메뉴 건너뛰기




Volumn 10, Issue 10, 1998, Pages 3127-3140

The effects of anti-nerve growth factor monoclonal antibodies on developing basal forebrain neurons are transient and reversible

Author keywords

Antibody anti nerve growth factor; Basal forebrain; Cholinacetyltransferase; Cholinergic system; Development; Nerve growth factor; Neurotrophin; TrkA; TrkB

Indexed keywords

CHOLINE ACETYLTRANSFERASE; MONOCLONAL ANTIBODY; NERVE GROWTH FACTOR ANTIBODY; PROTEIN TYROSINE KINASE;

EID: 0032447208     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1998.00314.x     Document Type: Article
Times cited : (38)

References (57)
  • 1
    • 0025168085 scopus 로고
    • Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture
    • Alderson, R.F., Alterman, A.L., Barde, Y.-A. & Lindsay, R.M. (1990) Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture. Neuron, 5, 297-306.
    • (1990) Neuron , vol.5 , pp. 297-306
    • Alderson, R.F.1    Alterman, A.L.2    Barde, Y.-A.3    Lindsay, R.M.4
  • 2
    • 0343034898 scopus 로고
    • Effects of nt-4, bdnf or ngf on the survival and phenotypic differentiation of septal cholinergic neurons
    • Alderson, R.F., Alterman, A.L., Morissey, D. & Lindsay, R.M. (1993) Effects of NT-4, BDNF or NGF on the survival and phenotypic differentiation of septal cholinergic neurons. Trans. Am. Soc. Neurosci., 19, 666-672.
    • (1993) Trans. Am. Soc. Neurosci. , vol.19 , pp. 666-672
    • Alderson, R.F.1    Alterman, A.L.2    Morissey, D.3    Lindsay, R.M.4
  • 4
    • 0010460201 scopus 로고    scopus 로고
    • Cholinergic function in the hippocampus of juvenile rats chronically deprived of ngf: An electrophysiological study
    • Avignone, E., Molnar, M., Cattaneo, A., Sciancalepore, M. & Cherubini, E. (1996) Cholinergic function in the hippocampus of juvenile rats chronically deprived of NGF: an electrophysiological study. Soc. Neurosci. Abstr., 22, 754.
    • (1996) Soc. Neurosci. Abstr. , vol.22 , pp. 754
    • Avignone, E.1    Molnar, M.2    Cattaneo, A.3    Sciancalepore, M.4    Cherubini, E.5
  • 6
    • 0019190543 scopus 로고
    • Sensory neurons in culture: Changing requirements for survival factors during embryonic development
    • Barde, Y.A., Edgar, D. & Thoenen, H. (1980) Sensory neurons in culture: Changing requirements for survival factors during embryonic development. Proc. Natl Acad. Sci. USA, 77, 119-1203.
    • (1980) Proc. Natl Acad. Sci. USA , vol.77 , pp. 119-1203
    • Barde, Y.A.1    Edgar, D.2    Thoenen, H.3
  • 7
    • 0024332481 scopus 로고
    • Nerve growth factor receptor and cholin acetyltrasferase colocalization in neurons within the rat forebrain: Response to fimbria-fornix transection
    • Batchelor, P.E., Armstrong, D.M., Blaker, S.N. & Gage, F.G. (1989) Nerve growth factor receptor and cholin acetyltrasferase colocalization in neurons within the rat forebrain: response to fimbria-fornix transection. J. Comp. Neurol., 284, 187-204.
    • (1989) J. Comp. Neurol. , vol.284 , pp. 187-204
    • Batchelor, P.E.1    Armstrong, D.M.2    Blaker, S.N.3    Gage, F.G.4
  • 9
    • 0014584518 scopus 로고
    • The nerve growth factor purification as a 30,000-molecular weight protein
    • Bocchini, V. & Angeletti, P.U. (1969) The nerve growth factor purification as a 30,000-molecular weight protein. Proc. Natl Acad. Sci. USA, 64, 787-794.
