The Use of Vasopressors and Inotropes in the Emergency Medical Treatment of Shock

Emergency Medicine Clinics of North America

Volumn 26, Issue 3, 2008, Pages 759-786

  Ellender, Timothy J ^a,b   Skinner, Joseph C ^a,b  

^a INDIANA UNIVERSITY   (United States)

^b INDIANA UNIVERSITY HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ADRENERGIC RECEPTOR STIMULATING AGENT; AMRINONE; ANTIHISTAMINIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRONCHODILATING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHLORIDE; DOBUTAMINE; DOPAMINE; EPHEDRINE; GLUCAGON; GLUCONATE CALCIUM; HYPERTENSIVE FACTOR; INOTROPIC AGENT; INSULIN; ISOPRENALINE; MILRINONE; NORADRENALIN; PHENYLEPHRINE; STEROID; TRICYCLIC ANTIDEPRESSANT AGENT; VASODILATOR AGENT; VASOPRESSIN;

ANAPHYLACTIC SHOCK; CARDIOGENIC SHOCK; CRITICALLY ILL PATIENT; DRUG MEGADOSE; DRUG OVERDOSE; EMERGENCY MEDICINE; EMERGENCY TREATMENT; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REPEATED DRUG DOSE; REVIEW; SHOCK;

EID: 48949119080     PISSN: 07338627     EISSN: 07338627     Source Type: Journal    
DOI: 10.1016/j.emc.2008.04.001     Document Type: Review

References (174)

1. Mitchell R.N. Shock. In: Kumar V. (Ed). Robins and Cotran: pathologic basis of disease. 6th edition (2005), Saunders, Philadelphia 134-138
2. Lambe S., Washington D.L., Fink A., et al. Trends in the use and capacity of California's emergency departments, 1990-1999. Ann Emerg Med 39 (2002) 389
3. McCaig L.F., and Burt C.W. National hospital ambulatory medical care survey: 2002 emergency department summary. Adv Data (2004) 1
4. Jones A.E., and Kline J.A. Shock. In: Marx J. (Ed). Rosen's emergency medicine: concepts and clinical practice. 6th edition vol. 1 (2006), Mosby, Philadelphia 230-242
5. Shoemaker W.C., Peitzman A.B., Bellamy R., et al. Resuscitation from severe hemorrhage. Crit Care Med 24 (1996) S12
6. Hochman J.S., Boland J., Sleeper L.A., et al. Current spectrum of cardiogenic shock and effect of early revascularization on mortality. Results of an International Registry. SHOCK Registry Investigators. Circulation 91 (1995) 873-881
7. Shoemaker W.C. Temporal physiologic patterns of shock and circulatory dysfunction based on early descriptions by invasive and noninvasive monitoring. New Horiz 4 (1996) 300
8. Angus D.C., Linde-Zwirble W.T., Lidicker J., et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29 (2001) 1303
9. Dellinger R.P. Cardiovascular management of septic shock. Crit Care Med 31 (2003) 946
10. Osborn T.M., Tracy J.K., Dunne J.R., et al. Epidemiology of sepsis in patients with traumatic injury. Crit Care Med 32 (2004) 2234
11. Prasad A., Lennon R.J., Rihal C.S., et al. Outcomes of elderly patients with cardiogenic shock treated with early percutaneous revascularization. Am Heart J 147 (2004) 1066
12. Holmes C.L. Vasoactive drugs in the intensive care unit. Curr Opin Crit Care 11 (2005) 413-417
13. Kellum J.A., and Pinsky M.R. Use of vasopressor agents in critically ill patients. Curr Opin Crit Care 8 (2002) 236-241
14. Otero R.M., Nguyen H.B., Huang D.T., et al. Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings. Chest 130 (2006) 1579
15. Parrilo J.E. Approach to the patient with shock. In: Goldman L., and Ausiello D.A. (Eds). Cecil textbook of medicine. 22nd edition (2004), W.B. Saunders Company, Philadelphia 609
16. Rivers E.P., Ander D.S., and Powell D. Central venous oxygen saturation monitoring in the critically ill patient. Curr Opin Crit Care 7 (2001) 204
17. Barber A.E. Cell damage after shock. New Horiz 4 (1996) 161
