Efficient testing strategies for evaluation of xenobiotics with neuroendocrine activity

Reproductive Toxicology

Volumn 22, Issue 2, 2006, Pages 164-174

  Calamandrei, Gemma ^a   Maranghi, Francesca ^a   Venerosi, Aldina ^a   Alleva, Enrico ^a   Mantovani, Alberto ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Aggressive behaviour; Endocrine disrupters; HHG axis; Parental behaviour; Reproductive behaviour; Rodents; Sexual differentiation of the brain; Sexual maturation; Social behaviour; Steroid hormones; Thyroid hormones

Indexed keywords

ENDOCRINE DISRUPTOR; STEROID HORMONE; THYROID HORMONE; XENOBIOTIC AGENT;

AGGRESSION; BEHAVIOR; BRAIN MATURATION; DEVELOPMENTAL STAGE; ENDOCRINE FUNCTION; HOMEOSTASIS; HORMONAL REGULATION; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; HYPOTHALAMUS HYPOPHYSIS THYROID SYSTEM; MATERNAL BEHAVIOR; NEUROENDOCRINE SYSTEM; NEUROTOXICITY; NONHUMAN; PARENTAL BEHAVIOR; REVIEW; RISK FACTOR; RODENT; SEX DIFFERENTIATION; SEXUAL BEHAVIOR; SEXUAL MATURATION; SOCIAL BEHAVIOR;

ANIMALS; BEHAVIOR, ANIMAL; ENDOCRINE DISRUPTORS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; SEX DIFFERENTIATION; TOXICITY TESTS; XENOBIOTICS;

RODENTIA;

EID: 33745600385     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2006.04.003     Document Type: Review

References (77)

