The role of toxicology to characterize biomarkers for agrochemicals with potential endocrine activities

Reproductive Toxicology

Volumn 26, Issue 1, 2008, Pages 1-7

  Mantovani, Alberto ^a   Maranghi, Francesca ^a   La Rocca, Cinzia ^a   Tiboni, Gian Mario ^b   Clementi, Maurizio ^c  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c Clinical and Epidemiological Genetics   (Italy)

Author keywords

Children; Exposure; Food safety; Interaction; Pregnancy; Risk assessment; Susceptibility; Toxicogenomics

Indexed keywords

AGRICULTURAL CHEMICAL; BIOLOGICAL MARKER; CYTOCHROME P450; DICARBOXIMIDE; ENDOCRINE DISRUPTOR; ETHYLENE BIS DITHIOCARBAMATE; HORMONE; MOLECULAR MARKER; PESTICIDE; TRIAZOLE DERIVATIVE;

ARTICLE; BIOLOGICAL MONITORING; ENDOCRINE FUNCTION; ENVIRONMENTAL EXPOSURE; GENETIC POLYMORPHISM; HAZARD ASSESSMENT; HEALTH HAZARD; HORMONE DETERMINATION; HUMAN; NUTRITIONAL STATUS; OCCUPATIONAL EXPOSURE; PREDICTION; PREGNANCY; REPRODUCTION; RISK ASSESSMENT; SPERM; TOXICOLOGY;

AGROCHEMICALS; ANIMALS; BIOLOGICAL MARKERS; ENDOCRINE DISRUPTORS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; HUMANS; RISK ASSESSMENT;

ANIMALIA;

EID: 48349141798     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2008.05.063     Document Type: Article

References (82)