18. Abou-Khalil B., Scalea T.M., Trooskin S.Z., et al. Hemodynamic responses to shock in young trauma patients: need for invasive monitoring. Crit Care Med 22 (1994) 633
19. Abramson D., Scalea T.M., Hitchcock R., et al. Lactate clearance and survival following injury. J Trauma 35 (1993) 584
20. Blow O., Magliore L., Claridge J.A., et al. The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma. J Trauma 47 (1999) 964
21. Scalea T.M., Maltz S., Yelon J., et al. Resuscitation of multiple trauma and head injury: role of crystalloid fluids and inotropes. Crit Care Med 22 (1994) 1610
22. Ander D.S., Jaggi M., Rivers E., et al. Undetected cardiogenic shock in patients with congestive heart failure presenting to the emergency department. [In Process Citation]. Am J Cardiol 82 (1998) 888
23. Jaggi M., McGeorge F.T., Charash D.S., et al. Occult cardiogenic shock in end-stage heart failure patients presenting to the emergency department. Clin Intensive Care 6 2 (1995) 104
24. Rady M., Jafry S., Rivers E., et al. Characterization of systemic oxygen transport in end-stage chronic congestive heart failure. Am Heart J 128 (1994) 774
25. Rady M.Y., Edwards J.D., Rivers E.P., et al. Measurement of oxygen consumption after uncomplicated acute myocardial infarction. Chest 104 (1993) 930
26. Donnino M., Nguyen B., and Rivers E.P. Severe sepsis and septic shock: a hemodynamic comparison of early and late phase sepsis. Chest 122 (2002) 5S
27. Donnino M.W., Nguyen H.B., Jacobsen G., et al. Cryptic septic shock: a sub-analysis of early goal-directed therapy. Chest 124 (2003) 90S
28. Nguyen H.B., Rivers E.P., Knoblich B.P., et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 32 (2004) 1637
29. Rivers E., Nguyen B., Havstad S., et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345 (2001) 1368
30. Knoblich B.R.E., Nguyen B., Rittinger W., et al. Lactic acid clearance (Lactime) in the emergency department: implications for the development of multisystem organ failure and death. Acad Emerg Med 6 (1999) 479
31. Rady M., and Rivers E.P. The response of blood pressure, heart rate, shock index, central venous oxygen saturataion and lactate to resuscitation in the emergency department. Crit Care Med (1995) A138
32. Rady M.Y., Rivers E.P., and Nowak R.M. Resuscitation of the critically ill in the ED: responses of blood pressure, heart rate, shock index, central venous oxygen saturation, and lactate. Am J Emerg Med 14 (1996) 218-225
33. Rodgers K.G. Cardiovascular shock. Emerg Med Clin North Am 13 (1995) 793
34. Moscucci M., and Bates E.R. Cardiogenic shock. Cardiol Clin 13 (1995) 391
35. Landry D.W., and Oliver J.A. The pathogenesis of vasodilatory shock. N Engl J Med 345 (2001) 588-595
36. Riddez L., Hahn R.G., Brismar B., et al. Central and regional hemodynamics during acute hypovolemia and volume substitution in volunteers. Crit Care Med 25 (1997) 635
37. Wo C.C., Shoemaker W.C., Appel P.L., et al. Unreliability of blood pressure and heart rate to evaluate cardiac output in emergency resuscitation and critical illness. Crit Care Med 21 (1993) 218-223
38. Rivers E. Mixed vs central venous oxygen saturation may be not numerically equal, but both are still clinically useful. Chest 129 (2006) 507
39. Trzeciak S., and Rivers E.P. Clinical manifestations of disordered microcirculatory perfusion in severe sepsis. Crit Care 9 Suppl 4 (2005) S20
40. Shoemaker W.C. Oxygen transport and oxygen metabolism in shock and critical illness: invasive and noninvasive monitoring of circulatory dysfunction and shock. Crit Care Clin 12 4 (1996) 939-969