1. Miller K.P., Borgeest C., Greenfeld C., Tomic D., and Flaws J.A. In utero effects of chemicals on reproductive tissues in females. Toxicol Appl Pharmacol 198 (2004) 111-131
2. Campbell B., Dickey J.T., and Swanson P. Endocrine changes during onset of puberty in male spring Chinook salmon, Oncorhynchus tshawytscha. Biol Reprod 69 (2003) 2109-2117
3. Weltzien F.A., Andersson E., Andersen O., Shalchian-Tabrizi K., and Norberg B. The brain-pituitary-gonad axis in male teleosts, with special emphasis on flatfish (Pleuronectiformes). Comp Biochem Physiol A Mol Integr Physiol 137 (2004) 447-477
4. Cooke P.S., Holsberger D.R., Witorsch R.J., Sylvester P.W., Meredith J.M., Treinen K.A., et al. Thyroid hormone, glucocorticoids, and prolactin at the nexus of physiology, reproduction, and toxicology. Toxicol Appl Pharmacol 194 (2004) 309-335
5. Porterfield S.P. Thyroidal dysfunction and environmental chemicals-potential impact on brain development. Environ Health Perspect 108 Suppl. 3 (2000) 433-438
6. Manthey D., and Behl C. From structural biochemistry to expression profiling: neuroprotective activities of estrogen. Neuroscience 138 (2006) 845-850
7. Gorski R.A., Gordon J.H., Shryne J.E., and Southam A.M. Evidence for a morphological sex difference within the medial preoptic area of the rat brain. Brain Res 148 (1978) 333-346
8. Davis E.C., Popper P., and Gorski R.A. The role of apoptosis in sexual differentiation of the rat sexually dimorphic nucleus of the preoptic area. Brain Res 734 (1996) 10-18
9. Simerly R.B. Wired on hormones: endocrine regulation of hypothalamic development. Curr Opin Neurobiol 15 (2005) 81-85
10. McEwen B.S., and Alves S.E. Estrogen actions in the central nervous system. Endocr Rev 20 (1999) 279-307
11. Bielsky I.F., and Young L.J. Oxytocin, vasopressin, and social recognition in mammals. Peptides 25 (2004) 1565-1574
12. Website Endocrine Disrupting Chemicals, Istituto Superiore di Sanità, http://www.iss.it/inte/.
13. Mantovani A. Hazard identification and risk assessment of endocrine disrupting chemicals with regard to developmental effects. Toxicology 181-182 (2002) 367-370
14. Jacobson J.I., and Jacobson S.W. Intellectual impairment in children exposed to polychlorinated biphenils in utero. N Engl J Med 335 (1996) 783-789
15. Ribas-Fito N., Sala M., Kogevinas M., and Sunyer J. Polychlorinated biphenyls (PCBs) and neurological development in children: a systematic review. J Epidemiol Community Health 55 (2001) 537-546
16. Stewart P., Reihman J., Gump B., Lonky E., Darvill T., and Pagano J. Response inhibition at 8 and 9 1/2 years of age in children prenatally exposed to PCBs. Neurotoxicol Teratol 27 (2005) 771-780
17. Tilson H.A. Developmental neurotoxicology of endocrine disruptors and pesticides: identification of information gaps and research needs. Environ Health Perspect 106 Suppl. 3 (1998) 807-811
18. Petroff B.K., Roby K.F., Gao X., Son D., Williams S., Johnson D., et al. A review of mechanisms controlling ovulation with implications for the anovulatory effects of polychlorinated dibenzo-p-dioxins in rodents. Toxicology 158 (2001) 91-107
19. Ushinohama K., Son D., Roby K.F., Rozman K.K., and Terranova P.F. Impaired ovulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in immature rats treated with equine chorionic gonadotropin. Reprod Toxicol 15 (2001) 275-280
20. Mably T.A., Moore R.W., Goy R.W., and Peterson R.E. In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 2. Effects on sexual behavior and the regulation of luteinizing hormone secretion in adulthood. Toxicol Appl Pharmacol 114 (1992) 108-117
21. Hays L.E., Carpenter C.D., and Petersen S.L. Evidence that GABAergic neurons in the preoptic area of the rat brain are targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin during development. Environ Health Perspect 110 Suppl. 3 (2002) 369-376
22. Cummings A.M., and Kavlock R.J. Function of sexual glands and mechanism of sex differentiation. J Toxicol Sci 29 (2004) 167-178
23. Valdez K.E., and Petroff B.K. Potential roles of the aryl hydrocarbon receptor in female reproductive senescence. Reprod Biol 4 (2004) 243-258
24. Kuriyama S., Fidalgo-Neto A., Mathar W., Palavinskas R., Friedrich K., and Chahoud I. Effect of low dose mono-ortho 2,3′,4,4′,5-pentachlorobiphenyl on thyroid hormone status and EROD activity in rat offspring: consequences for risk assessment. Toxicology 186 (2003) 11-20
25. Khan M.A., and Hansen L.G. Ortho-substituted polychlorinated biphenyl (PCB) congeners (95 or 101) decrease pituitary response to thyrotropin releasing hormone. Toxicol Lett 144 (2003) 173-182
26. Gore A.C., Wu T.J., Oung T., Lee J.B., and Woller M.J. A novel mechanism for endocrine-disrupting effects of polychlorinated biphenyls: direct effects on gonadotropin-releasing hormone neurones. J Neuroendocrinol 14 (2002) 814-823
