Mixed tetraoxanes containing the acetone subunit as antimalarials

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 14, 2008, Pages 7039-7045

  Opsenica, Dejan M ^a   Terzić, Nataša ^a   Smith, Philip L ^b   Yang, Youngsun ^b   Anova, Lalaine ^b   Smith, Kirsten S ^b   Šolaja, Bogdan A ^c  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Antimalarials; Antiproliferatives; Cholic acid; Metabolic stability; Mixed steroidal tetraoxanes

Indexed keywords

7ALPHA,12ALPHA DIACETOXY 5BETA CHOLAN 24 AMIDE 3 SPIRO 6' (3',3' DIMETHYL 1',2',4',5' TETRAOXACYCLOHEXANE); 7ALPHA,12ALPHA DIACETOXY 5BETA CHOLAN 24 HYDRAZIDE 3 SPIRO 6' (3',3' DIMETHYL 1',2',4',5' TETRAOXACYCLOHEXANE); 7ALPHA,12ALPHA DIACETOXY 5BETA CHOLAN 24 OIC ACID 3 SPIRO 6' (3',3' DIMETHYL 1',2',4',5' TETRAOXACYCLOHEXANE); 7ALPHA,12ALPHA DIHYDROXY 5BETA CHOLAN 24 AMIDE 3 SPIRO 6' (3',3' DIMETHYL 1',2',4',5' TETRAOXACYCLOHEXANE); ACETONE; ANTIMALARIAL AGENT; ARTEMISININ; CHLOROQUINE; CHOLIC ACID; MEFLOQUINE; METHYL 7ALPHA,12ALPHA DIACETOXY 5BETA CHOLAN 24 OATE 3 SPIRO 6' (3',3' DIMETHYL 1',2',4',5' TETRAOXACYCLOHEXANE); N (2 DIMETHYLAMINO)ETHYL 7ALPHA,12ALPHA DIACETOXY 5BETA CHOLAN 24 AMIDE 3 SPIRO 6' (3',3' DIMETHYL 1',2',4',5' TETRAOXACYCLOHEXANE); N (METHOXYCARBONYLETHYL) 7ALPHA,12ALPHA DIACETOXY 5BETA CHOLAN 24 AMIDE 3 SPIRO 6' (3',3'-DIMETHYL 1',2',4',5' TETRAOXACYCLOHEXANE); N METHYL 7ALPHA,12ALPHA DIACETOXY 5BETA CHOLAN 24 AMIDE 3 SPIRO 6' (3',3' DIMETHYL 1',2',4',5' TETRAOXACYCLOHEXANE); N PHENYL 7ALPHA,12ALPHA DIACETOXY 5BETA CHOLAN 24 AMIDE 3 SPIRO 6' (3',3' DIMETHYL 1',2',4',5' TETRAOXACYCLOHEXANE); N PROPYL 7ALPHA,12ALPHA DIACETOXY 5BETA CHOLAN 24 AMIDE 3 SPIRO 6' (3',3' DIMETHYL 1',2',4',5' TETRAOXACYCLOHEXANE); N,N DIMETHYL 7ALPHA,12ALPHA DIACETOXY 5BETA CHOLAN 21 AMIDE 3 SPIRO 6' (3',3' DIMETHYL 1',2',4',5' TETRAOXACYCLOHEXANE); TETRAOXANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG MEGADOSE; DRUG METABOLISM; DRUG POTENCY; DRUG SCREENING; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MALARIA; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PLASMODIUM FALCIPARUM;

ACETONE; ANIMALS; ANTIMALARIALS; ARTEMISININS; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, MULTIPLE; MEFLOQUINE; MICE; PLASMODIUM FALCIPARUM; TETRAOXANES;

MUS;

EID: 48949115566     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.05.017     Document Type: Article

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