Involvement of a specificity proteins-binding element in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene

Breast Cancer Research

Volumn 10, Issue 2, 2008, Pages

  Hockings, Jennifer K ^a   Degner, Stephanie C ^a   Morgan, Sherif S ^a   Kemp, Michael Q ^a   Romagnolo, Donato F ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ACTIVATING TRANSCRIPTION FACTOR 2; BRCA1 PROTEIN; ESTROGEN; ESTROGEN RECEPTOR; FLAVONOID; MAP2K1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PROTEIN KINASE; SP1 KINASE; TRANSCRIPTION FACTOR AP 1;

ARTICLE; BREAST TUMOR; CHROMATIN IMMUNOPRECIPITATION; DRUG ANTAGONISM; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; MUTATION; POLYMERASE CHAIN REACTION; PROMOTER REGION; TUMOR SUPPRESSOR GENE; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 2; BRCA1 PROTEIN; BREAST NEOPLASMS; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ESTROGENS; FEMALE; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BRCA1; HUMANS; MAP KINASE KINASE 1; MUTATION; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); PROTEIN KINASES; RECEPTORS, ESTROGEN; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 48949119495     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr1987     Document Type: Article

References (56)

1. Levin E. Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol 2005, 19:1951-1959. 1249516, 15705661, 10.1210/me.2004-0390.
2. Kushner P, Agard D, Feng W, Lopez G, Schiau A, Uht R, Webb P, Greene G. Oestrogen receptor function at a classical and alternative response elements. Novartis Found Symp 2000, 230:20-26.
3. McKenna N, O'Malley B. Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 2002, 108:465-474. 10.1016/S0092-8674(02)00641-4, 11909518.
4. Ogryzko V, Schiltz R, Russanova V, Howard B, Nakatani Y. The transcription coactivators p300 and CBP are histone acetyltransferases. Cell 1996, 87:953-959. 10.1016/S0092-8674(00)82001-2, 8945521.
5. Paech K, Webb P, Kuiper G, Nilsson S, Gustafsson J, Kushner P, Scanlan T. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 1997, 277:1508-1510. 10.1126/science.277.5331.1508, 9278514.
6. Porter W, Saville B, Hoivik D, Safe S. Functional synergy between the transcription factor Sp1 and the estrogen receptor. Mol Endocrinol 1997, 11:1569-1580. 10.1210/me.11.11.1569, 9328340.
7. Saville B, Wormke M, Wang F, Nguyen T, Enmark E, Kuiper G, Gustafsson J, Safe S. Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements. J Biol Chem 2000, 275:5379-5387. 10.1074/jbc.275.8.5379, 10681512.
8. Safe S, Abdelrahim M. Sp transcription factor family and its role in cancer. Eur J Cancer 2005, 41:2438-2448. 10.1016/j.ejca.2005.08.006, 16209919.
9. Yu B, Datta P, Bagchi S. Stability of the Sp3-DNA complex is promoter-specific: Sp3 efficiently competes with Sp1 for binding to promoters containing multiple Sp-sites. Nucleic Acids Res 2003, 31:5368-5376. 203306, 12954773, 10.1093/nar/gkg706.
10. Sapetschnig A, Koch F, Rischitor G, Mennenga T, Suske G. Complexity of translationally controlled transcription factor Sp3 isoform expression. J Biol Chem 2004, 279:42095-42105. 10.1074/jbc.M404989200, 15247228.
11. Bouwman P, Philipsen S. Regulation of the activity of Sp1-related transcription factors. Mol Cell Endocrinol 2002, 195:27-38. 10.1016/S0303-7207(02)00221-6, 12354670.
12. Marin M, Karis A, Visser P, Grosveld F, Philipsen S. Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell 1997, 89:619-628. 10.1016/S0092-8674(00)80243-3, 9160753.
13. Bouwman P, Gollner H, Elsasser H, Eckhoff G, Karis A, Grosveld F, Philipsen S, Suske G. Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO J 2000, 19:655-661. 305603, 10675334, 10.1093/emboj/19.4.655.
14. Gollner H, Dani C, Phillips B, Philipsen S, Suske G. Impaired ossification in mice lacking the transcription factor Sp3. Mech Dev 2001, 106:77-83. 10.1016/S0925-4773(01)00420-8, 11472836.
15. Supp D, Witte D, Branford W, Smith E, Potter S. Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility. Dev Biol 1996, 176:284-299. 10.1006/dbio.1996.0134, 8660867.
16. Wang L, Wei D, Huang S, Peng Z, Le X, Wu TT, Yao J, Ajani J, Xie K. Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer. Clin Cancer Res 2003, 9:6371-6380.