41. Verdant C., and De Backer D. How monitoring of the microcirculation may help us at the bedside. Curr Opin Crit Care 11 3 (2005) 240-244
42. Shoemaker W.C., Kram H.B., and Appel P.L. Therapy of shock based on pathophysiology, monitoring and outcome prediction. Crit Care Med 18 (1990) S19
43. Michard F., and Teboul J.L. Predicting fluid responsiveness in ICU patients: a critical analysis of the evidence. Chest 121 (2002) 2000
44. Shoemaker W.C., Wo C.C., Yu S., et al. Invasive and noninvasive haemodynamic monitoring of acutely ill sepsis and septic shock patients in the emergency department. Eur J Emerg Med 7 (2000) 169-175
45. Pinsky M.R. Assessment of indices of preload and volume responsiveness. Curr Opin Crit Care 11 (2005) 235
46. Gunn S.R., and Pinsky M.R. Implications of arterial pressure variation in patients in the intensive care unit. Curr Opin Crit Care 7 (2001) 212
47. Magder S. Clinical usefulness of respiratory variations in arterial pressure. Am J Respir Crit Care Med 169 (2004) 151
48. Porter J.M., and Ivatury R.R. In search of the optimal end points of resuscitation in trauma patients: a review. J Trauma 44 (1998) 908
49. Hinshaw L.B. Sepsis/septic shock: participation of the microcirculation. An abbreviated review. Crit Care Med 24 6 (1996) 1072-1078
50. Hayes M.A., Timmins A.C., Yau H.S., et al. Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 330 (1994) 1717
51. Ruffolo Jr. R.R., Nichols A.J., Stadel J.M., et al. Pharmacological and therapeutic applications of alpha2-adrenoceptor subtypes. Annu Rev Pharmacol Toxicol 32 (1993) 243-279
52. Bourgoin A., Leone M., Delmas A., et al. Increasing mean arterial pressure in patients with septic shock: effects on oxygen variables and renal function. Crit Care Med 33 4 (2005) 780-786
53. LeDoux D., Astiz M.E., Carpati C.M., et al. Effects of perfusion pressure on tissue perfusion in septic shock. Crit Care Med 28 (2000) 2729-2732
54. Nagashima M., Hattori Y., Akaishi Y., et al. Alpha 1-adrenoceptor subtypes mediating inotropic and electrophysiological effects in mammalian myocardium. Am J Phys 271 (1996) H1423-H1432
55. Fedida D., and Bouchard R.A. Mechanisms for the positive inotropic effect of alpha 1-adrenoceptor stimulation in rat cardiac myocytes. Circ Res 71 (1992) 673-688
56. Grupp I.L., Lorenz J.N., Walsh R.A., et al. Over expression of alpha 1B adrenergic receptor induces left ventricular dysfunction in the absence of hypertrophy. Am J Physiol 275 (1998) H1338-H1350
57. Ishibashi Y., Duncker D.J., and Bache R.J. Endogenous nitric oxide masks alpha 2-adrenergic coronary vasoconstriction during exercise in the ischemic heart. Circ Res 80 (1997) 196-207
58. Huang L., and Tang W. Vasopressor agents: old and new components. Curr Opin Crit Care 10 (2004) 183-187
59. Steele A., and Bihari D. Choice of catecholamine: does it matter?. Curr Opin Crit Care 6 (2000) 347-353
60. Girault J., and Greengard P. The neurobiology of dopamine signaling. Arch Neurol 61 5 (2004) 641-644
61. Jose P., Eisner G., and Felder R. Regulation of blood pressure by dopamine receptors. Nephron Physiol 95 2 (2003) 19-27
62. Ricci A., Mignini F., Tomassoni D., et al. Dopamine receptor subtypes in the human pulmonary arterial tree. Auton Autacoid Pharmacol l26 4 (2006) 361-369
63. Holmes C.L., Landry D.W., and Granton J.T. Science review: vasopressin and the cardiovascular system. Part 1. Receptor physiology. Crit Care 7 6 (2003) 427-434
64. Vincent J.L. Vasopressin in hypotensive and shock states. Crit Care Clin 2 (2006) 187-197