1. Curl C.L., Fenske R.A., Kissel J.C., Shirai J.H., Moate T.F., Griffith W., et al. Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children. Environ Health Perspect 110 (2002) A787-A792
2. Petrelli G., Figà-Talamanca I., Lauria L., and Mantovani A. Spontaneous abortion in spouses of greenhouse workers exposed to pesticides. Environ Health Prev Med 8 (2003) 77-81
3. Rescia M, Mantovani A, Pesticides as endocrine disrupters: identification of hazards for female reproductive function. In: Nicolopoulou-Stamati P, Hens L, Howard CV, editors. Reproductive health and the environment. vol. 22. Series: Environmental Science and Technology Library, Springer, Dordrecht (NL), p. 161-86.
4. Clementi M., Causin R., Marzocchi C., Mantovani A., and Tenconi R. A study of the impact of agricultural pesticide use on the prevalence of birth defects in northeast Italy. Reprod Toxicol 24 1 (2007) 1-8
5. European Food Safety Authority. Opinion of the Scientific Panel on contaminants in the food chain on a request from the commission related to camphechlor as undesirable substance in animal feed. http://www.efsa.europa.eu/en/science/contam/contam_opinions/803.html; 2005a.
6. European Food Safety Authority. Opinion of the Scientific Panel on contaminants in the food chain related to endosulfan as undesirable substance in animal feed. http://www.efsa.europa.eu/en/science/contam/contam_opinions/1025.html; 2005b.
7. Neubert D. Vulnerability of the endocrine system to xenobiotic influence. Regul Toxicol Pharmacol 26 (1997) 9-29
8. Mantovani A. Hazard identification and risk assessment of endocrine disrupting chemicals with regard to developmental effects. Toxicology 181/182 (2002) 367-370
9. Calamandrei G., Maranghi F., Venerosi A., Alleva E., and Mantovani A. Efficient testing strategies for evaluation of xenobiotics with neuroendocrine activity. Reprod Toxicol 22 (2006) 164-174
10. Nakanishi T., Nishikawa J., and Tanaka K. Molecular targets of organotin compounds in endocrine disruption: do organotin compounds function as aromatase inhibitors in mammals?. Environ Sci 13 2 (2006) 89-100
11. Mantovani A., and Macrì A. Endocrine effects in the hazard assessment of drugs used in animal production. J Exp Clin Cancer Res 21 (2002) 445-456
12. Harvey P.W., and Johnson I. Approaches to the assessment of toxicity data with endpoints related to endocrine disruption. J Appl Toxicol 22 (2002) 241-247
13. Mantovani A. Risk assessment of endocrine disrupters. The role of toxicological studies. Ann NY Acad Sci 1076 (2006) 239-252
14. Hulka B.S. Overview of biological markers. Biological markers in epidemiology vol. 1190 (1990), Oxford University Press, New York 3-15
15. Eskenazi B., Mocarelli P., Warner M., Samuels S., Needham L., Patterson D., et al. Seveso Women's Health Study: does zone of residence predict individual TCDD exposure?. Chemosphere 43 4-7 (2001) 937-942
16. Arbuckle T.E., Burnett R., Cole D., Teschke K., Dosemeci M., Bancej C., et al. Predictors of herbicide exposure in farm applicators. Int Arch Occup Environ Health 75 6 (2002) 406-414
17. Angerer J., Ewers U., and Wilhelm M. Human biomonitoring: state of the art. Int J Hyg Environ Health 210 3/4 (2007) 201-228
18. European Commission. Monitoring of pesticide residues in products of plant origin in the European Union, Norway, Iceland and Liechtenstein. 2005 Report; 2007.
19. Jensen A.F., Petersen A., and Granby K. Cumulative risk assessment of the intake of organophosphorus and carbamate pesticides in the Danish diet. Food Addit Contamin 20 (2003) 776-785
20. Fenske R.A., Kedan G., Lu C., Fisker-Andersen J.A., and Curl C.L. Assessment of organophosphorous pesticide exposures in the diets of preschool children in Washington State. J Expo Anal Environ Epidemiol 12 (2002) 21-28
21. Whyatt R.M., Camann D., Perera F.P., Rauh V.A., Tang D., Kinney P.L., et al. Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth. Toxicol Appl Pharmacol 206 (2005) 246-254
22. International Programme on Chemical Safety. Biomarkers and risk assessment: concepts and principles. Environmental Health Criteria, 155. World Health Organization, Geneva; 1993.
