Synthesis and SAR of a new series of COX-2-selective inhibitors: Pyrazolo[1,5-α]pyrimidines

Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2001, Pages 350-361

  Almansa, C ^a   De Arriba, A F ^a   Cavalcanti, F L ^a   Gomez L A ^a   Miralles, A ^a   Merlos, M ^a   Garcia Rafanell J ^a   Forn, J ^a  

^a Grupo Uriach   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 FLUOROPHENYL) 6,7 DIMETHYL 2 (4 METHYLSULFONYLPHENYL)PYRAZOLO[1,5 A]PYRIMIDINE; CARRAGEENAN; CYCLOOXYGENASE 2 INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; PYRAZOLO[1,5 A]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; INFLAMMATION; MALE; NONHUMAN; PAW EDEMA; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CELL LINE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; EDEMA; ENZYME INHIBITORS; EXUDATES AND TRANSUDATES; HUMANS; ISOENZYMES; MALE; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; PYRIMIDINES; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; STOMACH; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035253874     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0009383     Document Type: Article

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