65. Holmes C.L., Granton J.T., and Landry D.W. Science review: vasopressin and the cardiovascular system. Part 2. Clinical physiology. Crit Care 8 (2004) 15-23
66. Hollenberg S.M., Ahrens T.S., Annane D., et al. Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update. Crit Care Med 32 (2004) 1928-1948
67. Di Giantomasso D., Bellomo R., and May C.N. The haemodynamic and metabolic effects of epinephrine in experimental hyperdynamic septic shock. Intensive Care Med 31 (2005) 454-462
68. Clutter W.E., Bier D., Shah S.D., et al. Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man. J Clin Invest 66 (1980) 94-101
69. De Backer D., Creteur J., Silva E., et al. Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best?. Crit Care Med 31 (2003) 1659
70. Levy B., Bollaert P.E., Charpentier C., et al. Comparison of norepinephrine and dobutamine to epinephrine for hemodynamics, lactate metabolism, and gastric tonometric variables in septic shock: a prospective, randomized study. Intensive Care Med 23 (1997) 282-287
71. Meier-Hellmann A., Reinhart K., Bredle D.L., et al. Epinephrine impairs splanchnic perfusion in septic shock. Crit Care Med 25 (1997) 399-404
72. Duranteau J., Sitbon P., Teboul J.L., et al. Effects of epinephrine, norepinephrine, or the combination of norepinephrine and dobutamine on gastric mucosa in septic shock. Crit Care Med 27 (1999) 893-900
73. Zaritsky A.L., and Chernow B. Catecholamines, sympathomimetics. In: Chernow B., and Lake C.R. (Eds). The pharmacologic approach to the critically ill patient (1983), Williams & Wilkins, Baltimore (MD) 481-549
74. Williamson K.L., and Broadley K.J. Characterization of the alpha-adrenoreceptors mediating positive inotropy of rat left atria by use of selective agonists and antagonists. Arch Int Pharmacodyn Ther 285 (1987) 181-198
75. Gregory J.S., Bonfiglio M.F., Dasta J.F., et al. Experience with phenylephrine as a component of the pharmacologic support of septic shock. Crit Care Med 19 (1991) 1395-1400
76. Yamazaki T., Shimada Y., Taenaka N., et al. Circulatory responses to afterloading with phenylephrine in hyperdynamic sepsis. Crit Care Med 10 (1982) 432
77. Nasraway S.A. Norepinephrine: no more "leave 'em dead"?. Crit Care Med 28 (2000) 3096-3098
78. Angle M.R., Molloy D.W., Penner B., et al. The cardiopulmonary and renal hemodynamic effects of norepinephrine in canine pulmonary embolism. Chest 95 (1989) 1333-1337
79. Mathru M., Venus B., Smith R.A., et al. Treatment of low cardiac output complicating acute pulmonary hypertension in normovolemic goats. Crit Care Med 14 (1986) 120-124
80. Hirsch L.J., Rooney M.W., Wat S.S., et al. Norepinephrine and phenylephrine effects on right ventricular function in experimental canine pulmonary embolism. Chest 100 (1991) 796-801
81. Russell J.A., and Phang P.T. The oxygen delivery/consumption controversy. Am J Respir Crit Care Med 149 (1994) 533
82. Schaer G.L., Find M.P., and Parrillo J.E. Norepinephrine alone versus norepinephrine plus low-dose dopamine: enhanced renal blood flow with combination pressor therapy. Crit Care Med 13 (1985) 492
83. Redl-Wenzl E.M., Armbruster C., Edelmann G., et al. The effects of norepinephrine on hemodynamics and renal function in severe septic shock states. Intensive Care Med 19 (1993) 151
84. Desjars P., Pinaud M., Bugnon D., et al. Norepinephrine therapy has no deleterious renal effects in human septic shock. Crit Care Med 17 (1989) 426-429
85. Marik P.E., and Mohedin M. The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis. JAMA 272 (1994) 1354
