Photo-crosslinking of proteins in intact cells reveals a dimeric structure of cyclooxygenase-2 and an inhibitor-sensitive oligomeric structure of microsomal prostaglandin E2 synthase-1

Archives of Biochemistry and Biophysics

Volumn 477, Issue 1, 2008, Pages 155-162

  Hétu, Pierre Olivier ^a,b   Ouellet, Marc ^a   Falgueyret, Jean Pierre ^a   Ramachandran, Chidambaram ^a   Robichaud, Joel ^a   Zamboni, Robert ^a   Riendeau, Denis ^a,b  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Cyclooxygenase 2 (COX 2); Microsomal prostaglandin E2 synthase 1 (mPGES 1); Photo methionine; Prostaglandins; Protein photo crosslinking; Selective mPGES 1 inhibitor

Indexed keywords

CYCLOOXYGENASE 2; DIMER; METHIONINE; PROSTAGLANDIN E2; PROSTAGLANDIN E2 SYNTHASE 1; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; SUBERIC ACID BIS(N HYDROXYSUCCINIMIDE) ESTER; SUCCINIMIDE DERIVATIVE;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DIMERIZATION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MICROSOME; PRIORITY JOURNAL; PROTEIN CROSS LINKING;

BLOTTING, WESTERN; CELL LINE; CYCLOOXYGENASE 2; DIMERIZATION; DINOPROSTONE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; PHOTOCHEMISTRY; PROTEIN CONFORMATION; ULTRAVIOLET RAYS;

EID: 48749112803     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2008.04.038     Document Type: Article

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