Involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in cardiotoxin III-induced apoptosis in HL-60 cells

Clinical and Experimental Pharmacology and Physiology

Volumn 35, Issue 9, 2008, Pages 1059-1064

  Chien, Ching Ming ^a   Yang, Sheng Huei ^a   Chang, Long Sen ^b   Lin, Shinne Ren ^a,b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Calcium; Calpain; Cardiotoxin III; Caspases; Glucose related protein 78 (Grp78); HL 60 cells

Indexed keywords

BENZYLOXYCARBONYLALANYLTHREONYLALANYLASPARTIC ACID FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; BETA ACTIN; CALCIUM; CALPAIN 1; CARDIOTOXIN; CARDIOTOXIN III; CASPASE 12; CASPASE 3; CASPASE 9; CASPASE 9 INHIBITOR; CASPASE INHIBITOR; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; POLYPEPTIDE; PROTEIN BAX; PROTEIN BCL 2; SNAKE VENOM;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CELL STRESS; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; MITOCHONDRION; SIGNAL TRANSDUCTION;

APOPTOSIS; CALCIUM; CALPAIN; CASPASE 12; COBRA CARDIOTOXIN PROTEINS; CYTOCHROMES C; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; HL-60 CELLS; HUMANS; MITOCHONDRIA; MOLECULAR CHAPERONES; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 48749086469     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.04968.x     Document Type: Article

References (36)

1. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X. Biochemical pathways of caspase activation during apoptosis. Annu. Rev. Cell Dev. Biol. 1999 15 : 269 99.
2. Chen M, Wang J. Initiator caspases in apoptosis signaling pathways. Apoptosis 2002 7 : 313 19.
3. Li XA, Guo L, Dressman JL, Asmis R, Smart EJ. A novel ligand-independent apoptotic pathway induced by scavenger receptor class B, type 1 and suppressed by endothelial nitric-oxide synthase and high density lipoprotein. J. Biol. Chem. 2005 280 : 19 087 96.
4. Nakagawa T, Zhu H, Morishima N. Caspase-12 mediated endoplasmic- reticulum-specific-apoptosis and cytotoxicity by β-amyloid. Nature 2000 403 : 98 103.
5. Nakamura K, Bossy-Wetzel E, Burns K et al. Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis. J. Cell Biol. 2000 150 : 731 40.
6. Rao RV, Ellerby HM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ. 2004 11 : 372 80.
7. Hajnoczky G, Davies E, Madesh M. Calcium signaling and apoptosis. Biochem. Biophys. Res. Commun. 2003 304 : 445 54.
8. Lamkanfi M, Kalai M, Vandenabeele P. Caspase-12: An overview. Cell Death Differ. 2004 11 : 365 8.
9. Dufton MJ, Hider RC. The structure and pharmacology of Elapid cytotoxins. In : Harvey AL (ed.). Snake Toxins. Pergamon Press, New York. 1991 259 302.
10. Chien KY, Huang WN, Jean JH, Wu WG. Fusion of sphingomyelin vesicles induced by proteins from Taiwan cobra (Naja naja atra) venom. Interaction of zwitterionic phospholipids with cardiotoxin analogues. J. Biol. Chem. 1991 266 : 3235 59.
11. Chiou SH, Raynor RL, Zheng B, Chambars TC, Kuo JF. Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: Comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and model of enzyme inhibition. Biochemistry 1993 32 : 2062 7.
12. Guo MP, Wang QC, Liu GF. Pharmacokinetics of cytotoxin from Chinese cobra (Naja naja atra) venom. Toxicon 1993 31 : 339 43.
13. Newman RA, Vidal JC, Viskatis LJ, Johnson J, Etcheverry MA. VRCTC-310: A novel compound of purified animal toxins separates antitumor efficacy from neurotoxicity. Invest. New Drugs 1993 111 : 151 9.
14. DeTolla LJ, Stump KC, Russell R et al. Toxicity of the novel animal-derived anticancer agent, VRCTC-310: Acute and subchronic studies in beagle dogs. Toxicology 1995 99 : 31 46.
15. Yang SH, Chien CM, Lu MC, Lu YL, Wu ZZ, Lin SR. Cardiotoxin III induces apoptosis in K562 cells through a mitochondrial-mediated pathway. Clin. Exp. Pharmacol. Physiol. 2005 32 : 515 20.
16. Yang SH, Lu MC, Chien CM et al. Induction of apoptosis in human leukemia K562 cells by cardiotoxin III. Life Sci. 2005 76 : 2513 22.
17. Lin SR, Chang LS, Chang KL. Separation and structure-function studies of Taiwan cobra cardiotoxins. J. Protein Chem. 2002 21 : 81 6.
18. Hail Jr. N, Konopleva M, Sporn M, Lotan R, Andreeff M. Evidence supporting a role for calcium in apoptosis induction by the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO). J. Biol. Chem. 2004 279 : 179 87.
19. Lee AS. The glucose-regulated proteins: Stress induction and clinical applications. Trends Biochem. Sci. 2001 26 : 504 10.
20. Nakagawa T, Yuan J. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J. Cell Biol. 2000 150 : 887 94.
21. Bajaj G, Sharma RK. TNF-alpha-mediated cardiomyocyte apoptosis involves caspase-12 and calpain. Biochem. Biophys. Res. Commun. 2006 345 : 1558 64.
22. Adams JM, Cory S. The Bcl-2 protein family: Arbiters of cell survival. Science 1998 281 : 1322 6.
23. Antonsson B, Martinou JC. The Bcl-2 protein family. Exp. Cell Res. 2000 256 : 50 7.
24. Rao RV, Hermel E, Castro-Obregon S et al. Coupling endoplasmic reticulum stress to the cell death program: Mechanism of caspase activation. J. Biol. Chem. 2001 276 : 869 74.
25. 2+-dependent caspase-12 activation. Life Sci. 2006 78 : 1892 9.
26. Kuo PL, Hsu YL, Cho CY, Ng LT, Kuo YH, Lin CC. Apoptotic effects of Antrodia cinnamomea fruiting bodies extract are mediated through calcium and calpain-dependent pathways in Hep 3B cells. Food Chem. Toxicol. 2006 44 : 1316 26.
27. 2+-mediated, calpain/caspase-12-dependent apoptosis in breast cancer cells. Biochem. Biophys. Res. Commun. 2004 321 : 462 7.
28. Wertz IE, Dixit VM. Characterization of calcium release-activated apoptosis of LNCaP prostate cancer cells. J. Biol. Chem. 2000 275 : 470 7.
29. Pastorino JG, Chen ST, Tafani M, Snyder JW, Farber JL. The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J. Biol. Chem. 1998 273 : 7770 5.
30. Robertson JD, Orrenius S. Molecular mechanisms of apoptosis induced by cytotoxic chemicals. Crit. Rev. Toxicol. 2000 30 : 609 27.
31. L involved in cardiotoxin III-induced apoptosis in K562 cell. Exp. Mol. Med. 2006 38 : 435 44.
32. Morishima N, Nakanishi K, Takenouchi H, Shibata T, Yasuhiko Y. An endoplasmic reticulum stress-specific caspase cascade in apoptosis: Cytochrome c-independent activation of caspase-9 by caspase-12. J. Biol. Chem. 2002 277 : 287 94.
33. Hacki J, Egger L, Monney L et al. Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2. Oncogene 2000 19 : 2286 95.
34. Kitamura Y, Miyamura A, Takata K et al. Possible involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in thapsigargin-induced apoptosis in human neuroblastoma SH-SY5Y cells. J. Pharmacol. Sci. 2003 92 : 228 36.
35. Ito Y, Pandey P, Mishra N et al. Targeting of the c-Abl tyrosine kinase to mitochondria in endoplasmic reticulum stress-induced apoptosis. Mol. Cell. Biol. 2001 21 : 6233 42.
36. Rao RV, Peel A, Logvinova A et al. Coupling endoplasmic reticulum stress to the cell death program: Role of the ER chaperone GRP78. FEBS Lett. 2002 514 : 122 8.