Vasopressor agents: Old and new components

Current Opinion in Critical Care

Volumn 10, Issue 3, 2004, Pages 183-187

  Huang, Lei ^a   Tang, Wanchun ^a,b  

^a INSTITUTE OF CRITICAL CARE MEDICINE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Adrenergic agent; Nonadrenergic agent; Vasopressor agent

Indexed keywords

ADRENALIN; ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANGIOTENSIN; ENDOTHELIN 1; HYPERTENSIVE AGENT; NORADRENALIN; VASOPRESSIN; VASOCONSTRICTOR AGENT;

BRAIN PERFUSION; CHRONOTROPISM; CORONARY ARTERY BLOOD FLOW; DIASTOLIC BLOOD PRESSURE; DRUG EFFICACY; DRUG SAFETY; HEART ARREST; HEMODYNAMICS; HUMAN; INOTROPISM; NONHUMAN; ORGAN PERFUSION; PRESSOR RESPONSE; RESUSCITATION; REVIEW; VASOCONSTRICTION; CLASSIFICATION; INTENSIVE CARE; METHODOLOGY;

ADRENERGIC AGENTS; CARDIOPULMONARY RESUSCITATION; CRITICAL CARE; HEART ARREST; HUMANS; VASOCONSTRICTOR AGENTS;

EID: 4644287995     PISSN: 10705295     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ccx.0000125493.84614.35     Document Type: Review

References (47)