17. Yao J, Wang L, Wei D, Gong W, Hassan M, Wu T, Mansfield P, Ajani J, Xie K. Association between expression of transcription factor Sp1 and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer. Clin Cancer Res 2004, 10:4109-4117. 10.1158/1078-0432.CCR-03-0628, 15217947.
18. Shi Q, Le X, Abbruzzese J, Peng Z, Qian C, Tang H, Xiong Q, Wang B, Li X, Xie K. Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. Cancer Res 2001, 61:4143-4154.
19. Zannetti A, Del Vecchio S, Carriero M, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli M, Salvatore M. Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma. Cancer Res 2000, 60:1546-1551.
20. Bilsland A, Stevenson K, Atkinson S, Kolch W, Keith W. Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3. Cancer Res 2006, 66:1363-1370. 10.1158/0008-5472.CAN-05-1941, 16452190.
21. Merchant J, Du M, Todisco A. Sp1 phosphprylation by Erk 2 stimulates DNA binding. Biochem Biophys Res Commun 1999, 254:454-461. 10.1006/bbrc.1998.9964, 9918860.
22. Wang Y, Cortez D, Yazdi P, Neff N, Elledge S, Qin J. BASC, a super complex of BRCA-1 associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev 2000, 14:927-939. 316544, 10783165.
23. Moynahan M, Chiu J, Koller B, Jasin M. Brca1 controls homology-directed DNA repair. Mol Cell 1999, 4:511-518. 10.1016/S1097-2765(00)80202-6, 10549283.
24. Tibbetts R, Cortez D, Brumbaugh K. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev 2000, 14:2989-3002. 317107, 11114888, 10.1101/gad.851000.
25. Taylor J, Lymboura M, Pace P, A'hern R, Desai A, Shousha S, Coombes R, Ali S. An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers. Int J Cancer 1998, 79:334-342. 10.1002/(SICI)1097-0215(19980821)79:4<334::AID-IJC5>3.0.CO;2-W, 9699523.
26. Wilson CA, Ramos L, Villaseñor MR, Anders KH, Press MF, Clarke K, Karlan B, Chen JJ, Scully R, Livingston D, Zuch RH, Kanter MH, Cohen S, Calzone FJ, Slamon DJ. Localization of human BRCA1 and its loss in high grade, non-inherited breast carcinomas. Nat Genet 1999, 21:236-240. 10.1038/6029, 9988281.
27. Gudas J, Nguyen H, Li T, Cowan K. Hormone-dependent regulation of BRCA1 in human breast cancer cells. Cancer Res 1995, 55:4561-4565.
28. Gudas J, Li T, Nguyen H, Jensen D, Rauscher F, Cowan K. Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells. Cell Growth Differ 1996, 7:717-723.
29. Romagnolo D, Annab L, Thompson T, Risinger J, Terry L, Barrett J, Afshari C. Estrogen upregulation of BRCA1 expression with no effect on localization. Mol Carcinog 1998, 22:102-109. 10.1002/(SICI)1098-2744(199806)22:2<102::AID-MC5>3.0.CO;2-O, 9655254.
30. Xu C, Brown M, Chambers J, Griffiths B, Nicolai H, Solomon E. Distinct transcription start sites generate two forms of BRCA1 mRNA. Hum Mol Genet 1995, 4:2259-2264. 10.1093/hmg/4.12.2259, 8634696.
31. Fan S, Wang JA, Yuan RQ, Ma YX, Meng Q, Erdos MR, Brody LC, Goldberg ID, Rosen EM. BRCA1 inhibition of estrogen receptor signaling in transfected cells. Science 1999, 284:1354-1386. 10.1126/science.284.5418.1354, 10334989.
32. Welcsh PL, Lee MK, Gonzalez-Hernandez RM, Black DJ, Mahadevappa M, Swisher EM, Warrington JA, King MC. BRCA1 transcriptionally regulates genes involved in breast tumorigenesis. Proc Natl Acad Sci USA 2002, 99:7560-7565. 124283, 12032322, 10.1073/pnas.062181799.
33. Jeffy B, Hockings J, Kemp M, Morgan S, Hager J, Beliakoff J, Whitesell L, Bowden T, Romagnolo D. An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription. Neoplasia 2005, 7:873-882. 1501940, 16229810, 10.1593/neo.05256.
34. Hockings J, Thorne P, Kemp M, Morgan S, Selmin O, Romagnolo D. The ligand status of the aromatic hydrocarbon receptor modulates transcriptional activation of the BRCA-1 promoter by estrogen. Cancer Res 2006, 66:2224-2232. 10.1158/0008-5472.CAN-05-1619, 16489025.
35. Jeffy B, Chirnomas R, Chen E, Gudas J, Romagnolo D. Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: requirements for metabolism of benzo[a]pyrene to BPDE. Cancer Res 2002, 62:113-121.
36. Degner S, Kemp M, Bowden T, Romagnolo D. Conjugated linoleic acid attenuates cyclooxygenase-2 transcriptional activity via an anti-AP-1 mechanism in MCF-7 breast cancer cells. J Nutr 2006, 136:421-427.