    • (1969) Proc. Natl Acad. Sci. USA , vol.64 , pp. 787-794
    • Bocchini, V.1    Angeletti, P.U.2
  • 10
    • 0028829061 scopus 로고
    • Monocular deprivation decreases the expression of messenger rna for brain-derived neurotrophic factor in the rat visual cortex
    • Bozzi, Y., Pizzorusso, T., Cremisi, F., Rossi, F.M., Barsacchi, G. & Maffei, L. (1995) Monocular deprivation decreases the expression of messenger RNA for brain-derived neurotrophic factor in the rat visual cortex. Neuroscience, 69, 1133-1144.
    • (1995) Neuroscience , vol.69 , pp. 1133-1144
    • Bozzi, Y.1    Pizzorusso, T.2    Cremisi, F.3    Rossi, F.M.4    Barsacchi, G.5    Maffei, L.6
  • 11
    • 0023950479 scopus 로고
    • Three distinct types of monoclonal antibodies after long term immunization of rats with mouse ngf
    • Cattaneo, A., Raposelli, B. & Calissano, P. (1988) Three distinct types of monoclonal antibodies after long term immunization of rats with mouse NGF. J. Neurochem., 50, 1003-1010.
    • (1988) J. Neurochem. , vol.50 , pp. 1003-1010
    • Cattaneo, A.1    Raposelli, B.2    Calissano, P.3
  • 12
    • 0030799383 scopus 로고    scopus 로고
    • Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits
    • Chen, K.S., Nishimura, M.C., Armanini, M.P., Crowley, C., spencer, S.D. & Philips, H.S. (1997) Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits. J. Neurosci., 17, 7288-7296.
    • (1997) J. Neurosci. , vol.17 , pp. 7288-7296
    • Chen, K.S.1    Nishimura, M.C.2    Armanini, M.P.3    Crowley, C.4    Spencer, S.D.5    Philips, H.S.6
  • 14
    • 84992570673 scopus 로고    scopus 로고
    • Spatial learning and cholinergic function in adult rats implanted with hybridoma cells secreting neutralizing antibodies to ngf
    • Costagliola, R.M., Cenni, M.C., Casamenti, F., Cattaneo, A., Maffei, L. & Berardi, N. (1997) Spatial learning and cholinergic function in adult rats implanted with hybridoma cells secreting neutralizing antibodies to NGF. Soc. Neurosci. Abstr., 27, 877.3.
    • (1997) Soc. Neurosci. Abstr. , vol.27 , pp. 877.3
    • Costagliola, R.M.1    Cenni, M.C.2    Casamenti, F.3    Cattaneo, A.4    Maffei, L.5    Berardi, N.6
  • 16
    • 0031017281 scopus 로고    scopus 로고
    • The yin and yang of nerve growth factor
    • Davies, A.M. (1997a) The yin and yang of nerve growth factor. Curr. Biol., 7, 38-40.
    • (1997) Curr. Biol. , vol.7 , pp. 38-40
    • Davies, A.M.1
  • 17
    • 0031056811 scopus 로고    scopus 로고
    • Neurotrophin switching: Where does it stand
    • Davies, A.M. (1997b) Neurotrophin switching: Where does it stand? Curr. Op. Neurobiol., 7, 110-118.
    • (1997) Curr. Op. Neurobiol. , vol.7 , pp. 110-118
    • Davies, A.M.1
  • 18
  • 19
    • 0028534861 scopus 로고
    • Nerve growth factor (ngf) uptake and transport following injection in the developing rat visual cortex
    • Domenici, L., Fontanesi, G., Cattaneo, A., Bagnoli, P. & Maffei, L. (1994a) Nerve growth factor (NGF) uptake and transport following injection in the developing rat visual cortex. Vis. Neurosci., 11, 1093-1102.
    • (1994) Vis. Neurosci. , vol.11 , pp. 1093-1102
    • Domenici, L.1    Fontanesi, G.2    Cattaneo, A.3    Bagnoli, P.4    Maffei, L.5
  • 20
    • 0028130509 scopus 로고
    • Antibodies to nerve growth factor (ngf) prolong the sensitive period for monocular deprivation in the rat
    • Domenici, L., Cellerino, A., Berardi, N., Cattaneo, A. & Maffei, L. (1994b) Antibodies to nerve growth factor (NGF) prolong the sensitive period for monocular deprivation in the rat. NeuroReport, 5, 2041-2044.
