Synthesis and evaluation of unsymmetrical polyamine derivatives as antitumor agents

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 14, 2008, Pages 7005-7012

  Wang, Jianhong ^a,b   Xie, Songqiang ^a   Li, Yanjie ^a   Guo, Yongjun ^c   Ma, Yuanfang ^a   Zhao, Jin ^a   Phanstiel IV, Otto ^d   Wang, Chaojie ^a  

^a HENAN UNIVERSITY   (China)

^b Key Laboratory of Special Functional Materials   (China)

^c LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^d UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

Antitumor; Cytotoxicity; Synthesis; Unsymmetrical polyamine conjugate

Indexed keywords

ALKYL GROUP; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING); FLUOROURACIL; N1 (ANTHRACEN 9 YLMETHYL) N4 4 (ETHYLAMINO)BUTYLBUTANE 1,4 DIAMINE TRIHYDROCHLORIDE; N1 ANTHRACENYLHOMOSPERMIDINE; ORNITHINE DECARBOXYLASE; POLYAMINE DERIVATIVE; SPERMIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONJUGATION; DRUG INHIBITION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE II; HUMANS; MICE; NEOPLASMS, EXPERIMENTAL; ORNITHINE DECARBOXYLASE; POLYAMINES; SPERMIDINE; SURVIVAL RATE;

MUS;

EID: 48949115614     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.05.035     Document Type: Article

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