1. Tang W, Weil MH, Sun SJ, et al.: The effects of biphasic and conventional monophasic defibrillation on postresuscitation myocardial function. J Am Coll Cardiol 1999, 34:815-822.
2. 2 as in indicator of systemic perfusion during cardiopulmonary resuscitation. Crit Care Med 1989, 17:237-240.
3. Tang W, Weil MH, Sun SJ, et al.: Epinephrine increases the severity of post-resuscitation myocardial dysfunction. Circulation 1995, 92:3089-3093. This study brought the reconsideration of the routine use of epinephrine during CPR.
4. Ditchey RV, Lindenfeld J: Failure of epinephrine to improve the balance between myocardial oxygen supply and demand during closed-chest resuscitation in dogs. Circulation 1988, 78:382-389.
5. Holmberg M, Holmgerg S, Herlitz J: Low chance of survival among patients requiring adrenaline (epinephrine) or intubation after out-of-hospital cardiac arrest in Sweden. Resuscitation 2002, 54:37-45. This prospective clinical study supported previous experimental findings and demonstrated the close correlation between administration of epinephrine and the worsened outcome of cardiac arrest.
6. Sun S, Weil MW, Tang W, et al.: Combined effects of buffer and adrenergic agents on postresuscitation myocardial function. J Pharmacol Exp Ther 1999, 291:773-777.
7. Ralston SH, Tacker WA, Showen L, et al.: Endotracheal versus intravenous epinephrine during electromechanical dissociation with CPR in dogs. Ann Emerg Med 1985, 14:1044-1048.
8. Callaham ML, Madsen CD, Barton CW, et al.: A randomized clinical trial of high-dose epinephrine and norepinephrine vs standard-dose epinephrine in prehospital cardiac arrest. JAMA 1992, 268:2667-2672.
9. Laurent I, Monchi M, Chiche JD, et al.: Reversible myocardlal dysfunction in survivors of out-of-hospital cardiac arrest. J Am Coll Cardiol 2002, 40:2110-2116. This recent study confirmed worsened outcome after high-dose epinephrine.
10. AHA Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2000, 8(suppl):I-86-I-89.
11. Angelos MG, Ward KR, Beckley PD: Norepinephrine-induced hypertension following cardiac arrest: effects on myocardial oxygen use in a swine model. Ann Emerg Med 1994, 24:907-914.
12. Lindner KH, Ahnefeld FW, Pfenninger EG, et al.: Effects of epinephrine and norepinephrine on cerebral oxygen delivery and consumption during open-chest CPR. Ann Emerg Med 1990, 19:249-254.
13. Lindner KH, Annefeld FW, Grunert A: Epinephrine versus norepinephrine in pre-hospital ventricular fibrillation. Am J Cardiol 1991, 67:427-428.
14. Zhao M, Hagler HK, Muntz KH: Regulation of alpha 1-, beta-1 and beta 2-adrenergic receptors in rat heart by norepinephrine. Am J Physiol 1996, 271:H1762-H1768.
15. Brown CG, Birinyi F, Werman HA, et al.: The comparative effects of epinephrine versus phenylephrine on regional cerebral blood flow during Cardiopulmonary resuscitation. Resuscitation 1986, 14:171-183.
16. Grupp IL, Lorenz JN, Walsh RA, et al.: Over expression of alpha 1B-adrenergic receptor induces left ventricular dysfunction in the absence of hypertrophy. Am J Physiol 1998, 275:H1338-H1350.
17. Ditchey RV, Rubio-Perez A, Slinker BK: Beta-adrenergic blockade reduces myocardial injury during experimental cardiopulmonary resuscitation. J Am Coll Cardiol 1994, 24:804-812.
18. Gregorini L, Marco J, Kozakova ME, et al.: Alpha-adrenergic blockade improves recovery of myocardial perfusion and function after coronary stenting in patients with acute myocardial infarction. Circulation 1999, 99:482-490.
19. Ishibashi Y, Duncker DJ, Bache RJ: Endogenous nitric oxide masks alpha 2-adrenergic coronary vasoconstriction during exercise in the ischemic heart. Circ Res 1997, 80:196-207.
20. Lindner KH, Haak T, Keller A, et al.: Release of endogenous vasopressor during and after cardiopulmonary resuscitation. Br Heart J 1996, 75:145-150.
21. 2-adrenergic stimulation is protective against ischemia-reperfusion-induced ventricular arrhythmias in vivo. Am J Physiol 2002, 283:H2606-H2611.
22. Kahn ZP, Ferguson CN, Jones RM: Alpha-2 and imidazoline receptor agonists: their pharmacology and therapeutic role. Anesthesia 1999, 54:146-165.
23. Ruffolo RR Jr, Nichols AJ, Stadel JM, et al.: Pharmacological and therapeutic applications of alpha2-adrenoceptor subtypes. Ann Rev Pharmacol Toxicol 1993, 32:243-279.
24. Schäfers RF, Nürnberger J, Herrmann B, et al.: Adrenoceptors mediating the cardiovascular and metabolic effects of α- methylnoradrenaline in humans. J Pharmacol Exp Ther 1999, 289:918-925.
25. 2-adrenergic agontet is a promising drug in improving postresuscitation myocardial dysfunction.
26. 2- adrenergic agonist was further proved to produce a more favorable short- and long-term outcome compared with epinephrine and vasopressin.
27. 2-adrenergic agonist for cardiac resuscitation. J Mol Cell Cardiol 2001, 37:951-956.