    • (1994) Neuroreport , vol.5 , pp. 2041-2044
    • Domenici, L.1    Cellerino, A.2    Berardi, N.3    Cattaneo, A.4    Maffei, L.5
  • 21
    • 0028904180 scopus 로고
    • The septohippocampal pathway: Structure and function of a central cholinergic system
    • Dutar, P., Bassant, M.E., Sen, M. & Lamour, Y. (1995) The septohippocampal pathway: structure and function of a central cholinergic system. Physiol. Rev., 75, 393-427.
    • (1995) Physiol. Rev. , vol.75 , pp. 393-427
    • Dutar, P.1    Bassant, M.E.2    Sen, M.3    Lamour, Y.4
  • 22
    • 0030761205 scopus 로고    scopus 로고
    • A role for trka during maturation of striatal and basal forebrain cholinergic neurons in vivo
    • Fagan, A.M., Garber, M., Barbacid, M., Silos-Santiago, I. & Holtzman, D.M. (1997) A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo. J. Neurosci., 17, 7644-7654.
    • (1997) J. Neurosci. , vol.17 , pp. 7644-7654
    • Fagan, A.M.1    Garber, M.2    Barbacid, M.3    Silos-Santiago, I.4    Holtzman, D.M.5
  • 25
    • 0030919181 scopus 로고    scopus 로고
    • Learning impairment and cholinergic deafferentation after cortical nerve growth factor deprivation
    • Guitierrez, H., Miranda, M.I. & Bermudez-Rattoni, F. (1997) Learning impairment and cholinergic deafferentation after cortical nerve growth factor deprivation. J. Neurosci., 17, 3796-3803.
    • (1997) J. Neurosci. , vol.17 , pp. 3796-3803
    • Guitierrez, H.1    Miranda, M.I.2    Bermudez-Rattoni, F.3
  • 26
    • 0022486717 scopus 로고
    • Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
    • Hefti, F. (1986) Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. J. Neurosci., 6, 2155-2162.
    • (1986) J. Neurosci. , vol.6 , pp. 2155-2162
    • Hefti, F.1
  • 27
    • 0026468503 scopus 로고
    • Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation
    • Hempstead, B.L., Rabin, S.J., Kaplan, L., Reid, S., Parada, L.F. & Kaplan, D.R. (1992) Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation. Neuron, 9, 883-896.
    • (1992) Neuron , vol.9 , pp. 883-896
    • Hempstead, B.L.1    Rabin, S.J.2    Kaplan, L.3    Reid, S.4    Parada, L.F.5    Kaplan, D.R.6
  • 29
    • 0026723604 scopus 로고
    • Somatic gene transfer of nerve growth factor of axotomized septal neurons and the regeneration of their axons in adult rats
    • Kawaja, M.D., Rosenberg, M.B., Yoshida, J. & Gage, F.H. (1992) Somatic gene transfer of nerve growth factor of axotomized septal neurons and the regeneration of their axons in adult rats. J. Neurosci., 12, 2849-2864.
    • (1992) J. Neurosci. , vol.12 , pp. 2849-2864
    • Kawaja, M.D.1    Rosenberg, M.B.2    Yoshida, J.3    Gage, F.H.4
  • 30
    • 0025265681 scopus 로고
    • Selective and non selective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, epidermal growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors i and ii
    • Knüsel, B., Michel, P., Swaber, J.S. & Hefti, F. (1990) Selective and non selective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, epidermal growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II. J. Neurosci., 10, 558-570.
