Effects of dopamine and norepinephrine on systemic and hepatosplanchnic hemodynamics, oxygen exchange, and energy balance in vasoplegic septic patients

Shock

Volumn 23, Issue 1, 2005, Pages 18-24

  Guérin, Jean Philippe ^a   Levraut, Jacques ^a   Samat Long, Corine ^a   Leverve, Xavier ^b   Grimaud, Dominique ^a   Ichai, Carole ^a,c  

^a UNIVERSITY HOSPITAL OF NICE   (France)

^b UNIV GRENOBLE ALPES   (France)

^c University Hospital of Nice University of Nice Sophia Antipolis   (France)

Author keywords

Cardiac output; Dopamine; Energy balance; Norepinephrine; Oxygen consumption; Sepsis; Splanchnic blood flow

Indexed keywords

ANTIARRHYTHMIC AGENT; DOPAMINE; INDOCYANINE GREEN; LACTIC ACID; NORADRENALIN; PYRUVIC ACID;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG EFFECT; DRUG EFFICACY; ENERGY BALANCE; FEMALE; HEART INDEX; HEART OUTPUT; HEART SUPRAVENTRICULAR ARRHYTHMIA; HEMODYNAMICS; HUMAN; LIVER BLOOD FLOW; MALE; MEAN ARTERIAL PRESSURE; OXYGEN CONSUMPTION; OXYGENATION; RANDOMIZED CONTROLLED TRIAL; SEPSIS; SPLANCHNIC BLOOD FLOW; VASCULAR DISEASE; VASOPLEGIA;

ADULT; ARTERIES; BLOOD PRESSURE; DOPAMINE; ENERGY METABOLISM; FEMALE; HEART RATE; HEMODYNAMIC PROCESSES; HUMANS; INDOCYANINE GREEN; LIVER; MALE; MIDDLE AGED; NOREPINEPHRINE; OXYGEN; OXYGEN CONSUMPTION; PERFUSION; PRESSURE; SEPSIS; SPLANCHNIC CIRCULATION; TIME FACTORS;

EID: 11444259304     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000150549.45338.6c     Document Type: Article

References (43)

