Differential mechanisms of nitric oxide- and peroxynitrite-induced cell death

Molecular Pharmacology

Volumn 66, Issue 4, 2004, Pages 1043-1053

  Meij, Johanna T A ^a   Haselton, Carole L ^b   Hillman, Kristin L ^b   Muralikrishnan, Dhanasekaran ^b,c   Ebadi, Manuchair ^b   Yu, Lei ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 3 AMINOBENZAMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE 3; CASPASE INHIBITOR; CYCLIC GMP; DIETHYLENETRIAMINE; DNA FRAGMENT; INSULIN; LINSIDOMINE; METIROSINE; N BENZYLOXYCARBONYLVALYLALANYL(ASPARTYL BETA METHYL ESTER) FLUOROMETHYLKETONE; NITRIC OXIDE; NITRITE; PEROXYNITRITE; PROTEIN KINASE B; SOMATOMEDIN C; SPERMINE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DISSOCIATION; DOSE TIME EFFECT RELATION; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INCUBATION TIME; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; CELL DEATH; CELL SURVIVAL; HUMANS; HYBRIDOMAS; MICE; NITRIC OXIDE; NITRIC OXIDE DONORS; PEROXYNITROUS ACID; RATS; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 4844229079     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.104.001354     Document Type: Article

References (40)