23. Aprea C., Colosio C., Mammone T., Minoia C., and Maroni M. Biological monitoring of pesticide exposure: a review of analytical methods. J Chromatogr B Anal Technol Biomed Life Sci 769 (2002) 191-219
24. Colosio C., Visentin S., Birindelli S., Campo L., Fustinoni S., Mariani F., et al. Reference values for ethylenethiourea in urine in Northern Italy: results of a pilot study. Toxicol Lett 162 (2006) 153-157
25. Ohyama K., Maki S., Sato K., and Kato Y. Comparative in vitro metabolism of methoxychlor in male and female rats: metabolism of demethylated methoxychlor metabolites by precision-cut rat liver slices. Xenobiotica 35 7 (2005) 683-695
26. Timchalk C., Kousba A.A., and Poet T.S. An age-dependent physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus insecticide chlorpyrifos in the preweanling rat. Toxicol Sci 98 2 (2007) 348-365
27. Turci R., Barisano A., Balducci C., Colosio C., and Minoia C. Determination of dichloroanilines in human urine by gas chromatography/mass spectrometry: validation protocol and establishment of Reference Values in a population group living in central Italy. Rapid Commun Mass Spectrom 20 17 (2006) 2621-2625
28. Ostrea Jr. E.M., Bielawski D.M., Posecion Jr. N.C., Corrion M., Villanueva-Uy E., Jin Y., et al. A comparison of infant hair, cord blood and meconium analysis to detect fetal exposure to environmental pesticides. Environ Res 106 2 (2008) 277-283
29. Lu C., Anderson L.C., Morgan M.S., and Fenske R.A. Salivary concentrations of atrazine reflect free atrazine plasma levels in rats. J Toxicol Environ Health A 53 4 (1998) 283-292
30. Ozkaynak H., Whyatt R.M., Needham L.L., Akland G., and Quackenboss J. Exposure assessment implications for the design and implementation of the National Children's Study. Environ Health Perspect 113 8 (2005) 1108-1115
31. Tsatsakis A.M., Tzatzarakis M.N., and Tutudaki M. Pesticide levels in head hair samples of Cretan population as an indicator of present and past exposure. Forensic Sci Int 176 1 (2007) 67-71
32. Posecion N., Ostrea E., Bielawski D., Corrion M., Seagraves J., and Jin Y. Detection of exposure to environmental pesticides during pregnancy by the analysis of maternal hair using GC-MS. Chromatographia 64 11/12 (2006) 681-687
33. Younglai E.V., Foster W.G., Hughes E.G., Trim K., and Jarrell J.F. Levels of environmental contaminants in human follicular fluid, serum, and seminal plasma of couples undergoing in vitro fertilization. Arch Environ Contam Toxicol 43 1 (2002) 121-126
34. De Felip E., di Domenico A., Miniero R., and Silvestroni L. Polychlorobiphenyls and other organochlorine compounds in human follicular fluid. Chemosphere 54 (2004) 1445-1449
35. Fernández M.F., Rivas A., Olea-Serrano F., Cerrillo I., Molina-Molina J.M., Araque P., et al. Assessment of total effective xenoestrogen burden in adipose tissue and identification of chemicals responsible for the combined estrogenic effect. Anal Bioanal Chem 379 1 (2004) 163-170
36. Long M., Deutch B., and Bonefeld-Jorgensen E.C. AhR transcriptional activity in serum of Inuits across Greenlandic districts. Environ Health 6 (2007) 32
37. Bonefeld-Jorgensen E.C., Hjelmborg P.S., Reinert T.S., Andersen B.S., Lesovoy V., Lindh C.H., Hagmar L., Giwercman A., Erlandsen M., Manicardi G.C., Spano M., Toft G., and Bonde J.P. Xenoestrogenic activity in blood of European and Inuit populations. Environ Health 5 (2006) 5-12
38. Toft G., Long M., Krüger T., Hjelmborg P.S., Bonde J.P., Rignell-Hydbom A., et al. Semen quality in relation to xenohormone and dioxin-like serum activity among Inuits and three European populations. Environ Health Perspect 115 Suppl. 1 (2007) 15-20
39. Levy G., Lutz I., Krüger A., von Tümpling W., and Kloas W. Retinol-binding protein as a biomarker to assess endocrine-disrupting compounds in the environment. Anal Bioanal Chem 378 3 (2004) 676-683
40. Nandi D., Patra R.C., and Swarup D. Oxidative stress indices and plasma biochemical parameters during oral exposure to arsenic in rats. Food Chem Toxicol 44 9 (2006) 1579-1584
41. Frazzoli C., Dragone R., Mantovani A., Massimi C., and Campanella L. Functional toxicity and tolerance patterns of bioavailable Pd(II), Pt(II), and Rh(III) on suspended Saccharomyces cerevisiae cells assayed in tandem by a respirometric biosensor. Anal Bioanal Chem 389 7/8 (2007) 2185-2194
