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Volumn 1, Issue 13, 2008, Pages

Silent assassin: Oncogenic Ras directs epigenetic inactivation of target genes

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Indexed keywords

PROTEIN P21;

EID: 48849083854     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/stke.113pe14     Document Type: Review
Times cited : (8)

References (33)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • D. Hanahan, R. A. Weinberg, The hallmarks of cancer. Cell 100, 57-70 (2000).
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 35548953686 scopus 로고    scopus 로고
    • An elaborate pathway required for Ras-mediated epigenetic silencing
    • C. Gazin, N. Wajapeyee, S. Gobeil, C. M. Virbasius, M. R. Green, An elaborate pathway required for Ras-mediated epigenetic silencing. Nature 449, 1073-1077 (2007).
    • (2007) Nature , vol.449 , pp. 1073-1077
    • Gazin, C.1    Wajapeyee, N.2    Gobeil, S.3    Virbasius, C.M.4    Green, M.R.5
  • 3
    • 15744401773 scopus 로고    scopus 로고
    • Eukaryotic cytosine methyltransferases
    • M. G. Goll, T. H. Bestor, Eukaryotic cytosine methyltransferases. Annu. Rev. Biochem. 74, 481-514 (2005).
    • (2005) Annu. Rev. Biochem , vol.74 , pp. 481-514
    • Goll, M.G.1    Bestor, T.H.2
  • 4
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • A. P. Feinberg, B. Vogelstein, Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301, 89-92 (1983).
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 5
    • 0021950948 scopus 로고
    • Hypomethylation of DNA from benign and malignant human colon neoplasms
    • S. E. Goelz, B. Vogelstein, S. R. Hamilton, A. P. Feinberg, Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 228, 187-190 (1985).
    • (1985) Science , vol.228 , pp. 187-190
    • Goelz, S.E.1    Vogelstein, B.2    Hamilton, S.R.3    Feinberg, A.P.4
  • 6
    • 0023848637 scopus 로고
    • Reduced genomic 5-methylcytosine content in human colonic neoplasia
    • A. P. Feinberg, C. W. Gehrke, K. C. Kuo, M. Ehrlich, Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res. 48, 1159-1161 (1988).
    • (1988) Cancer Res , vol.48 , pp. 1159-1161
    • Feinberg, A.P.1    Gehrke, C.W.2    Kuo, K.C.3    Ehrlich, M.4
  • 7
    • 0037068353 scopus 로고    scopus 로고
    • DNA methylation in cancer: Too much, but also too little
    • M. Ehrlich, DNA methylation in cancer: Too much, but also too little. Oncogene 21, 5400-5413 (2002).
    • (2002) Oncogene , vol.21 , pp. 5400-5413
    • Ehrlich, M.1
  • 8
    • 0021748312 scopus 로고
    • Hypomethylation of DNA in human cancer cells: A site-specific change in the c-myc oncogene
    • M. S. Cheah, C. D. Wallace, R. M. Hoffman, Hypomethylation of DNA in human cancer cells: A site-specific change in the c-myc oncogene. J. Natl. Cancer Inst. 73, 1057-1065 (1984).
    • (1984) J. Natl. Cancer Inst , vol.73 , pp. 1057-1065
    • Cheah, M.S.1    Wallace, C.D.2    Hoffman, R.M.3
  • 9
    • 16844384464 scopus 로고    scopus 로고
    • Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays
    • M. Nishigaki, K. Aoyagi, I. Danjoh, M. Fukaya, K. Yanagihara, H. Sakamoto, T. Yoshida, H. Sasaki, Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. Cancer Res. 65, 2115-2124 (2005).
    • (2005) Cancer Res , vol.65 , pp. 2115-2124
    • Nishigaki, M.1    Aoyagi, K.2    Danjoh, I.3    Fukaya, M.4    Yanagihara, K.5    Sakamoto, H.6    Yoshida, T.7    Sasaki, H.8
  • 10