86. Martin C., Papazian L., Perrin G., et al. Norepinephrine or dopamine for the treatment of hyperdynamic septic shock?. Chest 103 (1993) 1826-1831
87. Martin C., Viviand X., Leone M., et al. Effect of nor-epinephrine on the outcome of septic shock. Crit Care Med 28 (2000) 2758-2765
88. Morimatsu H., Singh K., Uchino S., et al. Early and exclusive use of norepinephrine in septic shock. Resuscitation 62 (2004) 249
89. Baele R.J., Hollenberg S.M., Vincent J.L., et al. Vasopressor and inotropic support in septic shock: an evidence based review. Crit Care Med 32 Suppl (2004) S455-S465
90. Dellinger R.P., Levy M.M., Carlet J.M., et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 36 1 (2008) 296-327
91. Goldberg L.I. Dopamine: clinical uses of an endogenous catecholamine. N Engl J Med 291 (1974) 707
92. Guerin J.P., Levraut J., Samat-Long C., et al. Effects of dopamine and norepinephrine on systemic and hepatosplanchnic hemodynamics, oxygen exchange, and energy balance in vasoplegic septic patients. Shock 23 (2005) 18-24
93. Kellum J.A., and Decker J.M. The use of dopamine in acute renal failure: a metaanalysis. Crit Care Med 29 (2001) 1526-1531
94. Holmes C.L., and Walley K.R. Bad medicine: low-dose dopamine in the ICU. Chest 123 (2003) 1266-1275
95. MacGregor D.A., Smith T.E., Prielipp R.C., et al. Pharmacokinetics of dopamine in healthy male subjects. Anesthesiology 92 (2000) 338
96. Al-Hesayen A., Azevedo E.R., Newton G.E., et al. The effects of dobutamine on cardiac sympathetic activity in patients with congestive heart failure. J Am Coll Cardiol 39 (2002) 1269
97. Landry D.W., Levin H.R., Gallant E.M., et al. Vasopressin deficiency contributes to the vasodilation of septic shock. Circulation 95 (1997) 1122-1125
98. Dunser M.W., Mayr A., Ulmer H.R., et al. The effects of vasopressin on systemic hemodynamics in catecholamine-resistant septic and postcardiotomy shock: a retrospective analysis. Anesth Analg 93 (2001) 7-13
99. Lollgen H., and Drexler H. Use of inotropes in the critical care setting. Crit Care Med 18 (1990) S56
100. Honerjager P. Pharmacology of bipyridine phosphodiesterase III inhibitors. Am Heart J 121 (1991) 1939-1944
101. Packer M., Carver J.R., Rodeheffer R.J., et al. Effect of oral milrinone on mortality in severe chronic heart failure: The PROMISE Study Research Group. N Engl J Med 325 (1991) 1468-1475
102. Milfred-LaForest S.K., Shubert J., Mendoza B., et al. Tolerability of extended duration intravenous milrinone in patients hospitalized for advanced heart failure and the usefulness of uptitration of oral angiotensin-converting enzyme inhibitors. Am J Cardiol 84 (1999) 894-899
103. Hatzizacharias A., Makris T., Krespi P., et al. Intermittent milrinone effect on long-term hemodynamic profile in patients with severe congestive heart failure. Am Heart J 138 (1999) 241-246
104. Silver M.A. Intermittent inotropes for advanced heart failure: inquiring minds want to know. Am Heart J 138 (1999) 191-192
105. Pollack C.V. Utility of glucagon in the emergency department. J Emerg Med 11 (1993) 195-205
106. Kerns W. Treatment of beta adrenergic blocker and calcium channel antagonist toxicity. Emerg Med Clin North Am 25 (2007) 309-331
107. Holger J.S., Engebretsen K.M., Obetz C.L., et al. A comparison of vasopressin and glucagon in beta-blocker induced toxicity. Clin Toxicol 44 (2006) 45-51
108. Love J.N., Sachdeva D.K., Bessman E.S., et al. A potential role for glucagon in the treatment of drug-induced symptomatic bradycardia. Chest 114 (1998) 323-326
