3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinoline-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: Chemical synthesis, evaluation in vitro and radiofluorination

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4727-4730

  Funke, Uta ^a   Fischer, Steffen ^a   Hiller, Achim ^a   Scheunemann, Matthias ^a   Deuther Conrad, Winnie ^a   Brust, Peter ^a   Steinbach, Jörg ^a  

^a Institut fur Interdisziplinare Isotopenforschung   (Germany)

Author keywords

Affinity; Fluorine 18; Indole carbonitriles; PET; Radiolabeling; Serotonin transporter

Indexed keywords

3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; CITALOPRAM; FLUORODEOXYGLUCOSE F 18; ISOQUINOLINE DERIVATIVE; NISOXETINE; PAROXETINE; SEROTONIN TRANSPORTER; TRACER;

ALKYLATION; ARTICLE; DRUG BINDING; DRUG RETENTION; DRUG SCREENING; DRUG SYNTHESIS; EMBRYO; FLUORINATION; HUMAN; HUMAN CELL; IMAGING; IN VITRO STUDY; POSITRON EMISSION TOMOGRAPHY;

CARBON; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; DRUG DESIGN; FLUORINE RADIOISOTOPES; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; KINETICS; MEMBRANE TRANSPORT PROTEINS; MODELS, CHEMICAL; NITRILES; QUINOLINES; RADIOPHARMACEUTICALS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 48649096714     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.06.077     Document Type: Article

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