    • 0037038684 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivityin K-ras mutant pancreatic cancer cell line MIA PaCa-2
    • R. A. Alcock, S. Dey, D. Chendil, M. S. Inayat, M. Mohiuddin, G. Hartman, L. K. Chatfield, V. S. Gallicchio, M. M. Ahmed, Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivityin K-ras mutant pancreatic cancer cell line MIA PaCa-2. Oncogene 21, 7883-7890 (2002).
    • (2002) Oncogene , vol.21 , pp. 7883-7890
    • Alcock, R.A.1    Dey, S.2    Chendil, D.3    Inayat, M.S.4    Mohiuddin, M.5    Hartman, G.6    Chatfield, L.K.7    Gallicchio, V.S.8    Ahmed, M.M.9
  • 12
    • 29244447111 scopus 로고    scopus 로고
    • Loss of imprinting of IGF2: A common epigenetic modifier of intestinal tumor risk
    • A. Kaneda, A. P. Feinberg, Loss of imprinting of IGF2: A common epigenetic modifier of intestinal tumor risk. Cancer Res. 65, 11236-11240 (2005).
    • (2005) Cancer Res , vol.65 , pp. 11236-11240
    • Kaneda, A.1    Feinberg, A.P.2
  • 13
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal instability and tumors promoted by DNA hypomethylation
    • A. Eden, F. Gaudet, A. Waghmare, R. Jaenisch, Chromosomal instability and tumors promoted by DNA hypomethylation. Science 300, 455 (2003).
    • (2003) Science , vol.300 , pp. 455
    • Eden, A.1    Gaudet, F.2    Waghmare, A.3    Jaenisch, R.4
  • 16
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • J. L. Bos, Ras oncogenes in human cancer: A review. Cancer Res. 49, 4682-4689 (1989).
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 17
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • J. Downward, Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3, 11-22 (2003).
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 18
    • 0032146779 scopus 로고    scopus 로고
    • Inhibition of Fas (CD95) expression and Fas-mediated apoptosis by oncogenic Ras
    • R. G. Fenton, J. A. Hixon, P. W. Wright, A. D. Brooks, T. J. Sayers, Inhibition of Fas (CD95) expression and Fas-mediated apoptosis by oncogenic Ras. Cancer Res. 58, 3391-3400 (1998).
    • (1998) Cancer Res , vol.58 , pp. 3391-3400
    • Fenton, R.G.1    Hixon, J.A.2    Wright, P.W.3    Brooks, A.D.4    Sayers, T.J.5
  • 19
    • 0345148793 scopus 로고    scopus 로고
    • Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas
    • J. Peli, M. Schroter, C. Rudaz, M. Hahne, C. Meyer, E. Reichmann, J. Tschopp, Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas. EMBO J. 18, 1824-1831 (1999).
    • (1999) EMBO J , vol.18 , pp. 1824-1831
    • Peli, J.1    Schroter, M.2    Rudaz, C.3    Hahne, M.4    Meyer, C.5    Reichmann, E.6    Tschopp, J.7
  • 20
    • 0032937784 scopus 로고    scopus 로고
    • Association of K-ras mutations with p16 methylation in human colon cancer
    • R. J. Guan, Y. Fu, P. R. Holt, A. B. Pardee, Association of K-ras mutations with p16 methylation in human colon cancer. Gastroenterology 116, 1063-1071 (1999).
    • (1999) Gastroenterology , vol.116 , pp. 1063-1071
    • Guan, R.J.1    Fu, Y.2    Holt, P.R.3    Pardee, A.B.4
  • 21
    • 0032984911 scopus 로고    scopus 로고
    • Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene
    • S. Contente, K. Kenyon, P. Sriraman, S. Subramanyan, R. M. Friedman, Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene. Mol. Cell. Biochem. 194, 79-91 (1999).
    • (1999) Mol. Cell. Biochem , vol.194 , pp. 79-91
    • Contente, S.1    Kenyon, K.2    Sriraman, P.3    Subramanyan, S.4    Friedman, R.M.5
