Interleukin-11 induces Th2 polarization of human CD4+ T cells

Blood

Volumn 97, Issue 9, 2001, Pages 2758-2763

  Curti, Antonio ^a,b,c,d   Ratta, Marina ^a,b,c,d   Corinti, Silvia ^a,b,c,d   Girolomoni, Giampiero ^a,b,c,d   Ricci, Francesca ^a,b,c,d   Tazzari, Pierluigi ^a,b,c,d   Siena, Michela ^a,b,c,d   Grande, Alexis ^a,b,c,d   Fogli, Miriam ^a,b,c,d   Tura, Sante ^a,b,c,d   Lemoli, Roberta M ^a,b,c,d,e  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^e Inst Hematol/Med Oncol Seragnoli   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD19 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; GROWTH FACTOR; INTERLEUKIN 11; INTERLEUKIN 11 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 5;

ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG SCREENING; HUMAN; HUMAN CELL; IMMUNOMODULATION; NORMAL HUMAN; POLARIZATION; PRIORITY JOURNAL; T LYMPHOCYTE; TH2 CELL;

EID: 0035353159     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.9.2758     Document Type: Article

References (22)

1. Schwertschlag US, Trepicchio WL, Dykstra KH, Keith JC, Turner KJ, Dorner AJ. Hematopoietic, immunomodulatory and epithelial effects of interleukin-11. Leukemia. 1999;13:1307-1315.
2. - cells and synergizes with stem cell factor, interleukin-3, and granulocyte-macrophage colony-stimulating factor. Exp Hematol. 1993;21:1668-1672.
3. Trepicchio WL, Wang LL, Bozza M, Dorner AJ. IL-11 regulates macrophage effector function through the inhibition of nuclear factor-kb. J Immunol. 1997;159:5661-5670.
4. Trepicchio WL, Bozza M, Pedneault G, Dorner AJ. Recombinant human IL-11 attenuates the inflammatory response through downregulation of proinflammatory cytokines release and nitric oxide production. J Immunol. 1996;157:3627-3634.
5. Redlich CA, Gao X, Rockwell S, Kelley M, Elias JA. IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury. J Immunol. 1996;157:1705-1710.
6. Leng SX, Elias JA. Interleukin-11 inhibits macrophage interleukin-12 production. J Immunol. 1997;159:2161-2168.
7. Peterson RL, Wang L, Albert L, Keith JC, Dorner AJ. Molecular effects of recombinant human interleukin-11 in the HLA-B27 rat model of inflammatory bowel disease. Lab Invest. 1998;78:1503- 1512.
8. Barton BE, Shortall J, Jackson IV. Interleukin 6 and 11 protect mice from mortality in a staphylococcal enterotoxin-induced toxic shock model. Infect Immunol. 1996;64:714-718.
9. Opal SM, Jhung JC, Palardy JE, et al. Recombinant human interleukin-11 in experimental pseudomonas aeruginosa sepsis in immunocompromised animals. J Infect Dis. 1998;178:1205-1208.
10. Hill GR, Cooke KR, Teshima T, et al. Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation. J Clin Invest. 1998;102:115-123.
11. Teshima T, Hill GR, Pan L, et al. IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation. J Clin Invest. 1999;104:317-325.
12. Trepicchio WL, Ozawa M, Walters IB, et al. Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions. J Clin Invest. 1999;104:1527-1537.
13. Schoenberger SP, Toes REM, van der Voort EIH, Offringa R, Melief CJM. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature. 1998;394:480-483.
14. + monocytes in multiple myeloma patients. Exp Hematol. 2000;28:931-940.
15. + cells. Br J Haematol. 1998;101:756-765.
16. Lemoli RM, Fogli M, Fortuna A, et al. Interleukin-11 (IL-11) acts as a synergistic factor for the proliferation of human myeloid leukemic cells. Br J Haematol. 1995;91:319-326.
17. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature. 1996;383:787-793.
18. + T cells through IL-12 produced by Listeria-induced macrophages. Science. 1993;260:547- 549.
19. Swain SL, Weinberg AD, English M, Huston G. IL-4 directs the development of Th2-like helper effectors. J Immunol. 1990;145:3796-3806.
20. + T cells. J Exp Med. 1997;185:461-469.
21. + progenitors by tumor cells: role of interleukin 6 and macrophage colony-stimulating factor. Blood. 1998;92:4778-4791.
22. D'Andrea A, Amezaga-Aste M, Valiante NM, Ma X, Kubin M, Trinchieri G. Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med. 1993;178:1041-1048.