42. Gonzales-Reyes S., Martinez L., Martinez-Calonge W., Fernandez-Dumont V., and Tovar J.A. Effects of nitrofen and vitamins A, C and E on maturation of cultured human H441 pneumocytes. Biol Neonate 90 1 (2006) 9-16
43. Teimouri F., Amirkabirian N., Esmaily H., Mohammadirad A., Aliahmadi A., and Abdollahi M. Alteration of hepatic cells glucose metabolism as a non-cholinergic detoxication mechanism in counteracting diazinon-induced oxidative stress. Hum Exp Toxicol 25 12 (2006) 697-703
44. Cravedi J.P., Zalko D., Savouret J.F., Menuet A., and Jégou B. The concept of endocrine disruption and human health. Med Sci (Paris) 23 2 (2007) 198-204
45. Bradlow H.L., Davis D.L., Lin G., Sepkovic D., and Tiwari R. Effects of pesticides on the ratio of 16 alpha/2-hydroxyestrone: a biologic marker of breast cancer risk. Environ Health Perspect 103 Suppl. 7 (1995) 147-150
46. Goetz A.K., Ren H., Schmid J.E., Blystone C.R., Thillainadarajah I., Best D.S., et al. Disruption of testosterone homeostasis as a mode of action for the reproductive toxicity of triazole fungicides in the male rat. Toxicol Sci 95 1 (2007) 227-239
47. Gray Jr. L.E., Wolf C., Lambright C., Mann P., Price M., Cooper R.L., et al. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol Ind Health 15 1/2 (1999) 94-118
48. Tully D.B., Bao W., Goetz A.K., Blystone C.R., Ren H., Schmid J.E., et al. Gene expression profiling in liver and testis of rats to characterize the toxicity of triazole fungicides. Toxicol Appl Pharmacol 215 3 (2006) 260-273
49. Maranghi F., Macri C., Ricciardi C., Stazi A.V., Rescia M., and Mantovani A. Histological and histomorphometric alterations in thyroid and adrenals of CD rat pups exposed in utero to methyl thiophanate. Reprod Toxicol 17 5 (2003) 617-623
50. Jeong S.H., Kim B.Y., Kang H.G., Ku H.O., and Cho J.H. Effect of chlorpyrifos-methyl on steroid and thyroid hormones in rat F0- and F1-generations. Toxicology 220 2/3 (2006) 189-202
51. Meeker J.D., Barr D.B., and Hauser R. Thyroid hormones in relation to urinary metabolites of non-persistent insecticides in men of reproductive age. Reprod Toxicol 22 3 (2006) 437-442
52. Swan S.H., Kruse R.L., Liu F., Barr D.B., Drobnis E.Z., Redmon J.B., et al. Study for Future Families Research Group. Semen quality in relation to biomarkers of pesticide exposure. Environ Health Perspect 111 (2003) 1478-1484
53. Traina M.E., Rescia M., Urbani E., Mantovani A., Macrì C., Ricciardi C., et al. Long-lasting effects of lindane on mouse spermatogenesis induced by in utero exposure. Reproduct Toxicol 17 (2003) 25-35
54. Rockett J.C., and Kim S.J. Biomarkers of reproductive toxicity. Cancer Biomark 1 1 (2005) 93-108
55. Long M., Stronati A., Bizzaro D., Kruger T., Manicardi G.C., Hjelmborg P.S., et al. Relation between serum xenobiotic-induced receptor activities and sperm DNA damage and sperm apoptotic markers in European and Inuit populations. Reproduction 133 (2007) 517-530
56. Elzanaty S., Rignell-Hydbom A., Jonsson B.A., Pedersen H.S., Ludwicki J.K., Shevets M., et al. INUENDO. Association between exposure to persistent organohalogen pollutants and epididymal and accessory sex gland function: multicentre study in Inuit and European populations. Reproduct Toxicol 22 (2006) 765-773
57. Sallmen M., Liesivuori J., Taskinen H., Lindbohm M.L., Anttila A., Aalto L., et al. Time to pregnancy among the wives of Finnish greenhouse workers. Scand J Work Environ Health 29 (2003) 85-93
58. Meeker J.D., Ryan L., Barr D.B., and Hauser R. Exposure to nonpersistent insecticides and male reproductive hormones. Epidemiology 17 1 (2006) 61-68
59. Meeker J.D., Ryan L., Barr D.B., Herrick R.F., Bennett D.H., Bravo R., et al. The relationship of urinary metabolites of carbaryl/naphthalene and chlorpyrifos with human semen quality. Environ Health Perspect 112 17 (2004) 1665-1670
60. Laws S.C., Ferrell J.M., Stoker T.E., Schmid J., and Cooper R.L. The effects of atrazine on female wistar rats: an evaluation of the protocol for assessing pubertal development and thyroid function. Toxicol Sci 58 2 (2000) 366-376