  • 22
    • 20744447485 scopus 로고    scopus 로고
    • RAS mediated loss of the pro-apoptotic response protein par-4 is mediated by DNA hypermethylation through RAF-independent and RAF-dependent signaling cascades in epithelial cells
    • K. Pruitt, A. S. Ulkü, K. Frantz, R. J. Rojas, V. M. Muniz-Medina, V. M. Rangnekar, C. J. Der, J. M. Shields, RAS mediated loss of the pro-apoptotic response protein par-4 is mediated by DNA hypermethylation through RAF-independent and RAF-dependent signaling cascades in epithelial cells. J. Biol. Chem. 280, 23363-23370 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 23363-23370
    • Pruitt, K.1    Ulkü, A.S.2    Frantz, K.3    Rojas, R.J.4    Muniz-Medina, V.M.5    Rangnekar, V.M.6    Der, C.J.7    Shields, J.M.8
  • 23
    • 0036124598 scopus 로고    scopus 로고
    • Opposing roles of the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in Ras-mediated downregulation of tropomyosin
    • J. M. Shields, H. Mehta, K. Pruitt, C. J. Der, Opposing roles of the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in Ras-mediated downregulation of tropomyosin. Mol. Cell. Biol. 22, 2304-2317 (2002).
    • (2002) Mol. Cell. Biol , vol.22 , pp. 2304-2317
    • Shields, J.M.1    Mehta, H.2    Pruitt, K.3    Der, C.J.4
  • 24
    • 33645810141 scopus 로고    scopus 로고
    • RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells
    • F. C. Mei, T.W. Young, J. Liu, X. Cheng, RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells. FASEB J. 20, 497-499 (2006).
    • (2006) FASEB J , vol.20 , pp. 497-499
    • Mei, F.C.1    Young, T.W.2    Liu, J.3    Cheng, X.4
  • 25
    • 0029046134 scopus 로고
    • Regulation of DNA methylation by the Ras signaling pathway
    • A. R. MacLeod, J. Rouleau, M. Szyf, Regulation of DNA methylation by the Ras signaling pathway. J. Biol. Chem. 270, 11327-11337 (1995).
    • (1995) J. Biol. Chem , vol.270 , pp. 11327-11337
    • MacLeod, A.R.1    Rouleau, J.2    Szyf, M.3
  • 26
    • 2342457639 scopus 로고    scopus 로고
    • Transcription repression in oncogenic transformation: Common targets of epigenetic repression in cells transformed by Fos
    • J. M. Ordway, K. Williams, T. Curran, Transcription repression in oncogenic transformation: common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1. Oncogene 23, 3737-3748 (2004).
    • (2004) Ras or Dnmt1. Oncogene , vol.23 , pp. 3737-3748
    • Ordway, J.M.1    Williams, K.2    Curran, T.3
  • 31
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • M. Serrano, A.W. Lin, M. E. McCurrach, D. Beach, S. W. Lowe, Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602 (1997).
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 32
    • 4344646902 scopus 로고    scopus 로고
    • Species- and cell type-specific requirements for cellular transformation
    • A. Rangarajan, S. J. Hong, A. Gifford, R. A.Weinberg, Species- and cell type-specific requirements for cellular transformation. Cancer Cell 6, 171-183 (2004).
    • (2004) Cancer Cell , vol.6 , pp. 171-183
    • Rangarajan, A.1    Hong, S.J.2    Gifford, A.3    Weinberg, R.A.4
  • 33
    • 48849083854 scopus 로고    scopus 로고
    • Silent assassin: Oncogenic Ras directs epigenetic inactivation of target genes
    • X. Cheng, Silent assassin: Oncogenic Ras directs epigenetic inactivation of target genes. Sci. Signal. 1, pe14 (2008).
    • (2008) Sci. Signal , vol.1
    • Cheng, X.1


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