Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: Requirements for metabolism of benzo[a]pyrene to 7r, 8t-dihydroxy-9t, 10-epoxy-7, 8, 9, 10 tetrahydrobenzo[a]pyrene

Cancer Research

Volumn 62, Issue 1, 2002, Pages 113-121

  Jeffy, Brandon D ^a   Romagnolo, Donato F ^a,a   Chirnomas, Ryan B ^a   Chen, Eddy J ^b   Gudas, Jean M ^b  

^a UNIVERSITY OF ARIZONA   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; BENZO[A]PYRENE DERIVATIVE; BRCA1 PROTEIN; CYTOCHROME P450 1A1; MESSENGER RNA; PROTEIN BAX; PROTEIN P21; PROTEIN P53;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL CULTURE; EXON; GENE EXPRESSION; GENE INDUCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MUTATION; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR UPREGULATION; TRANSCRIPTION REGULATION;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; BENZO(A)PYRENE; BIOTRANSFORMATION; BRCA1 PROTEIN; BREAST NEOPLASMS; CARCINOGENS; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BRCA1; HUMANS; PROMOTER REGIONS (GENETICS); RECEPTORS, ARYL HYDROCARBON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TETRACHLORODIBENZODIOXIN; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036141430     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. BRCA1 and BRCA2 mutations in breast cancer families with multiple primary cancers
2. Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer
3. Sequence analysis of BRCA1 and BRCA2: Correlation of mutations with family history and ovarian cancer risk
4. Somatic mutations in the BRCA1 gene in sporadic ovarian tumours
5. BRCA-1 mutations in primary breast and ovarian carcinomas
6. Methylation of the BRCA1 gene in sporadic breast cancer
7. Regulation of BRCA-1 and BRCA-2 expression in human breast cancer cells by DNA-damaging agents
8. Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer
9. Regional methylation of the 5′ end CpG island of BRCA1 is associated with reduced gene expression in human somatic cells
10. Mutations and homologous recombination induced in mammalian cells by metabolites of benzo[a]pyrene and 1-nitropyrene
11. Contrasting incidence of ras mutations in rat mammary and mouse skin tumors induced by anti-benzo[c] phenanthrene-3, 4-diol-1, 2-epoxide
12. Production of oxidative DNA damage during the metabolic activation of benzo[a]pyrene in human mammary epithelial cells correlates with cell killing
13. Physical interactions of isomeric benzo[a]pyrene diol-epoxides with DNA
14. DNA adduct formation by polycyclic aromatic hydrocarbon dihydrodiol epoxides
15. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in p53
16. Benzo[a]pyrene metabolites: Formation in rat liver cell-culture lines, binding to macromolecules, and mutagenesis in V79 hamster cells
17. 2-dG adduct of (+)-anti-B[a]PDE shows a dramatically different mutagenic specificity (predominantly, G→A) in a 5′-CGT-3′ sequence context
18. DNA reactions, mutagenic action and stealth properties of polycyclic aromatic hydrocarbon carcinogens
19. Estrogen upregulation of expression of BRCA-1 with no effect on localization
20. Hormone-dependent regulation of BRCA-1 in human breast cancer cells
21. BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogen
22. Inhibition of BRCA-1 expression by benzo[a]pyrene and its diol epoxide
23. 2
24. Cellular responses to oxidative stress: The Ah gene battery as a paradigm
25. The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons
26. p53-dependent global genomic repair of benzo[a]pyrene-7, 8-diol-9, 10-epoxide adducts in human cells
27. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
28. Benzo[a]pyrene: DNA adduct formation in normal human mammary epithelial cell cultures and the human mammary carcinoma T47D cell line
29. NAD(P)H:quinone oxidoreductase I deficiency increases susceptibility to benzo[a]pyrene-induced mouse skin carcinogenesis
30. Tumor initiating and promoting activities of various benzo[a]pyrene metabolites in mouse skin
31. Environmental factors as regulators and effectors of multistep carcinogenesis
32. BRCA-1, BRCA-2 and DNA damage response: Collision or collusion
33. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression
34. The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: Perspective, prospects, and problems
35. Human lung cancer and p53: The interplay between mutagenesis and selection
36. wafl/cipl
37. Metabolism of benzo[aJpyrene in primary cultures of human hepatocytes: Dose-response over a four-log range
38. Cell cycle control, checkpoint mechanisms, and genotoxic stress
39. Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression
40. Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2, 3, 7, 8 tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells
41. Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists
42. Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells
43. Is CYP1A1 induction always related to AHR signaling pathway?
44. Carbaryl induces CYP1A1 gene expression in HepG2 and HaCaT cells but is not a ligand of the human hepatic Ah receptor
45. Benzo[a]pyrene metabolism, activation and carcinogenesis: Role and regulation of mixed-function oxidases and related enzymes
46. DNA adduct levels associated with p53 induction and delay of MCF-7 cells in S-phase after exposure to benzo[g]chrysene dihydrodiol epoxide enantiomers
47. Inhibition of poly(ADP-ribose) polymerase increases (±)-anti-benzo[alpyrene diol-epoxide-induced micronuclei formation and p53 accumulation in isolated human peripheral blood lymphocytes
48. Modulation of (±)-anti-BPDE mediated p53 accumulation by inhibitors of protein kinase C and poly(ADP-ribose) polymerase
49. One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element
50. Oncogenic mutations of the p53 tumor suppressor: The demons of the guardian of the genome
51. Repression of BRCA-1 through a feedback loop involving p53
52. Tumor suppressor p53 is required to modulate BRCA1 expression
53. BRCA-1 regulates p53-dependent gene expression
54. The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein
55. Transactivational and DNA binding abilities of endogenous p53 in p53 mutant cell lines
56. BRCA-1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner
57. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
58. p53 function and dysfunction
59. p53 mutations increase resistance to ionizing radiation
60. p53, the cellular gatekeeper for growth and division
61. Benzo[a]pyrene-resistant MCF-7 human breast cancer cells. A unique aryl hydrocarbon-nonresponsive clone
62. Cancer susceptibility genes: Gatekeepers and caretakers