61. Cecconi S., Paro R., Rossi G., and Macchiarelli G. The effects of the endocrine disruptors dithiocarbamates on the mammalian ovary with particular regard to mancozeb. Curr Pharm Des 13 29 (2007) 2989-3004
62. Manzo L., Artigas F., Martínez E., Mutti A., Bergamaschi E., Nicotera P., et al. Biochemical markers of neurotoxicity. A review of mechanistic studies and applications. Hum Exp Toxicol 15 Suppl. 1 (1996) S20-S35
63. Smialowicz R.J. The rat as a model in developmental immunotoxicology. Hum Exp Toxicol 21 9/10 (2002) 513-519
64. Baken K.A., Arkusz J., Pennings J.L., Vandebriel R.J., and van Loveren H. In vitro immunotoxicity of bis(tri-n-butyltin)oxide (TBTO) studied by toxicogenomics. Toxicology 237 1-3 (2007) 35-48
65. Anway M.D., Cupp A.S., Uzumcu M., and Skinner M.K. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science 308 5727 (2005) 1466-1469
66. Ergene S., Celik A., Cavaş T., and Kaya F. Genotoxic biomonitoring study of population residing in pesticide contaminated regions in Göksu Delta: micronucleus, chromosomal aberrations and sister chromatid exchanges. Environ Int 33 7 (2007) 877-885
67. Martin M.T., Brennan R.J., Hu W., Ayanoglu E., Lau C., Ren H., et al. Toxicogenomic study of triazole fungicides and perfluoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanisms of toxicity. Toxicol Sci 97 2 (2007) 595-613
68. Barrier M., and Mirkes P.E. Proteomics in developmental toxicology. Reprod Toxicol 19 3 (2005) 291-304
69. van Ravenzwaay B., Cunha G.C., Leibold E., Looser R., Mellert W., Prokoudine A., et al. The use of metabolomics for the discovery of new biomarkers of effect. Toxicol Lett 172 1/2 (2007) 21-28
70. Heijne W.H., Kienhuis A.S., van Ommen B., Stierum R.H., and Groten J.P. Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology. Exp Rev Proteomics 2 5 (2005) 767-780
71. Bearer C.F. The special and unique vulnerability of children to environmental hazards. Neurotoxicology 21 6 (2000) 925-934
72. Leung F.Y., Bradley C., and Pellar T.G. Reference intervals for blood lead and evaluation of zinc protoporphyrin as a screening test for lead toxicity. Clin Biochem 26 6 (1993) 491-496
73. Eaton D.L. Biotransformation enzyme polymorphism and pesticide susceptibility. Neurotoxicology 21 1/2 (2000) 101-111
74. Dai D., Tang J., Rose R., Hodgson E., Bienstock R.J., Mohrenweiser H.W., et al. Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. J Pharmacol Exp Ther 299 3 (2001) 825-831
75. Zhou Z.J., Zheng J., Wu Q.E., and Xie F. Carboxylic esterase and its associations with long-term effects of organophosphorus pesticides. Biomed Environ Sci 20 4 (2007) 284-290
76. Giwercman A., Rylander L., Rignell-Hydbom A., Jönsson B.A., Pedersen H.S., Ludwicki J.K., et al. Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics. Pharmacogenet Genom 17 6 (2007) 391-401
77. Crisi G.M., Tsai S.C., Haffty B.G., Phillips R.F., and Rimm D.L. Immunocytochemical analysis of breast cells obtained by ductal lavage. Cancer 96 4 (2002) 244-249
78. Zagrodzki P., Ratajczak R., and Wietecha-Posłuszny R. The interaction between selenium status, sex hormones, and thyroid metabolism in adolescent girls in the luteal phase of their menstrual cycle. Biol Trace Elem Res 120 1-3 (2007) 51-60
79. Baldi F., and Mantovani A. A new database for food safety: EDID (Endocrine disrupting chemicals-Diet Interactions Database). Ann Ist Super Sanità 44 (2008) 57-62
80. Morgan K.T., Pino M., Crosby L.M., Wang M., Elston T.C., Jayyosi Z., et al. Complementary roles for toxicologic pathology and mathematics in toxicogenomics, with special reference to data interpretation and oscillatory dynamics. Toxicol Pathol 32 Suppl. 1 (2004) 13-25
81. Shibata K., Fukuwatari T., Iguchi Y., Kurata Y., Sudo M., and Sasaki R. Comparison of the effects of di(2-ethylhexyl)phthalate, a peroxisome proliferator, on the vitamin metabolism involved in the energy formation in rats fed with a casein or gluten diet. Biosci Biotechnol Biochem 70 6 (2006) 1331-1337
82. Smolders R., and Schoeters G. Identifying opportunities and gaps for establishing an integrated EDR-triad at a European level. Int J Hyg Environ Health 210 3/4 (2007) 253-257