109. Love J.N., Howell J.M., Litovitz T.L., et al. Acute beta blocker overdose: factors associated with the development of cardiovascular morbidity. J Toxicol Clin Toxicol 38 (2000) 275-281
110. Chernow B., Zaloga G.P., Malcolm D., et al. Glucagon's chronotropic action is calcium dependent. J Pharmacol Exp Ther 241 3 (1987) 833-837
111. Doyon S., and Roberts J.R. The use of glucagon in a case of calcium channel blocker overdose. Ann Emerg Med 22 7 (1993) 1229-1233
112. Mahr N.C., Valdes A., and Lamas G. Use of glucagon for acute intravenous diltiazem toxicity. Am J Cardiol 79 11 (1997) 1570-1571
113. Papadopoulos J., and O'Neil M.G. Utilization of a glucagon infusion in the management of a massive nifedipine overdose. J Emerg Med 18 (2000) 453-455
114. Sensky P.R., and Olczak S.A. High dose intravenous glucagon in severe tricyclic poisoning. Postgrad Med J 75 (1999) 611-612
115. Kline J.A., Tomaszewski C.A., Schroeder J.D., et al. Insulin is a superior antidote for cardiovascular toxicity induced by verapamil in the anesthetized canine. J Pharmacol Exp Ther 267 2 (1993) 744-750
116. Farah A.E., and Alousi A.A. The actions of insulin on cardiac contractility. Life Sci 29 (1981) 975-1000
117. Boyer E.W., Duic P.A., and Evans A. Hyperinsulinemia/euglycemia therapy for calcium channel blocker poisoning. Pediatr Emerg Care 18 (2002) 36-37
118. Boyer E.W., and Shannon M. Treatment of calcium-channel-blocker intoxication with insulin infusion. N Engl J Med 344 (2001) 1721-1722
119. Marques M., Gomes E., and de Oliviera J. Treatment of calcium channel blocker intoxication with insulin infusion: case report and literature review. Resuscitation 57 (2003) 211-213
120. Reith D.M., Dawson A.H., Epid D., et al. Relative toxicity of beta blockers in overdose. J Toxicol Clin Toxicol 34 (1996) 273-278
121. Kerns W., Schroeder D., Williams C., et al. Insulin improves survival in a canine model of acute beta-blocker toxicity. Ann Emerg Med 29 (1997) 748-757
122. Haddad L.M. Resuscitation after nifedipine overdose exclusively with intravenous calcium. Am J Emerg Med 14 (1996) 602-603
123. Pertoldi F., D'Orlando L., and Mercante W.P. Electromechanical dissociation 48 hours after atenolol overdose: usefulness of calcium chloride. Ann Emerg Med 31 (1998) 777
124. Love J., Hanfling D., and Howell J.M. Hemodynamic effects of calcium chloride in a canine model of acute propranolol intoxication. Ann Emerg Med 28 (1996) 1
125. Isbister G.K. Delayed asystolic cardiac arrest after diltiazem overdose: resuscitation with high dose intravenous calcium. Emerg Med J 19 (2002) 355
126. Lam Y.M., Tse H.F., and Lau C.P. Continuous calcium chloride infusion for massive nifedipine overdose. Chest 119 (2001) 1280
127. Mullner M., Urbanek B., Havel C., et al. Vasopressors for shock. Cochrane Database Syst Rev 2 (2008) CD003709
128. Jones A.E. What vasopressors should be used to treat shock?. Ann Emerg Med 49 3 (2007) 367-368
129. Sampson H.A., Munoz-Furlong A., Bock S.A., et al. Symposium on the definition and management of anaphylaxis: summary report. J Allergy Clin Immunol 115 (2005) 584
130. Silverman H.J., Van Hook C., and Haponik E.F. Hemodynamic changes in human anaphylaxis. Am J Med 77 2 (1984) 341-344
131. DeJarnatt A.C., and Grant J.A. Basic mechanisms of anaphylaxis and anaphylactoid reactions. Immunol Allergy Clin North Am 12 (1992) 501
132. Brown G.A. The pathophysiology of shock in anaphylaxis. Immunol Allergy Clin North Am 27 (2007) 165-175
133. Pumphrey R.S. Lessons for management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy 30 8 (2000) 1144-1150
