Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 14, 2001, Pages 1885-1888

  Meagher, Kristin L ^a   Mewshaw, Richard E ^a   Evrard, Deborah A ^a   Zhou, Ping ^a   Smith, Deborah L ^a   Scerni, Rosemary ^a   Spangler, Taylor ^a   Abulhawa, Susan ^a   Shi, Xiaojie ^a   Schechter, Lee E ^a   Andree, Terrance H ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; BENZYLAMINE DERIVATIVE; CYCLOHEXYLAMINE DERIVATIVE; INDOLE DERIVATIVE; INDOLYLCYCLOHEXYLAMINE DERIVATIVE; PHENETHYLAMINE DERIVATIVE; PIPERIDINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION; CIS ISOMER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; HUMAN; NONHUMAN; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; SEROTONINERGIC TRANSMISSION; STRUCTURE ACTIVITY RELATION; TRANS ISOMER;

ANIMALS; ANTIDEPRESSIVE AGENTS; CARRIER PROTEINS; CHO CELLS; CRICETINAE; CYCLOHEXYLAMINES; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; RATS; RECEPTORS, ADRENERGIC, ALPHA; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035939309     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00334-1     Document Type: Article

References (20)