-
1
-
-
49449109965
-
-
http://www.clinicaltrials.gov/ct/action/GetStudy
-
-
-
-
2
-
-
0001359591
-
Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans
-
Napoli C, Lemieux C, Jorgensen R: Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell 1990;2:279-289.
-
(1990)
Plant Cell
, vol.2
, pp. 279-289
-
-
Napoli, C.1
Lemieux, C.2
Jorgensen, R.3
-
3
-
-
0036358853
-
RNAi (nematodes. Ceanorhabditis elegans)
-
Grishok A, Mello CC: RNAi (nematodes. Ceanorhabditis elegans). Adv Genet 2002;46:339-360.
-
(2002)
Adv Genet
, vol.46
, pp. 339-360
-
-
Grishok, A.1
Mello, C.C.2
-
4
-
-
0035942736
-
Duplexes of 21-nt RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T: Duplexes of 21-nt RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-498.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
5
-
-
0033572660
-
Targeted mRNA degradation by double-stranded RNA in vitro
-
Tuschl T, Zamore PD, Lehmann R, Bartel DP, Sharp PA: Targeted mRNA degradation by double-stranded RNA in vitro. Genes Dev 1999;13:3191-3197.
-
(1999)
Genes Dev
, vol.13
, pp. 3191-3197
-
-
Tuschl, T.1
Zamore, P.D.2
Lehmann, R.3
Bartel, D.P.4
Sharp, P.A.5
-
6
-
-
0036385852
-
Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo
-
Bertrand JR, Pottier M, Vekris A, Opolon P, Maksimenko A, Malvy C: Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo. Biochem Biophys Res Commun 2002;296:1000-1004.
-
(2002)
Biochem Biophys Res Commun
, vol.296
, pp. 1000-1004
-
-
Bertrand, J.R.1
Pottier, M.2
Vekris, A.3
Opolon, P.4
Maksimenko, A.5
Malvy, C.6
-
7
-
-
31544456413
-
Insights of the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging
-
Bartlett DW, Davis ME: Insights of the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging. Nucleic Acids Res 2005;34:322-333.
-
(2005)
Nucleic Acids Res
, vol.34
, pp. 322-333
-
-
Bartlett, D.W.1
Davis, M.E.2
-
8
-
-
0037447334
-
The microRNAs of Caenorhabditis elegans
-
Lim LP, Lau NP, Weinstein EG, Abdelhakim A, Yekta S, Rhoades MW, Burge CB, Bartel DP: The microRNAs of Caenorhabditis elegans. Genes Dev 2003;17:991-1008.
-
(2003)
Genes Dev
, vol.17
, pp. 991-1008
-
-
Lim, L.P.1
Lau, N.P.2
Weinstein, E.G.3
Abdelhakim, A.4
Yekta, S.5
Rhoades, M.W.6
Burge, C.B.7
Bartel, D.P.8
-
10
-
-
14544298301
-
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
-
Schiffelers RM, Ansari A, Xu J, Zhou Q, Tang Q, Storm G, Molema G, Lu PY, Scaria PV, Woodle MC: Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res 2004;32:e149.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Schiffelers, R.M.1
Ansari, A.2
Xu, J.3
Zhou, Q.4
Tang, Q.5
Storm, G.6
Molema, G.7
Lu, P.Y.8
Scaria, P.V.9
Woodle, M.C.10
-
11
-
-
23844474160
-
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
-
Song E, Zhu P, Lee SK, Chowdhury D, Kussman S, Dykxshoorn D, Feng Y, Palliser D, Weiner DB, Shankar P, Marasco WA, Lieberman J: Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol 2005;23:709-717.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 709-717
-
-
Song, E.1
Zhu, P.2
Lee, S.K.3
Chowdhury, D.4
Kussman, S.5
Dykxshoorn, D.6
Feng, Y.7
Palliser, D.8
Weiner, D.B.9
Shankar, P.10
Marasco, W.A.11
Lieberman, J.12
-
12
-
-
33746871416
-
Can siRNA technology provide the tools for gene therapy of the future?
-
Racz Z, Hamar P: Can siRNA technology provide the tools for gene therapy of the future? Curr Med Chem 2006;13:2299-2230.
-
(2006)
Curr Med Chem
, vol.13
, pp. 2299-2230
-
-
Racz, Z.1
Hamar, P.2
-
13
-
-
0037348329
-
RNA interference targeting Fas protects mice from fulminant hepatitis
-
Song E, Lee SK, Wang J, Ince N, Ouyang N, Min J, Chen J, Shankar P, Lieberman J: RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 2003;9:356-358.
