-9.
28. Leiter EH. The NOD mouse: a model for insulin-dependent diabetes mellitus In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W, editors. Current protocols in immunology. New York: John Wiley & Sons; 1997. p. 15.9.1-15.9.23.
29. Cha S, Brayer J, Gao J, Brown V, Killedar S, Yasunari U, et al. A dual role for interferon-γ in the pathogenesis of Sjögren's syndrome-like autoimmune exocrinopathy in the nonobese diabetic mouse. Scand J Immunol 2004;60:552-65.
30. Mantovani A, Bonecchi R, Locati M. Tuning inflammation and immunity by chemokine sequestration: decoys and more. Nat Rev Immunol 2006;6:907-18.
31. Macht LM, Elson CJ, Kirwan JR, Gaston JS, Lamont AG, Thompson JM, et al. Relationship between disease severity and responses by blood mononuclear cells from patients with rheumatoid arthritis to human heat-shock protein 60. Immunology 2000;99:208-14.
32. Massa M, Passalia M, Manzoni SM, Campanelli R, Ciardelli L, Yung GP, et al. Differential recognition of heat-shock protein dnaJ-derived epitopes by effector and Treg cells leads to modulation of inflammation in juvenile idiopathic arthritis. Arthritis Rheum 2007;56:1648-57.
33. Saito I, Haruta K, Shimuta M, Inoue H, Sakurai H, Yamada K, et al. Fas ligand-mediated exocrinopathy resembling Sjögren's syndrome in mice transgenic for IL-10. J Immunol 1999;162:2488-94.
34. + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med 2005;201:723-35.
35. De Rosa V, Procaccini C, Cali G, Pirozzi G, Fontana S, Zappacosta S, et al. A key role of leptin in the control of regulatory T cell proliferation. Immunity 2007;26:241-55.
36. H2 hypothesis of T cell-mediated tissue damage [published erratum appears in Nat Med 2007;13:385] Nat Med 2007;13:139-45.
37. Gao J, Killedar S, Cornelius JG, Nguyen C, Cha S, Peck AB. Sjögren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease. J Autoimmun 2006;26:90-103.
38. Baudino L, Azeredo da Silveira S, Nakata M, Izui S. Molecular and cellular basis for pathogenicity of autoantibodies: lessons from murine monoclonal autoantibodies. Springer Semin Immunopathol 2006;28:175-84.
39. Jin L, Zhu A, Wang Y, Chen Q, Xiong Q, Li J, et al. A Th1-recognized peptide P277, when tandemly repeated, enhances a Th2 immune response toward effective vaccines against autoimmune diabetes in nonobese diabetic mice. J Immunol 2008;180:58-63.
40. Hu S, Wang J, Meijer J, Ieong S, Xie Y, Yu T, et al. Salivary proteomic and genomic biomarkers for primary Sjögren's syndrome. Arthritis Rheum 2007;56:3588-600.
41. Balboni I, Chan SM, Kattah M, Tenenbaum JD, Butte AJ, Utz PJ. Multiplexed protein array platforms for analysis of autoimmune diseases. Annu Rev Immunol 2006;24:391-418.
42. Veenstra TD. Global and targeted quantitative proteomics for biomarker discovery. J Chromatogr B Analyt Technol Biomed Life Sci 2007;847:3-11.
43. Minamino K, Adachi Y, Okigaki M, Ito H, Togawa Y, Fujita K, et al. Macrophage colony-stimulating factor (M-CSF), as well as granulocyte colony-stimulating factor (G-CSF), accelerates neovascularization. Stem Cells 2005;23:347-54.
44. Bodolay E, Koch AE, Kim J, Szegedi G, Szekanecz Z. Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases. J Cell Mol Med 2002;6:357-76.
45. Szekanecz Z, Gaspar L, Koch AE. Angiogenesis in rheumatoid arthritis. Front Biosci 2005;10:1739-53.
46. Van Amelsfort JM, van Roon JA, Noordegraaf M, Jacobs KM, Bijlsma JW, Lafeber FP, et al. Proinflammatory mediator-induced reversal of CD4+,CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis. Arthritis Rheum 2007;56:732-42.
47. + T cells. Blood 2001;97:2758-63.
48. Cohen-Sfady M, Nussbaum G, Pevsner-Fischer M, Mor F, Carmi P, Zanin-Zhorov A, et al. Heat shock protein 60 activates B cells via the TLR4-MyD88 pathway. J Immunol 2005;175:3594-602.
49. Prochazka M, Gaskins HR, Shultz LD, Leiter EH. The nonobese diabetic seid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. Proc Natl Acad Sci U S A 1992;89:3290-4.