37. Selmin O, Thorne PA, Blachere FM, Johnson PD, Romagnolo DF. Transcriptional activation of the membrane-bound progesterone receptor (mPR) by dioxin, in endocrine-responsive tissues. Mol Reprod Dev 2005, 70:166-174. 10.1002/mrd.20090, 15570619.
38. Sapetschnig A, Koch F, Rischitor G, Mennenga T, Suske G. Complexity of translationally controlled transcription factor Sp3 isoform expression. J Biol Chem 2004, 279:42095-42105. 10.1074/jbc.M404989200, 15247228.
39. He S, Sun J-M, Li L, Davie JR. Differential intranuclear organization of transcription factors Sp1 and Sp3. Mol Biol Cell 2005, 16:4073-4083. 1196320, 15987735, 10.1091/mbc.E05-05-0388.
40. Khan S, Wu F, Liu S, Wu Q, Safe S. Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells. J Mol Endocrinol 2007, 39:289-304. 10.1677/JME-07-0043, 17909268.
41. Collins P, Webb C. Estrogen hits the surface. Nat Med 1999, 5:1130-1131. 10.1038/13453, 10502813.
42. Higgins KJ, Liu S, Abdelrahim M, Yoon K, Vanderlaag K, Porter W, Metz RP, Safe S. Vascular endothelial growth factor receptor-2 expression is induced by 17β-estradiol in ZR-75 breast cancer cells by estrogen receptor α/Sp proteins. Endocrinology 2006, 147:3285-3295. 10.1210/en.2006-0081, 16574784.
43. Abdelrahim M, Baker CH, Abbruzzese JL, Sheikh-Hamad D, Liu S, Cho SD, Yoon K, Safe S. Regulation of vascular endolethial growth factor receptor-1 expression by specific proteins 1, 3, and 4 in pancreatic cancer cells. Cancer Res 67:3286-3294. 10.1158/0008-5472.CAN-06-3831, 17409437.
44. Itoh Y, Hayashi H, Miyazawa K, Kojima S, Akahoshi T, Onozaki K. 17beta-estradiol induces Il1α gene expression in rheumatoid fibroblast-like synovial cells through estrogen receptorα (ERα) and augmentation of transcriptional activity of Sp1 by dissociating histone acetylase 2 from ERα. J Immunol 2007, 178:3059-3066.
45. Maor S, Mayer D, Yarden RI, Lee AV, Sarfstein R, Werner H, Papa MZ. Estrogen receptor regulates insulin-like growth factor-1 receptor gene expression in breast tumor cells: involvement of transcription factor Sp1. J Endocrinol 2006, 191:605-612. 10.1677/joe.1.07016, 17170218.
46. Ru LW, Chen CC, Safe S. 17beta estradiol (E2) induces cdc25A gene expression in breast cancer cells by genomic and non-genomic pathways. J Cell Biochem 2006, 99:209-220. 10.1002/jcb.20902, 16598773.
47. Khan S, Abdelrahim M, Samudio I, Safe S. Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast cancer cells. Endocrinology 2003, 144:2325-2335. 10.1210/en.2002-0149, 12746293.
48. Duan R, Porter W, Safe S. Estrogen-induced c-fos protooncogene expression in MCF-7 human breast cancer cells: role of estrogen receptor Sp1 complex formation. Endocrinology 1998, 139:1981-1990. 10.1210/en.139.4.1981, 9528985.
49. Tang S, Bhatia B, Zhou J, Maldonado C, Chandra D, Kim E, Fischer S, Butler A, Friedman S, Tang D. Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells. Oncogene 2004, 23:6942-6953. 10.1038/sj.onc.1207913, 15247906.
50. Hasleton M, Ibbitt J, Hurst H. Characterization of the human activator protein-2gamma (AP-2gamma) gene: control of expression by Sp1/Sp3 in breast tumour cells. Biochem J 2003, 373:925-932. 1223543, 12733991, 10.1042/BJ20030388.
51. Ammanamanchi S, Brattain M. Sp3 is a transcriptional repressor of transforming growth factor-beta receptors. J Biol Chem 2001, 276:3348-3352. 10.1074/jbc.M002462200, 11027677.
52. De Siervi A, Marinissen M, Diggs J, Wang X, Pages G, Senderowicz A. Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1. Cancer Res 2004, 64:743-750. 10.1158/0008-5472.CAN-03-2505, 14744793.
53. Hagen G, Muller S, Beato M, Suske G. Sp1-mediated transcriptional activation is repressed by Sp3. EMBO J 1994, 13:3843-3851. 395297, 8070411.
54. Wang W, Dong L, Saville B, Safe S. Transcriptional activation of E2F1 gene expression by 17b-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions. Mol Endocrinol 1999, 13:1373-1387. 10.1210/me.13.8.1373, 10446910.
55. Harrington W, Kim S, Funk C, Madak-Erdogan Z, Schiff R, Katzenellenbogen J, Katzenellenbogen B. Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action. Mol Endocrinol 2006, 20:491-502. 10.1210/me.2005-0186, 16306086.
56. TRANSFAC/Match transcription factor database. , http://www.gene-regulation.com