    • (1990) J. Neurosci. , vol.10 , pp. 558-570
    • Knüsel, B.1    Michel, P.2    Swaber, J.S.3    Hefti, F.4
  • 31
    • 0026022504 scopus 로고
    • Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin-3
    • Knüsel, B., Winslow, J.W., Rosenthal, A., Burton, L.E., Seid, P., Nikolics, K. & Hefti, F. (1991) Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin-3. Proc. Natl Acad. Sci. USA, 88, 961-965.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 961-965
    • Knüsel, B.1    Winslow, J.W.2    Rosenthal, A.3    Burton, L.E.4    Seid, P.5    Nikolics, K.6    Hefti, F.7
  • 32
    • 0026574673 scopus 로고
    • Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain
    • Knüsel, B., Winsow, J.W., Rosenthal, A., Burton, L.E., Seid, D.P., Widmer, H.R., Nikolics, K. & Hefti, F. (1992) Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain. J. Neurosci., 12, 4391-4402.
    • (1992) J. Neurosci. , vol.12 , pp. 4391-4402
    • Knüsel, B.1    Winsow, J.W.2    Rosenthal, A.3    Burton, L.E.4    Seid, D.P.5    Widmer, H.R.6    Nikolics, K.7    Hefti, F.8
  • 33
    • 0028292913 scopus 로고
    • Regulated neurotrophin receptor responsiveness during neuronal migration and early differentiation
    • Knüsel, B., Rabin, S.J., Hefti, F. & Kaplan, D.R. (1994) Regulated neurotrophin receptor responsiveness during neuronal migration and early differentiation. J. Neurosci., 14, 1542-1554.
    • (1994) J. Neurosci. , vol.14 , pp. 1542-1554
    • Knüsel, B.1    Rabin, S.J.2    Hefti, F.3    Kaplan, D.R.4
  • 34
    • 0026054653 scopus 로고
    • Differential regulation of the low affinity nerve growth factor receptor during postnatal development of the rat brain
    • Koh, S. & Higgins, G.A. (1991) Differential regulation of the low affinity nerve growth factor receptor during postnatal development of the rat brain. J. Comp. Neurol., 313, 494-508.
    • (1991) J. Comp. Neurol. , vol.313 , pp. 494-508
    • Koh, S.1    Higgins, G.A.2
  • 35
    • 0022972782 scopus 로고
    • The role of nerve growth factor in the cns
    • Korsching, S. (1986) The role of nerve growth factor in the CNS. Trends Neurosci., 9, 570-573.
    • (1986) Trends Neurosci. , vol.9 , pp. 570-573
    • Korsching, S.1
  • 36
    • 0028920679 scopus 로고
    • Regulation of trka and chat expression in developing rat basal forebrain: Evidence that both exogenous and endogenous ngf regulate differentiation of cholinergic neurons
    • Li, Y., Holtzman, D.M., Kromer, L.F., Kaplan, D.R., Chua-Couzens, J., Clary, D.O., Knüsel, B. & Mobley, W. (1995) Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons. J. Neurosci., 15, 2888-2905.
    • (1995) J. Neurosci. , vol.15 , pp. 2888-2905
    • Li, Y.1    Holtzman, D.M.2    Kromer, L.F.3    Kaplan, D.R.4    Chua-Couzens, J.5    Clary, D.O.6    Knüsel, B.7    Mobley, W.8
  • 37
    • 0028123267 scopus 로고
    • Fibroblast growth factor-5 promotes differentiation of cultured rat septal cholinergic and raphe dopaminergic neurons: Comparison with the effects of neurotrophins
    • Lindholm, D., Hartikka, J., Berzaghi, M., Castren, E., Tzimapiorgis, G., Hughes, R.A. & Thoenen, H. (1994) Fibroblast growth factor-5 promotes differentiation of cultured rat septal cholinergic and raphe dopaminergic neurons: comparison with the effects of neurotrophins. Eur. J. Neurosci., 6, 244-252.
    • (1994) Eur. J. Neurosci. , vol.6 , pp. 244-252
    • Lindholm, D.1    Hartikka, J.2    Berzaghi, M.3    Castren, E.4    Tzimapiorgis, G.5    Hughes, R.A.6    Thoenen, H.7
  • 39
    • 0026469134 scopus 로고
    • Molecular cloning of rat trkc and distribution of cells expressing messenger rnas for members of the trk family in the rat central nervous system
    • Merlio, J.-P., Ernfors, P., Jaber, M. & Persson, H. (1992) Molecular cloning of rat TrkC and distribution of cells expressing messenger RNAs for members of the Trk family in the rat central nervous system. Neuroscience, 51, 513-532.