134. Wasserman S.I. The heart in anaphylaxis. J Allergy Clin Immunol 77 (1986) 663
135. Chamberlain D. Emergency medical treatment of anaphylactic reactions. Project Team of the Resuscitation Council (UK). J Accid Emerg Med 16 (1999) 243
136. Lieberman P., Kemp S., Oppenheimer J., et al. The diagnosis and management of anaphylaxis: an updated practice parameter. J Allergy Clin Immunol 115 (2005) S483
137. Sampson H.A., Munoz-Furlong A., Campbell R.L., et al. Second symposium on the definition and management of anaphylaxis: summary report-Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium. J Allergy Clin Immunol 117 (2006) 391
138. Fisher M. Treating anaphylaxis with sympathomimetic drugs. BMJ 305 (1992) 1107-1108
139. Heytman M., and Rainbird A. Use of alpha-agonists for management of anaphylaxis occurring under anaesthesia: case studies and review. Anaesthesia 59 12 (2004) 1210-1215
140. Simons F.E., Gu X., and Simons K.J. Epinephrine absorption in adults: intramuscular versus subcutaneous injection. J Allergy Clin Immunol 108 (2001) 871
141. Raymondos K., Panning B., Leuwer M., et al. Absorption and hemodynamic effects of airway administration of adrenaline in patients with severe cardiac disease. Ann Intern Med 132 (2000) 800
142. Zaloga G.P., Delacey W., Holmboe E., et al. Glucagon reversal of hypotension in a case of anaphylactoid shock. Ann Intern Med 105 (1986) 65
143. Thomas M., and Crawford I. Best evidence topic report: glucagon infusion in refractory anaphylactic shock in patients on beta blockers. Emerg Med J 22 4 (2005) 272-273
144. Schummer W., Schummer C., Wippermann J., et al. Anaphylactic shock: is vasopressin the drug of choice?. Anesthesiology 101 4 (2004) 1025-1027
145. Tator C.H. Experimental and clinical studies of the pathophysiology and management of acute spinal cord injury. J Spinal Cord Med 19 4 (1996) 206-214
146. Tator C.H., and Fehlings M.G. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 75 (1991) 15-26
147. Levi L., Wolf A., and Belzberg H. Hemodynamic parameters in patients with acute cervical cord trauma: description, intervention, and prediction of outcome. Neurosurgery 33 6 (1993) 1007-1017
148. Isaac L., and Pejic L. Secondary mechanisms of spinal cord injury. Surg Neurol 43 (1995) 484-485
149. Vale F.L., Burns J., Jackson A.B., et al. Combined medical and surgical treatment after acute spinal cord injury: results of a prospective pilot study to assess the merits of aggressive medical resuscitation and blood pressure management. J Neurosurg 87 (1997) 239-246
150. Amar A.P., and Levy M.L. Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury. Neurosurgery 44 5 (1999) 1027-1040
151. Goldberg R.J., Gore J.M., Alpert J.S., et al. Cardiogenic shock after acute myocardial infarction. Incidence and mortality from a community wide perspective, 1975 to 1988. N Engl J Med 325 (1991) 1117
152. Goldberg R.J., Gore J.M., Thompson C.A., et al. Recent magnitude of and temporal trends (1994-1997) in the incidence and hospital death rates of cardiogenic shock complicating acute myocardial infarction: The second National Registry of Myocardial Infarction. Am Heart J 141 (2001) 65
153. Berger P.B., Holmes D.R., Stebbins A.L., et al. Impact of an aggressive invasive catheterization and revascularization strategy on mortality in patients with cardiogenic shock in the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO-I) trial. Circulation 96 (1997) 122