1. Carrico CJ, Meakins JL, Marshall JC, Freg D, Maier RV: Multiple organ failure. Arch Surg 121:196-208, 1986.
2. Parrillo JE: Septic shock in humans: advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann Intern Med 113:227-242, 1990.
3. Ruokonen E, Takala J, Kari A, Saxen H, Mertsola J, Hansen EJ: Regional blood flow and oxygen transport in septic shock. Crit Care Med 21:1296-1303, 1993.
4. Maynard ND, Bihari DJ, Dalton RN, Smithies MN, Mason RC: Increasing splanchnic blood flow in the critically ill. Chest 108:1648-1654, 1995.
5. 2 exchange and energy balance. Am J Respir Crit Care Med 159:1758-1765, 1999.
6. Preiser JC, Sun Q, Hadj-Sadok D, Vincent JL: Differential effects of a selective inhibitor of soluble guanylyl cyclase on global and regional hemodynamics during canine endotoxic shock. Shock 5:465-468, 2003.
7. Dahn MS, Lange P, Lobdell K, Hans B, Jacobs LA, Mitchell RA: Splanchnic and total body oxygen consumption differences in septic and injured patients. Surgery 101:69-80, 1987.
8. Murphey ED, Traber DL: Cardiopulmonary and splanchnic blood flow during 48 hours of a continuous infusion of endotoxin in conscious pigs: a model of hyperdynmic shock. Shock 13:224-229, 2000.
9. Reinelt H, Radermacher P, Fischer G, Geisser W, Wachter U, Wiedeck H, Georgieff M, Vogt J: Effects of dobutamine-induced increase in splanchnic blood flow on hepatic metabolism activity in patients with septic shock. Anesthesiology 86:818-824, 1997.
10. Martin C, Papazian L, Perrin G, Saux P, Gouin F: Norepinephrine or dopamine for the treatment of hyperdynamic septic shock. Chest 103:1826-1831, 1993.
11. DeBacker D, Creteur J, Silva E, Vincent JL: Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best? Crit Care Med 31:1659-1667, 2003.
12. Desjars P, Pinaud M, Brignon D, Tasseau F: Norepinephrine therapy has no deleterious renal effects in human septic shock. Crit Care Med 17:426-429, 1989.
13. Meadows D, Edwards JD, Wilkins RG, Nightingale P: Reversal of intractable septic shock with norepinephrine therapy. Crit Care Med 16:663-666, 1988.
14. Marik PE, Mohedin M: The contrasting effects or dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis. JAMA 272:1354-1357, 1994.
15. Zhang H, Smail N, Cabral A, Rogiers P, Vincent JL: Effects of norepinephrine on regional blood flow and oxygen extraction capabilities during endotoxic shock. Am J Respir Crit Care Med 155:1965-1971, 1997.
16. Lévy B, Bollaert PE, Charpentier C, Nace L, Audibert G, Bauer Ph, Nabet P, Larcan A: Comparison of norepinephrine and dobutamine to epinephrine for hemodynamics, lactate metabolism, and gastric tonometric variables in septic shock: a prospective randomized study. Intensive Care Med 23:282-287, 1997.
17. Meier-Hellmann A, Specht AM, Hannemann L, Hassel H, Bredle DL, Reinhart K: Splanchnic blood flow is greater in septic shock treated with norepinephrine than in severe sepsis. Intensive Care Med 22:1354-1359, 1996.
18. 2 and metabolism transient? Intensive Care Med 21:50-56, 1995.
19. Ruttimann Y, Schutz Y, Jéquier E, Lemarchand T, Chioléro R: Thermogenic and metabolic effects of dopamine in healthy men. Crit Care Med 19:1031-1036, 1991.
20. Kiefer P, Tugtekin I, Wiedeck H, Vogt J, Wachter U, Bracht H, Geldner G, Georgieff M, Radermacher P: Effect of dopexamine on hepatic metabolic activity in patients with septic shock. Shock 15:427-431, 2001.
21. Reinelt H, Radermacher P, Kiefer P, Fischer G, Wachter U, Vogt J, Georgieff M: Impact of exogenous β-adrenergic receptor stimulation on hepatosplanchnic oxygen kinetics and metabolic activity in septic shock. Crit Care Med 27:325-331, 1999.
22. King CJ, Tytgat S, Delude RL, Fink MP: Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine. Crit Care Med 27:2518-2525, 1999.
23. American College of Chest Physicians Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:864-874, 1992.
24. Ichai C, Levraut J, Baruch I, Samat-Long C, Leverve X, Grimaud D: Hypocapnia does not alter hepatic blood flow or oxygen consumption in patients with head injury. Crit Care Med 26:1725-1730, 1998.
25. Duranteau J, Sitbon P, Teboul JL, Vicaut E, Anguel N, Richard C, Samii K: Effects of epinephrine, norepinephrine, or the combination of norepinephrine and dobutamine on gastric mucosa in septic shock. Crit Care Med 27:893-900, 1999.
26. De Backer D, Zhang H, Cherkhaoui S, Borgers M, Vincent JL: Effects of dobutamine on hepato-splanchnic hemodynamics in an experimental model of hyperdynamic endotoxic shock. Shock 15:208-214, 2001.
27. Gilbert EM, Haupt MT, Mandanas RY, Huaringa AJ, Carlson RW: The effect of fluid loading, blood transfusion, and catecholamine infusion on oxygen delivery and consumption in patients with sepsis. Am Rev Respir Dis 134:873-878, 1986.
28. Leverve X: From tissue perfusion to metabolic marker: assessing organ competition and co-operation in critically ill patients? Intensive Care Med 25:890-892, 1999.
29. Hotchkiss RS, Karl IE: Reevaluation of the role of cellular hypoxic and bioenergetic failure in sepsis. JAMA 267:1503-1510, 1992.
30. Germann R, Haisjackl M, Schwarz B, Dursch E, Mensburger S, Gruber E, Pakj W, Hausdorfer H, Bonatti J, Furtner B, Ulmer H, Hasibeder W: Inotropic treatment and intestinal mucosal tissue oxygenation in a model of porcine endotoxemia. Crit Care Med 25:1191-1197, 1997.
31. Schiffer ER, Schwieger IM, Gostelli P, Poinsot O, Mentha G, Morel DR: Systemic and splanchnic oxygen supply-demand relationship with fenodolpam, dopamine and noradrenaline in sheep. Eur J Pharmacol 286:49-60, 1995.
32. Cheung PY, Barrington KJ, Pearson RJ, Bigam DL, Finer NN, Van Aerde JE: Systemic, pulmonary and mesenteric perfusion and oxygenation effects of dopamine and epinephrine. Am J Respir Crit Care Med 155:32-37, 1997.
33. Meier-Hellmann A, Bredle DL, Specht M, Spies CD, Hannemann L, Reinhart K: The effects of low-dose dopamine on splanchnic blood flow and oxygen uptake in patients with septic shock. Intensive Care Med 23:31-37, 1997.
34. Nevière R, Mathieu D, Chagnon JL, Lebleu N, Wattel F: The contrasting effects of dobutamine and dopamine on gastric mucosal perfusion in septic patients. Am J Respir Crit Care Med 154:1684-1688, 1996.
35. Olson O, Pohlman A, Hall JB: Administration of low-dose dopamine to non oliguric patients with sepsis syndrome does not raise intramucosal gastric pH nor improve creatinine clearance. Am J Respir Crit Care Med 154:1664-1670, 1996.
36. Takala J: Determinants of splanchnic blood flow. Br J Anaesth 77:50-58, 1995.
37. Brinkmann A, Calzia E, Träger K, Radermacher P: Monitoring the hepatosplanchnic region in the critically ill patients. Measurement techniques and clinical relevance. Intensive Care Med 24:542-556, 1998.
38. 2 gradient does not reflect systemic and splanchnic hemodynamics or oxygen transport after cardiac surgery. Shock 14:13-17, 2000.
39. Jakob SM, Ruokonen E, Rosenberg PH, Takala J: Effect of dopamine-induced changes in splanchnic blood flow on MEGX production from lidocaine in septic and cardiac surgery patients. Shock 18:1-7, 2002.
40. Levraut J, Ciebiera JP, Chave S, Grimaud D: Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med 157:1021-1026, 1998.
41. Wang P, Ayala A, Ba ZF, Zhou M, Perrin MM, Chaudry H: Tumor necrosis factor-alpha produces hepatocellular dysfunction despite normal cardiac output and hepatic microcirculation. Am J Physiol 265:G126-G132, 1993.
42. Ben-Shachar D, Zuk R, Glinka Y: Dopamine neurotoxicity: inhibition of mitochondrial respiration. J Neurochem 64:718-723, 1995.
43. Nakatani T, Isihkava Y, Kobayashi K, Ozawa K: Hepatic mitochondrial redox state in hypotensive brain-dead patients and an effect of dopamine administration. Intensive Care Med 17:103-107, 1991.