-
(2003)
Nat Med
, vol.9
, pp. 356-358
-
-
Song, E.1
Lee, S.K.2
Wang, J.3
Ince, N.4
Ouyang, N.5
Min, J.6
Chen, J.7
Shankar, P.8
Lieberman, J.9
-
14
-
-
6944238701
-
Small interfering RNA targeting Fas protects mice from renal ischemia-reperfusion injury
-
Hamar P, Song E, Kökény G, Chen A, Ouyang N, Lieberman J: Small interfering RNA targeting Fas protects mice from renal ischemia-reperfusion injury. PNAS 2004;101:14883-14888.
-
(2004)
PNAS
, vol.101
, pp. 14883-14888
-
-
Hamar, P.1
Song, E.2
Kökény, G.3
Chen, A.4
Ouyang, N.5
Lieberman, J.6
-
15
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
Jackson AL, Bartz SR, Schelter J, Kobayshi SV, Burchard J, Mao M, Li B, Caret G, Linsey PS: Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 2003;21:635-637.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 635-637
-
-
Jackson, A.L.1
Bartz, S.R.2
Schelter, J.3
Kobayshi, S.V.4
Burchard, J.5
Mao, M.6
Li, B.7
Caret, G.8
Linsey, P.S.9
-
16
-
-
0038121109
-
Specificity of short interfering RNA determined through gene expression signatures
-
Semizarov D, Frost L, Sparthy A, Kroeger P, Halbert DN, Fesik SW: Specificity of short interfering RNA determined through gene expression signatures. PNAS 2003;100:6347-6352.
-
(2003)
PNAS
, vol.100
, pp. 6347-6352
-
-
Semizarov, D.1
Frost, L.2
Sparthy, A.3
Kroeger, P.4
Halbert, D.N.5
Fesik, S.W.6
-
17
-
-
0042972933
-
Activation of the interferon system by short-interfering RNAs
-
Sledz CA, Holko M, de Veer MJ, Silverman RH, Williams BRG: Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 2003;5:834-839.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 834-839
-
-
Sledz, C.A.1
Holko, M.2
de Veer, M.J.3
Silverman, R.H.4
Williams, B.R.G.5
-
18
-
-
22344454846
-
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRN A
-
Judge AD, Sood V, Shaw JR, Fang D, McClintock K, MacLachlan I: Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRN A. Nat Biotechnol 2005;23:457-462.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 457-462
-
-
Judge, A.D.1
Sood, V.2
Shaw, J.R.3
Fang, D.4
McClintock, K.5
MacLachlan, I.6
-
19
-
-
0025314311
-
Discrimination between activators and nonactivators of the alternative pathway of the complement regultion via a sialic acid/polyanion binding site on factor H
-
Meri S, Pangburn MK: Discrimination between activators and nonactivators of the alternative pathway of the complement regultion via a sialic acid/polyanion binding site on factor H. PNAS USA 1990;87:3982-3986.
-
(1990)
PNAS USA
, vol.87
, pp. 3982-3986
-
-
Meri, S.1
Pangburn, M.K.2
-
20
-
-
0030922755
-
Activation of the Alternative Pathway of Complement by a Phosphorothioate Oligonucleotide: Potential Mechanism of Action
-
Henry SP, Giclas PC, Leeds J, Pangburn M, Auletta C, Levin AA, Kornbrust DJ: Activation of the Alternative Pathway of Complement by a Phosphorothioate Oligonucleotide: Potential Mechanism of Action. Pharmacology 1997;281:810-816.
-
(1997)
Pharmacology
, vol.281
, pp. 810-816
-
-
Henry, S.P.1
Giclas, P.C.2
Leeds, J.3
Pangburn, M.4
Auletta, C.5
Levin, A.A.6
Kornbrust, D.J.7
-
21
-
-
0036848796
-
Pharmacokinetics, toxicity, and efficacy of ends-modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic liposome
-
Gokhale PC, Zhang C, Newsome JT, Pei J, Ahmad I, Rahman A, Dritschilo A, Kasid UN: Pharmacokinetics, toxicity, and efficacy of ends-modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic liposome. Clin Cancer Res 2002;8:3611-3621.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3611-3621
-
-
Gokhale, P.C.1
Zhang, C.2
Newsome, J.T.3
Pei, J.4
Ahmad, I.5
Rahman, A.6
Dritschilo, A.7
Kasid, U.N.8
-
22
-
-
34347272315
-
Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA
-
Heidel JD, Yu Z, Liu JYC, Rele SM, Liang Y, Zeidan RK, Kornbrust DJ, Davis ME: Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA. PNAS 2007;104:5715-5721.
-
(2007)
PNAS
, vol.104
, pp. 5715-5721
-
-
Heidel, J.D.1
Yu, Z.2
Liu, J.Y.C.3
Rele, S.M.4
Liang, Y.5
Zeidan, R.K.6
Kornbrust, D.J.7
Davis, M.E.8
-
23
-
-
35148845281
-
Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway
-
John M, Constien R, Akinc A, Goldberg M, Moon YA, Spranger M, Hadwiger P, Soutschek J, Vornlocher HP, Manoharan M, Stoffel M, Langer R, Anderson DG, Horton JD, Koteliansky V, Bumcrot D: Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway. Nature Lett 2007;449:745-748.