28. Loeckinger A, Kleinsasser A, Wenzel V, et al.: Pulmonary gas exchange after cardiopulmonary resuscitation with either vasopressin or epinephrine. Crit Care Med 2002, 30:2059-2062. The advantages of vasopressin were also shown in gas exchange in the early postresuscitation phase.
29. Wenzel V, Linder KH, Krismer AC, et al.: Repeated administration of vasopressin but not epinephrine maintains coronary perfusion pressure after early and late administration during prolonged cardiopulmonary resuscitation in pigs. Circulation 1999, 99:1379-1384.
30. Krismer AC, Wenzel V, Voelckel WG, et al.: Effects of vasopressin on adrenal gland regional perfusion during experimental cardiopulmonary resuscitation. Resuscitation 2003, 56:223-228. The adrenal gland plays an important role during cardiac arrest. In comparison with epinephrine, vasopressin produced significantly greater medullary and cortical adrenal gland perfusion during CPR.
31. Wenzel V, Linder KH, Krismer AC, et al.: Survival with full neurologic recovery and no cerebral pathology after prolonged cardiopulmonary resuscitation with vasopressin in pigs. J Am Coll Cardiol 2000, 35:527-533.
32. Kono S, Bito H, Suzuki S, et al.: Vasopressin and epinephrine are equally effective for CPR in a rat asphyxia model. Resuscitation 2002, 52:215-219. Vasopressin exerts the same effectiveness as epinephrine for CPR in the asphyxia model with different myocardial pathology from the ventricular fibrillation model.
33. Lindner KH, Prengel AW, Brinkmann A, et al.: Vasopressin administration in refractory cardiac arrest. Ann Intern Med 1996, 124:1061-1064.
34. Lindner KH, Dirks B, Strohmenger HU: Randomized comparison of epinephrine and vasopressin in patients with out-of-hospital ventricular fibrillation. Lancet 1997, 349:535-538.
35. Prengel AW, Lindner KH, Keller A, et al.: Cardiovascular function during the post-resuscitation phase after cardiac arrest in pigs: a comparison of epinephrine versus vasopressin. Crit Care Med 1996, 24:2014-2019.
36. Wenzel V, Lindner KH: Arginine vasopressin during cardiopulmonary resuscitation: laboratory evidence, clinical experience and recommendations, and a view to the future. Crit Care Med 2002, 30:S157-S161.
37. Lindner KH, Prengel AW, Pfenninger EG, et al.: Angiotensin II augments reflex activity of the sympathetic nervous system during cardiopulmonary resuscitation in pigs. Circulation 1995, 92:1020-1025.
38. Lindner KH, Prengel AW, Pfenninger EG, et al.: Effect of angiotensin II on myocardial blood flow and acid-base status in a pig model of cardiopulmonary resuscitation. Anesth Analg 1993, 76:485-492.
39. Little CM, Hobson JL, Brown CG: Angiotensin II effects in a swine model of cardiac arrest. Ann Emerg Med 1993, 22:244-247.
40. Little CM, Hobson JL, Brown CG: Angiotensin II improves myocardial blood flow in cardiac arrest. Resuscitation 1993, 26:203-210.
41. DeBehnke DJ, Spreng D, Wickman LL, et al.: The effects of endothelin-1 on coronary perfusion pressure during cardiopulmonary resuscitation in a canine model. Acad Emerg Med 1996, 3:137-141.
42. DeBehnke DJ: The effect of graded doses of endothelin-1 on coronary perfusion pressure and vital organ blood flow during cardiac arrest. Acad Emerg Med 2000, 7:211-221.
43. DeBehnke DJ, Benson L: Effect of endothelin-1 on resuscitation rate during cardiac arrest. Resuscitation 2000, 47:185-189.
44. Holzer M, Sterz F, Behringer W, et al.: Endothelin-1 elevates regional cerebral perfusion during prolonged ventricular fibrillation cardiac arrest in pigs. Resuscitation 2002, 55:317-327. The study demonstrated that intravenous application of endothelin-1 during resuscitation increased regional cerebral perfusion and was superior to adrenaline in pigs. Furthermore, resuscitation success increased with moderate doses of endothelin-1.
45. Hilwig RW, Berg RA, Kern KB, et al.: Endothelin-1 vasoconstriction during swine cardiopulmonary resuscitation improves coronary perfusion pressures but worsens postresuscitation outcome. Circulation 2000, 101:2097-2102. An increased postresuscitation mortality after CPR with endothelin-1 in pigs was reported, which was assumed to be the result of postischemic cerebral reperfusion disturbances induced by long-lasting cerebral vasoconstriction after endothelin-1 application.
46. Krep H, Brinker G, Schwindt W, et al.: Endothelin type A-antagonist improves long-term neurological recovery after cardiac arrest in rats. Crit Care Med 2000, 28:2873-2880.
47. Krep H, Brinker G, Pillekamp F, et al.: Treatment with an endothelin type A receptor-antagonist after cardiac arrest and resuscitation improves cerebral hemodynamic and functional recovery in rats. Crit Care Med 2000, 28:2866-2872. Administration of endothelin receptor-antagonist could improve postresuscitation outcome.