154. Sanborn T.A., Sleeper L.A., Bates E.R., et al. Impact of thrombolysis, intra-aortic balloon pump counterpulsation, and their combination in cardiogenic shock complicating acute myocardial infarction: a report from the SHOCK Trial Registry. Should we emergently revascularize occluded coronaries for cardiogenic shock?. J Am Coll Cardiol 36 (2000) 1123
155. Anbe D.T., Armstrong P.W., Bates E.R., et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction. Available at:. http://www.cardiosource.com/guidelines/guidelines/stemi/index.pdf Accessed December 15, 2007
156. Piazza F., and Goldhaber S.Z. The acutely decompensated right ventricle: pathways for diagnosis and management. Chest 128 (2005) 1836-1852
157. Brieke A., and DeNofrio D. Right ventricular dysfunction in chronic dilated cardiomyopathy and heart failure. Coron Artery Dis 16 (2005) 5-11
158. Cecconi M., Johnston E., and Rhodes A. What role does right side of the heart play in circulation?. Crit Care 10 Suppl 3 (2006) S5
159. Goldstien J.A. Pathophysiology and management of the right heart ischemia. J Am Coll Cardiol 40 (2002) 841-853
160. Goldhaber S.Z., and Elliott C.G. Acute pulmonary embolism. Part I. Epidemiology, pathophysiology and diagnosis. Circulation 108 (2003) 2726-2729
161. Woods J., Monteiro P., and Rhodes A. Right ventricular dysfunction. Curr Opin Crit Care 13 (2007) 532-540
162. Louie E.K., Lin S.S., Rehnertson S.I., et al. Pressure and volume loading of the right ventricle have opposite effects on left ventricular ejection fraction. Circulation 92 (1995) 819-824
163. Budev M., Arroliga A., Wiedemann H., et al. Cor pulmonale: an overview. Semin Respir Crit Care Med 24 (2003) 233-244
164. Mebazaa A., Karpati P., Renaud E., et al. Acute right ventricular failure: from pathophysiology to new treatments. Intensive Care Med 30 (2004) 185-196
165. Pfisterer M. Right ventricular involvement in myocardial infarction and cardiogenic shock. Lancet 362 (2003) 392-394
166. Mercat A., Diehl J.L., Meyer G., et al. Hemodynamic effects of fluid loading in acute massive pulmonary embolism. Crit Care Med 27 (1999) 540-544
167. Lee F.A. Hemodynamics of the right ventricle in normal and disease states. Cardiol Clin 10 (1992) 59
168. Boulain T., Lanotte R., Legras A., et al. Efficacy of epinephrine therapy in shock complicating pulmonary embolism. Chest 104 (1993) 300-302
169. Gold J., Cullinane S., Chen J., et al. Vasopressin in the treatment of milrinone-induced hypotension in sever heart failure. Am J Cardiol 85 (2000) 506-508 A511
170. Follath F., Cleland J.G., Just H., et al. Efficacy and safety of intravenous levosimendan compared with dobutamine in sever low-output heart failure (the LIDO study). Lancet 360 (2002) 196-202
171. Zairis M.N., Apostolatos C., Anastasiadis P., et al. The effect of calcium sensitizer or an inotrope or none in the chronic low output decompensated heart failure: results from the Calcium Sensitizer or Inotrope or None in Low Output Heart Failure Study (CASINO). [Abstract 835-836]. J Am Coll Cardiol 43 (2004) 206A
172. Mebazza A., Nieminen M., Packer M., et al. Levosimendan vs dobutamine for patients with acute decompensated heart failure: the SURVIVE Randomized Trial. JAMA 297 (2007) 1883-1891
173. Smith H.J., Oriol A., Morch J., et al. Hemodynamic studies in cardiogenic shock: treatment with isoproterenol and metaraminol. Circulation 35 (1967) 1084
174. Tanak J., Tajimi K., Matsumoto A., et al. Vaso dilatory effects of milrinone on pulmonary vasculature in dogs with pulmonary hypertension due to pulmonary embolism: a comparison with those of dopamine and dobutamine. Clin Exp Pharmocol Physiol 17 (1990) 681