27. Rayner J.L., Wood C., and Fenton S.E. Exposure parameters necessary for delayed puberty and mammary gland development in Long-Evans rats exposed in utero to atrazine. Toxicol Appl Pharmacol 195 (2004) 23-34
28. Friedmann A.S. Atrazine inhibition of testosterone production in rat males following peripubertal exposure. Reprod Toxicol 16 (2002) 275-279
29. Rayner J.L., Enoch R.R., and Fenton S.E. Adverse effects of prenatal exposure to atrazine during a critical period of mammary gland growth. Toxicol Sci 87 (2005) 255-266
30. Stoker T.E., Laws S.C., Guidici D.L., and Cooper R.L. The effects of atrazine on puberty in the male Wistar rats: an evaluation in the protocol for the assessment of pubertal development and thyroid function. Toxicol Sci 58 (2002) 50-59
31. Laws S.C., Ferrell J.M., Stoker T.E., Schmid J., and Cooper R.L. The effects of atrazine on female Wistar rats: an evaluation of the protocol for assessing pubertal development and thyroid function. Toxicol Sci 58 (2000) 366-376
32. Rooney A.A., Matulka R.A., and Luebke R.W. Developmental atrazine exposure suppresses immune function in male, but not female Sprague-Dawley rats. Toxicol Sci 76 (2003) 366-375
33. Ashby J., Tinwell H., Stevens J., Pastoor T., and Breckenridge C.B. The effects of atrazine on the sexual maturation of female rats. Regul Toxicol Pharmacol 35 (2002) 468-473
34. Narotsky M.G., Best D.S., Guidici D.L., and Cooper R.L. Strain comparisons of atrazine-induced pregnancy loss in the rat. Reprod Toxicol 15 (2001) 61-69
35. Cummings A.M., Rhodes B.E., and Cooper R.L. Effect of atrazine on implantation and early pregnancy in 4 strains of rats. Toxicol Sci 58 (2000) 135-143
36. Rodriguez V.M., Thiruchelvam M., and Cory Slechta D.A. Sustained exposure to the widely used herbicide atrazine: altered function and loss of neurons in brain monoamine systems. Environ Health Perspect 113 (2005) 708-715
37. Markey C.M., Luque E.H., Munoz De Toro M., Sonnenschein C., and Soto A.M. In utero exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland. Biol Reprod 65 (2001) 1215-1223
38. Patisaul H.B., Fortino A.E., and Polston E.K. Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV. Neurotoxicol Teratol 28 (2006) 111-118
39. Lafuente A., Marquez N., Perez-Lorenzo M., Pazo D., and Esquifino A.I. Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic-pituitary-testicular axis function in the rat. Food Chem Toxicol 38 (2000) 913-923
40. Tilton S.C., Foran C.M., and Benson W.H. Effects of cadmium on the reproductive axis of Japanese medaka (Oryzias latipes). Comp Biochem Physiol C Toxicol Pharmacol 136 (2003) 265-276
41. Svechnikov K., Supornsilchai V., Strand M.L., Wahlgren A., Seidlova-Wuttke D., Wuttke W., et al. Influence of long-term dietary administration of procymidone, a fungicide with anti-androgenic effects, or the phytoestrogen genistein to rats on the pituitary-gonadal axis and Leydig cell steroidogenesis. J Endocrinol 187 (2005) 117-124
42. Sarkar R., Mohanakumar K.P., and Chowdhury M. Effects of an organophosphate pesticide, quinalphos, on the hypothalamo-pituitary-gonadal axis in adult male rats. J Reprod Fertil 118 (2000) 29-38
43. Luo X., Ikeda Y., Lala D., Rice D., Wong M., and Parker K.L. Steroidogenic factor 1 (SF-1) is essential for endocrine development and function. J Steroid Biochem Mol Biol 69 (1999) 13-18
44. Kim H.S., Kim T.S., Shin J.H., Moon H.J., Kang I.H., Kim I.Y., et al. Neonatal exposure to di(n-butyl) phthalate (DBP) alters male reproductive-tract development. J Toxicol Environ Health A 67 (2004) 2045-2060
45. Nagai A., Ikeda Y., Aso T., Eto K., and Ikeda M.A. Exposure of neonatal rats to diethylstilbestrol affects the expression of genes involved in ovarian differentiation. J Med Dent Sci 50 (2003) 35-40
46. Handy R.D., Galloway T.S., and Depledge M.H. A proposal for the use of biomarkers for the assessment of chronic pollution and in regulatory toxicology. Ecotoxicology 12 (2003) 331-343
47. Laws S.C., Ferrell J.M., Stoker T.E., and Cooper R.L. Pubertal development in female Wistar rats following exposure to propazine and atrazine biotransformation by-products, diamino-S-chlorotriazine and hydroxyatrazine. Toxicol Sci 76 (2003) 190-200
48. Kunimatsu T., Yamada T., Miyata K., Yabushita S., Seki T., Okuno Y., et al. Evaluation for reliability and feasibility of the draft protocol for the enhanced rat 28-day subacute study (OECD Guideline 407) using androgen antagonist flutamide. Toxicology 200 (2004) 77-89
49. Besedovsky H.O., and del Rey A. Introduction: immune-neuroendocrine network. Front Horm Res 29 (2002) 1-14