-
(2007)
Nature Lett
, vol.449
, pp. 745-748
-
-
John, M.1
Constien, R.2
Akinc, A.3
Goldberg, M.4
Moon, Y.A.5
Spranger, M.6
Hadwiger, P.7
Soutschek, J.8
Vornlocher, H.P.9
Manoharan, M.10
Stoffel, M.11
Langer, R.12
Anderson, D.G.13
Horton, J.D.14
Koteliansky, V.15
Bumcrot, D.16
-
24
-
-
33745299723
-
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
-
Grimm D, Streetz KL, Jopling CL, Storm TA, Pandey K, Davis CR, Marion P, Salazar F, Kay MA: Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 2006;441:537-541.
-
(2006)
Nature
, vol.441
, pp. 537-541
-
-
Grimm, D.1
Streetz, K.L.2
Jopling, C.L.3
Storm, T.A.4
Pandey, K.5
Davis, C.R.6
Marion, P.7
Salazar, F.8
Kay, M.A.9
-
25
-
-
33845399708
-
Effect of adenovirusmediated RNA interference on endogenous miRNAs in a mouse model of multidrog resistance protein 2 gene silencing
-
Narvaiza I, Aparicio O, Vera M, Razquin N, Bortolanza S, Prieto J, Fortes P: Effect of adenovirusmediated RNA interference on endogenous miRNAs in a mouse model of multidrog resistance protein 2 gene silencing. J Virol 2006;80:12236-12247.
-
(2006)
J Virol
, vol.80
, pp. 12236-12247
-
-
Narvaiza, I.1
Aparicio, O.2
Vera, M.3
Razquin, N.4
Bortolanza, S.5
Prieto, J.6
Fortes, P.7
-
26
-
-
34548818764
-
-
Zhang S, Zhao B, Jiang H, Wang B, Ma B: Cationic lipids and polymers mediated vectors for delivery of siRNA. J Control Release 2007;123:1-10
-
Zhang S, Zhao B, Jiang H, Wang B, Ma B: Cationic lipids and polymers mediated vectors for delivery of siRNA. J Control Release 2007;123:1-10.
-
-
-
-
27
-
-
33645550066
-
RNAi a novel antisense technology and its therapeutical potentail
-
Dallas A, Vlassov AV: RNAi a novel antisense technology and its therapeutical potentail. Med Sci Monit 2006;12:RA67-RA74.
-
(2006)
Med Sci Monit
, vol.12
-
-
Dallas, A.1
Vlassov, A.V.2
-
28
-
-
33748510411
-
Increasing resistance of tubular epithelial cells to apoptosis by shRNA therapy ameliorates ischaemia-reperfusion injury
-
Du C, Wang S, Diao H, Guan Q, Zhong R, Jevnikar AM: Increasing resistance of tubular epithelial cells to apoptosis by shRNA therapy ameliorates ischaemia-reperfusion injury. Am J Transplant 2006;6:2256-2267.
-
(2006)
Am J Transplant
, vol.6
, pp. 2256-2267
-
-
Du, C.1
Wang, S.2
Diao, H.3
Guan, Q.4
Zhong, R.5
Jevnikar, A.M.6
-
29
-
-
0038610713
-
Caspase 8 small interfering RNA prevents acute liver failure in mice
-
Zender L, Hütker S, Liedtke C, Tillmann HL, Zender S, Mundt B, Walthemathe M, Gösling T, Flemming P, Malek NP, Trautwein C, Manns MP, Kühnel P, Kubicka S: Caspase 8 small interfering RNA prevents acute liver failure in mice. PNAS USA 2003;100:7797-7802.
-
(2003)
PNAS USA
, vol.100
, pp. 7797-7802
-
-
Zender, L.1
Hütker, S.2
Liedtke, C.3
Tillmann, H.L.4
Zender, S.5
Mundt, B.6
Walthemathe, M.7
Gösling, T.8
Flemming, P.9
Malek, N.P.10
Trautwein, C.11
Manns, M.P.12
Kühnel, P.13
Kubicka, S.14
-
30
-
-
0037107396
-
Signaling pathways and late-onset gene induction associated with renal mesangial cell hypertrophy
-
Goruppi S, Bonventre JV, Kyriakis JM: Signaling pathways and late-onset gene induction associated with renal mesangial cell hypertrophy. EMBO J 2002;21:5427-5436.
-
(2002)
EMBO J
, vol.21
, pp. 5427-5436
-
-
Goruppi, S.1
Bonventre, J.V.2
Kyriakis, J.M.3
|