1. Aarts M, Liu Y, Liu L, Besshoh S, Arundine M, Gurd JW, Wang YT, Salter MW, and Tymianski M (2002) Treatment of ischemic brain damage by perturbing NMDA receptor - PSD-95 protein interactions. Science (Wash DC) 298:846-850.
2. Almeida A and Bolanos JP (2001) A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons. J Neurochem 77:676-690.
3. Banasiak KJ, Xia Y, and Haddad GG (2000) Mechanisms underlying hypoxia-induced neuronal apoptosis. Prog Neurobiol 62:215-249.
4. Brookes PS and Darley-Usmar VM (2004) Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition. Am J Physiol 286:H39-H46.
5. Brookes PS, Levonen AL, Shiva S, Sarti P, and Darley-Usmar VM (2002) Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species. Free Radic Biol Med 33:755-764.
6. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, and Reed JC (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science (Wash DC) 282:1318-1321.
7. Clementi E, Brown GC, Feelisch M, and Moncada S (1998) Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc Natl Acad Sci USA 95:7631-7636.
8. d'Ischia M and Costantini C (1995) Nitric oxide-induced nitration of catecholamine neurotransmitters: a key to neuronal degeneration? Bioorg Med Chem 3:923-927.
9. Datta SR, Brunet A, and Greenberg ME (1999) Cellular survival: a play in three Akts. Genes Dev 13:2905-2927.
10. Espey MG, Xavier S, Thomas DD, Miranda KM, and Wink DA (2002) Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms. Proc Natl Acad Sci USA 99:3481-3486.
11. Facchinetti F, Sasaki M, Cutting FB, Zhai P, Macdonald JE, Reif D, Beal MF, Huang PL, Dawson TM, Gurney ME, et al. (1999) Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis. Neuroscience 90:1483-1492.
12. Feelisch M (1998) The use of nitric oxide donors in pharmacological studies. Naunyn Schmiedeberg's Arch Pharmacol 358:113-122.
13. Garcia-Nogales P, Almeida A, and Bolanos JP (2003) Peroxynitrite protects neurons against nitric oxide-mediated apoptosis. A key role for glucose-6-phosphate dehydrogenase activity in neuroprotection. J Biol Chem 278:864-874.
14. Gratton JP, Morales-Ruiz M, Kureishi Y, Fulton D, Walsh K, and Sessa WC (2001) Akt down-regulation of P38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. J Biol Chem 276:30359-30365.
15. 2-dependent mechanism resulting in the formation of nitrate ions. Biochem J 362:459-464.
16. Haddad IY, Crow JP, Hu P, Ye Y, Beckman J, and Matalon S (1994) Concurrent generation of nitric oxide and superoxide damages surfactant protein A. Am J Physiol 267:L242-L249.
17. Heales SJ, Bolanos JP, Stewart VC, Brookes PS, Land JM, and Clark JB (1999) Nitric oxide, mitochondria and neurological disease. Biochim Biophys Acta 1410: 215-228.
18. Horn TFW, Wolf G, Duffy S, Weiss S, Keilhoff G, and Macvicar BA (2002) Nitric oxide promotes intracellular calcium release from mitochondria in striatal neurons. FASEB J 16:1611-1622.
19. Ischiropoulos H, Duran D, and Horwitz J (1995) Peroxynitrite-mediated inhibition of DOPA synthesis in PC12 cells. J Neurochem 65:2366-2372.
20. Itzhak Y, Martin JL, and Ali SF (2000) Comparison between the role of the neuronal and inducible nitric oxide synthase in methamphetamine-induced neurotoxicity and sensitization. Ann NY Acad Sci 914:104-111.
21. Keefer LK, Nims RW, Davies KM, and Wink DA (1996) "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. Methods Enzymol 268:281-293.
22. Kordower JH, Emborg ME, Bloch J, Ma SY, Chu Y, Leventhal L, McBride J, Chen EY, Palfi S, Roitberg BZ, et al. (2000) Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science (Wash DC) 290:767-773.
23. Kreklau EL, Carlson EJ, and Drewett JG (1999) Nitric oxide inhibits human aldosteronogenesis without guanylyl cyclase stimulation. Mol Cell Endocrinol 153: 103-111.
24. Mabley JG, Southan GJ, Salzman AL, and Szabo C (2004) The combined inducible nitric oxide synthase inhibitor and free radical scavenger guanidinoethyldisulfide prevents multiple low-dose streptozotocin-induced diabetes in vivo and interleukin-1beta-induced suppression of islet insulin secretion in vitro. Pancreas 28:E39-E44.
25. Mandir AS, Przedborski S, Jackson-Lewis V, Wang ZQ, Simbulan-Rosenthal CM, Smulson ME, Hoffman BE, Guastella DB, Dawson VL, and Dawson TM (1999) Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Proc Natl Acad Sci USA 96: 5774-5779.
26. Mannick JB, Hausladen A, Liu L, Hess DT, Zeng M, Miao QX, Kane LS, Gow AJ, and Stamler JS (1999) Fas-induced caspase denitrosylation. Science (Wash DC) 284: 651-654.
27. Offen D, Beart PM, Cheung NS, Pascoe CJ, Hochman A, Gorodin S, Melamed E, Bernard R, and Bernard O (1998) Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity. Proc Natl Acad Sci USA 95:5789-5794.
28. Pfeiffer S and Mayer B (1998) Lack of tyrosine nitration by peroxynitrite generated at physiological pH. J Biol Chem 273:27280-27285.
29. Pfeiffer S, Schmidt K, and Mayer B (2000) Dityrosine formation outcompetes tyrosine nitration at low steady-state concentrations of peroxynitrite. Implications for tyrosine modification by nitric oxide/superoxide in vivo. J Biol Chem 275:6346-6352.
30. Przedborski S, Jackson-Lewis V, Yokoyama R, Shibata T, Dawson VL, and Dawson TM (1996) Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proc Natl Acad Sci USA 93:4565-4571.
31. Przedborski S, Kostic V, Jackson-Lewis V, Naini AB, Simonetti S, Fahn S, Carlson E, Epstein CJ, and Cadet JL (1992) Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced neurotoxicity. J Neurosci 12:1658-1667.
32. Samdani AF, Dawson TM, and Dawson VL (1997) Nitric oxide synthase in models of focal ischemia. Stroke 28:1283-1288.
33. Schmidt K, Desch W, Klatt P, Kukovetz WR, and Mayer B (1998) Release of NO from donor compounds: a mathematical model for calculation of NO concentrations in the presence of oxygen. Methods Mol Biol 100:281-289.
34. Schrammel A, Pfeiffer S, Schmidt K, Koesling D, and Mayer B (1998) Activation of soluble guanylyl cyclase by the nitrovasodilator 3-morpholinosydnonimine involves formation of S-nitrosoglutathione. Mol Pharmacol 54:207-212.
35. Stamler JS, Lamas S, and Fang FC (2001) Nitrosylation: the prototypic redox-based signaling mechanism. Cell 106:675-683.
36. Tian B, Liu J, Bitterman PB, and Bache RJ (2002) Mechanisms of cytokine induced NO-mediated cardiac fibroblast apoptosis. Am J Physiol 283:H1958-H1967.
37. Torreilles F, Salman-Tabcheh S, Guerin M, and Torreilles J (1999) Neurodegenerative disorders: the role of peroxynitrite. Brain Res Brain Res Rev 30:153-163.
38. Trackey JL, Uliasz TF, and Hewett SJ (2001) SIN-1-induced cytotoxicity in mixed cortical cell culture: peroxynitrite-dependent and -independent induction of excitotoxic cell death. J Neurochem 79:445-455.
39. Weisleder N, Taffet GE, and Capetanaki Y (2004) Bcl-2 overexpression corrects mitochondrial defects and ameliorates inherited desmin null cardiomyopathy. Proc Natl Acad Sci USA 101:769-774.
40. Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H, and Przedborski S (2002) Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 22:1763-1771.