50. Schulte A., Althoff J., Ewe S., Richter-Reichhelm H.B., and BGVV Group Investigators. Two immunotoxicity ring studies according to OECD TG 407-comparison of data on cyclosporin A and hexachlorobenzene. Regul Toxicol Pharmacol 36 (2002) 12-21
51. Wu J.M., Zelinski M.B., Ingram D.K., and Ottinger M.A. Ovarian aging and menopause: current theories, hypotheses and research models. Exp Biol Med (Maywood) 230 (2005) 818-828
52. Palanza P., Morellini F., Parmigiani S., and vom Saal F.S. Prenatal exposure to endocrine disrupting chemicals: effects on behavioral development. Neurosci Biobehav Rev 23 (1999) 1011-1027
53. Feder H.H. Hormones and sexual behavior. Annu Rev Psychol 35 (1984) 165-200
54. Beach F.A. Sexual attractivity, proceptivity, and receptivity in female mammals. Horm Behav 7 (1976) 105-138
55. Lee H.C., Yamanouchi K., and Nishihara M. Effects of perinatal exposure to phthalate/adipate esters on hypothalamic gene expression and sexual behavior in rats. J Reprod Dev (2006) [Epub ahead of print]
56. Moniz A.C., Cruz-Casallas P.E., Oliveira C.A., Lucisano A., Florio J.C., Nicolau A.A., et al. Perinatal fenvalerate exposure: behavioral and endocrinology changes in male rats. Neurotoxicol Teratol 21 (1999) 611-618
57. Moniz A.C., Cruz-Casallas P.E., Salzgeber S.A., Varoli F.M., Spinosa H.S., and Bernardi M.M. Behavioral and endocrine changes induced by perinatal fenvalerate exposure in female rats. Neurotoxicol Teratol 27 (2005) 609-614
58. Grant E.C., and Mackintosh J.H. A comparison of the social postures of some common laboratory rodents. Behaviour 21 (1963) 247-259
59. Bigi S., Maestripieri D., Aloe L., and Alleva E. NGF decreases isolation-induced aggressive behavior, while increasing adrenal volume, in adult male mice. Physiol Behav 51 (1992) 337-343
60. Alleva E. Assessment of aggressive behavior in rodents. In: Conn M.P. (Ed). Methods in Neuroscience. Paradigms for the study of behavior Vol. 14 (1993), Academic Press, New York 111-137
61. Wisniewski A.B., Cernetich A., Gearhart J.P., and Klein S.L. Perinatal exposure to genistein alters reproductive development and aggressive behavior in male mice. Physiol Behav 84 (2005) 327-334
62. Svare B. Maternal aggression in the mice: influence of the young. Biobehav Rev 1 (1977) 151-164
63. Svare B., and Gandelman R. Postpartum aggression in mice: experiential and environmental factors. Horm Behav 4 (1973) 323-334
64. Lonstein J.S., and Gammie S.C. Sensory, hormonal, and neural control of maternal aggression in laboratory rodents. Neurosci Biobehav Rev 26 (2002) 869-888
65. Laviola G., Bignami G., and Alleva E. Interacting effects of oxazepam in late pregnancy and fostering procedure on mouse maternal behavior. Neurosci Biobehav Rev 15 4 (1991) 501-504
66. Numan M. Maternal behavior. In: Knobil K.N., and Neil J. (Eds). The physiology of reproduction (1988), Raven Press, New York 1529-1645
67. Calamandrei G., and Keverne E.B. Differential expression of Fos protein in the brain of female mice dependent on pup sensory cues and maternal experience. Behav Neurosci 108 (1994) 113-120
68. Simmons S.L., Cummings J.A., Clemens L.G., and Nunez A.A. Exposure to PCB 77 affects the maternal behavior of rats. Physiol Behav 84 1 (2005) 81-86
69. Palanza P., Morellini F., Parmigiani S., and vom Saal F.S. Ethological methods to study the effects of maternal exposure to estrogenic endocrine disrupters: a study with methoxychlor. Neurotoxicol Teratol 24 (2002) 55-69
70. Andersen S.L. Trajectories of brain development: point of vulnerability or window of opportunity?. Neurosci Biobehav Rev 27 (2003) 3-18
71. Terranova M.L., Laviola G., and Alleva E. Ontogeny of amicable social behavior in the mouse: gender differences and ongoing isolation outcomes. Dev Psychobiol 26 (1993) 467-481
72. Meaney M.J., and Stewart J. Neonatal-androgens influence the social play of prepubescent rats. Horm Behav 15 (1981) 197-213
73. Calamandrei G., Venerosi A., Branchi I., Chiarotti F., Verdina A., Bucci F., et al. Effects of prenatal AZT on mouse neurobehavioral development and passive avoidance learning. Neurotoxicol Teratol 21 1 (1999) 29-40
74. Ricceri L., Markina N., Valanzano A., Fortuna S., Cometa M.F., Meneguz A., et al. Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice. Toxicol Appl Pharmacol 191 (2003) 189-201
75. Porrini S., Belloni V., Della Seta D., Farabollini F., Giannelli G., and Dessi-Fulgheri F. Early exposure to a low dose of bisphenol A affects socio-sexual behavior of juvenile female rats. Brain Res Bull 65 (2005) 261-266
76. McCarthy M.M., and Konkle A.T. When is a sex difference not a sex difference?. Front Neuroendocrinol 26 (2005) 85-102
77. Aardema M.J., and MacGregor J.T. Toxicology and genetic toxicology in the new era of "toxicogenomics": impact of "-omics" technologies. Mutat Res 499 (2002) 13-25