    • (1992) Neuroscience , vol.51 , pp. 513-532
    • Merlio, J.-P.1    Ernfors, P.2    Jaber, M.3    Persson, H.4
  • 40
    • 0026025820 scopus 로고
    • Trkb, a neural receptor protein-tyrosine kinase: Evidence for a full-length and two truncated receptors
    • Middlemas, D.S., Lindberg, R.A. & Hunter, T. (1991) TrkB, a neural receptor protein-tyrosine kinase: Evidence for a full-length and two truncated receptors. Mol. Cell. Biol., 11, 143-153.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 143-153
    • Middlemas, D.S.1    Lindberg, R.A.2    Hunter, T.3
  • 41
    • 0030935214 scopus 로고    scopus 로고
    • A critical period in the sensitivity of bf cholinergic neurons to ngf deprivation
    • Molnar, M., Ruberti, F., Cozzari, C., Domenici, L. & Cattaneo, A. (1997) A critical period in the sensitivity of BF cholinergic neurons to NGF deprivation. NeuroReport, 8, 575-579.
    • (1997) Neuroreport , vol.8 , pp. 575-579
    • Molnar, M.1    Ruberti, F.2    Cozzari, C.3    Domenici, L.4    Cattaneo, A.5
  • 44
    • 0026764458 scopus 로고
    • Detailed distribution of nerve growth factor in rat brain determined by a highly sensitive enzyme immunoassy
    • Nishio, T., Akiguchi, I. & Furokawa, S. (1992) Detailed distribution of nerve growth factor in rat brain determined by a highly sensitive enzyme immunoassy. Exp. Neurol., 16, 76-84.
    • (1992) Exp. Neurol. , vol.16 , pp. 76-84
    • Nishio, T.1    Akiguchi, I.2    Furokawa, S.3
  • 46
    • 0027502622 scopus 로고
    • Expression of members of the trk family in the developing postnatal rat brain
    • Ringsted, T., Lagercrantz, H. & Persson, H. (1993) Expression of members of the Trk family in the developing postnatal rat brain. Dev. Brain Res., 72, 119-131.
    • (1993) Dev. Brain Res. , vol.72 , pp. 119-131
    • Ringsted, T.1    Lagercrantz, H.2    Persson, H.3
  • 47
    • 0027717587 scopus 로고
    • Cloning and expression of an anti ngf antibody for studies using the neuroantibody approach
    • Ruberti, F., Bradbury, A. & Cattaneo, A. (1993) Cloning and expression of an anti NGF antibody for studies using the neuroantibody approach. Cell. Mol. Neurobiol., 13, 559-568.
    • (1993) Cell. Mol. Neurobiol. , vol.13 , pp. 559-568
    • Ruberti, F.1    Bradbury, A.2    Cattaneo, A.3
  • 48
    • 0029747240 scopus 로고    scopus 로고
    • Comparative study of brain-derived neurotrophic factor messenger rna and protein at the cellular level suggests multiple roles in hippocampus, striatum and cortex
    • Schmidt-Kastner, R., Wetmore, C. & Olson, L. (1996) Comparative study of brain-derived neurotrophic factor messenger RNA and protein at the cellular level suggests multiple roles in hippocampus, striatum and cortex. Neuroscience, 74, 161-183.
    • (1996) Neuroscience , vol.74 , pp. 161-183
    • Schmidt-Kastner, R.1    Wetmore, C.2    Olson, L.3
  • 49
    • 0021257975 scopus 로고
    • Specific retrograde transport of nerve growth factor (ngf) from neocortex to nucleus basalis in the rat
    • Sieler, M. & Schwab, M.E. (1984) Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat. Brain Res., 300, 33-39.
    • (1984) Brain Res. , vol.300 , pp. 33-39
    • Sieler, M.1    Schwab, M.E.2
  • 50
    • 0028331599 scopus 로고
    • Severe sensory and sympathetic neuropathies in mice carrying a disrupted trk/ngf receptor gene
    • Smeyne, R.J., Klein, R., Schnapp, A., Long, L.K., Bryant, S., Lewin, A., Lira, S.A. & Barbacid, M. (1994) Severe sensory and sympathetic neuropathies in mice carrying a disrupted trk/NGF receptor gene. Nature, 368, 246-249.
    • (1994) Nature , vol.368 , pp. 246-249
    • Smeyne, R.J.1    Klein, R.2    Schnapp, A.3    Long, L.K.4    Bryant, S.5    Lewin, A.6    Lira, S.A.7    Barbacid, M.8
  • 51
    • 0025061139 scopus 로고
    • Basal forebrain cell loss after fimbria-fornix transection
    • Tuszynski, M.E., Armstrong, D.M. & Gage, F.H. (1990) Basal forebrain cell loss after fimbria-fornix transection. Brain Res., 508, 241-248.
    • (1990) Brain Res. , vol.508 , pp. 241-248
    • Tuszynski, M.E.1    Armstrong, D.M.2    Gage, F.H.3
  • 52
    • 0027937360 scopus 로고
    • Ultrastructural and morphometric features of the acetylcholine innervation in adult rat parietal cortex: An electron microscopic study in serial section
    • Umbriaco, D., Watkiss, W.C., Descarries, L., Cozzari, C. & Hartman, B.K. (1994) Ultrastructural and morphometric features of the acetylcholine innervation in adult rat parietal cortex: An electron microscopic study in serial section. J. Comp. Neurol., 348, 351-373.
    • (1994) J. Comp. Neurol. , vol.348 , pp. 351-373
    • Umbriaco, D.1    Watkiss, W.C.2    Descarries, L.3    Cozzari, C.4    Hartman, B.K.5
  • 53
    • 0028878437 scopus 로고
    • Ngf deprivation of adult rat brain results in cholinergic hypofunction and selective impairments in spatial learning
    • Van der Zee, E.E.M.C., Lorenseen, S., Stanisz, J. & Diamond, J. (1995) NGF deprivation of adult rat brain results in cholinergic hypofunction and selective impairments in spatial learning. Eur. J. Neurosci., 7, 160-168.
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 160-168
    • Van Der Zee, E.E.M.C.1    Lorenseen, S.2    Stanisz, J.3    Diamond, J.4
  • 54
    • 0024730559 scopus 로고
    • Evidence for a physiological role of nerve growth factor in the central nervous system of neonatal rats
    • Vantini, G., Schiavo, N., Di Martino, A., Polaro, P., Triban, C., Callegaro, L., Toffano, G. & Leon, A. (1989) Evidence for a physiological role of nerve growth factor in the central nervous system of neonatal rats. Neuron, 3, 267-273.
    • (1989) Neuron , vol.3 , pp. 267-273
    • Vantini, G.1    Schiavo, N.2    Di Martino, A.3    Polaro, P.4    Triban, C.5    Callegaro, L.6    Toffano, G.7    Leon, A.8
  • 55
    • 0028286955 scopus 로고
    • Expression of neurotrophin and trk receptor genes in adult rats with fimbria transection: Effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration
    • Venero, J.L., Knüsel, B., Beck, K.D. & Hefti, F. (1994) Expression of neurotrophin and trk receptor genes in adult rats with fimbria transection: effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration. Neuroscience, 59, 797-815.
    • (1994) Neuroscience , vol.59 , pp. 797-815
    • Venero, J.L.1    Knüsel, B.2    Beck, K.D.3    Hefti, F.4
  • 56
    • 0027537224 scopus 로고
    • Bdnf protection of basal forebrain cholinergic neurons after axotomy: Complete protection of p75ngfr-positive cells
    • Widmer, R., Knüsel, B. & Hefti, F. (1993) BDNF protection of basal forebrain cholinergic neurons after axotomy: Complete protection of p75NGFR-positive cells. NeuroReport, 59, 363-366.
    • (1993) Neuroreport , vol.59 , pp. 363-366
    • Widmer, R.1    Knüsel, B.2    Hefti, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.