Anthrax lethal toxin suppresses chemokine production in human neutrophil NB-4 cells

Biochemical and Biophysical Research Communications

Volumn 374, Issue 2, 2008, Pages 288-293

  Barson, Helen V ^a   Mollenkopf, Hans ^b   Kaufmann, Stefan H E ^b   Rijpkema, Sjoerd ^a  

^a NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^b MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

Author keywords

Anthrax; Biomarkers; CCL20; Chemokines; Interleukin 8; Neutrophils

Indexed keywords

ANTHRAX TOXIN; CHEMOATTRACTANT; CHEMOKINE; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MESSENGER RNA; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; TOXIN ANTIBODY; TRANSCRIPTION FACTOR;

ARTICLE; BACILLUS ANTHRACIS; CELL ASSAY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOSUPPRESSIVE TREATMENT; LETHAL GENE; MICROARRAY ANALYSIS; NEUTROPHIL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE;

ANTIGENS, BACTERIAL; BACTERIAL TOXINS; CELL LINE; CHEMOKINES; GENE EXPRESSION; HUMANS; IMMUNE TOLERANCE; NEUTROPHILS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; TRANSCRIPTION FACTORS;

BACILLUS ANTHRACIS;

EID: 48349127068     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.07.018     Document Type: Article

References (40)

1. Turk B.E. Manipulation of host signalling pathways by anthrax toxins. Biochem. J. 42 (2007) 405-417
2. Comer J.E., Galindo C.L., Chopra A.K., and Peterson J.W. GeneChip analyses of global transcriptional responses of murine macrophages to the lethal toxin of Bacillus anthracis. Infect. Immun. 73 (2005) 1879-1885
3. Sapra R., Gaucher S.P., Lachmann J.S., Buffleben G.M., Chirica G.S., Comer J.E., Peterson J.W., Chopra A.K., and Singh A.K. Proteomic analyses of murine macrophages treated with Bacillus anthracis lethal toxin. Microb. Pathog. 41 (2006) 157-167
4. Erwin J.L., DaSilva L.M., Bavari S., Little S.F., Friedlander A.M., and Chanh T.C. Macrophage-derived cell lines do not express proinflammatory cytokines after exposure to Bacillus anthracis lethal toxin. Infect. Immun. 69 (2001) 1175-1177
5. Cote C.K., Van Rooijen N., and Welkos S.L. Roles of macrophages and neutrophils in the early host response to Bacillus anthracis spores in a mouse model of infection. Infect. Immun. 74 (2006) 469-480
6. Friedlander A.M. Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process. J. Biol. Chem. 261 (1986) 7123-7126
7. Staats H.F., Alam S.M., Scearce R.M., Kirwan S.M., Zhang J.X., Gwinn W.M., and Haynes B.F. In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunity. Infect. Immun. 75 (2007) 5443-5452
8. Smith J.A. Neutrophils, host defense, and inflammation: a double-edged sword. J. Leukoc. Biol. 56 (1994) 672-686
9. Mayer-Scholl A., Hurwitz R., Brinkmann V., Schmid M., Jungblut P., Weinrauch Y., and Zychlinsky A. Human neutrophils kill Bacillus anthracis. Cell. Microbiol. 1 (2005) 179-186
10. During R.L., Li W., Hao B., Koenig J.M., Stephens D.S., Quinn C.P., and Southwick F.S. Anthrax lethal toxin paralyzes neutrophil actin-based motility. J. Infect. Dis. 192 (2005) 837-845
11. During R.L., Gibson B.G., Li W., Bishai E.A., Sidhu G.S., Landry J., and Southwick F.S. Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation. EMBO J. 26 (2007) 2240-2250
12. Grinberg L.M., Abramova F.A., Yampolskaya O.V., Walker D.H., and Smith J.H. Quantitative pathology of inhalational anthrax 1: quantitative microscopic findings. Mod. Pathol. 14 (2001) 482-495
13. Fleck R.A., Athwal H., Bygraves J.A., Hockley D.J., Feavers I.M., and Stacey G.N. Optimization of nb-4 and hl-60 differentiation for use in opsonophagocytosis assays. In Vitro Cell Dev. Biol. Anim. 39 (2003) 235-242
14. Prior S., Fleck R.A., Gillett M.L., Rigsby P.R., Corbel M.J., Stacey G.N., and Xing D.K.L. Evaluation of adenyl cyclase toxin constructs from Bordetella pertussis as candidate vaccine components in an in vitro model of complement-dependent intraphagocytic killing. Vaccine 24 (2006) 4794-4803
15. Wheeler J.X., Whiting G., and Rijpkema S. Proteomic analysis of the response of the human neutrophil-like cell line NB-4 after exposure to anthrax lethal toxin. Proteomics Clin. Appl. 1 (2007) 1266-1279
16. Rossi-Paccani S., Tonello F., Ghittoni R., Natale M., Muraro L., D'Elios M.M., Tang W., Montecucco C., and Baldari C.T. Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signalling. J. Exp. Med. 201 (2005) 325-331
17. + T cells. J. Immunol. 174 (2005) 4966-4971
18. Churchill G.A. Fundamentals of experimental design for cDNA microarrays. Nat. Genet. 32 (2002) 490-495 Suppl
19. -ΔΔCt method. Methods 25 (2001) 402-408
20. Albrecht M.T., Li H., Williamson E.D., LeButt C.S., Flick-Smith H.C., Quinn C.P., Westra H., Galloway D., Mateczun A., Goldman S., Groen H., and Baillie L.W.J. Human monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthrax. Infect. Immun. 75 (2007) 5425-5433
21. Hoffmann E., Ashouri J., Wolter S., Doerrie A., Breiholz O., Schneider H., Wagner E.F., Troppmair J., Mackman N., and Kracht M. Transcriptional regulation of EGR-1 by the IL-1-Jnk-MKK7-c-Jun pathway. J. Biol. Chem. 283 (2008) 12120-12128
22. Cho S.J., Kang M.J., Homer R.J., Kang H.R., Zhang X., Lee P.J., Elias J.A., and Lee C.G. Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodelling. J. Biol. Chem. 281 (2006) 8161-8168
23. Liebermann D.A., Gregory B., and Hoffman B. AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis. Int. J. Oncol. 12 (1998) 685-700
24. Dang C.V., Resar L.M.S., Emison E., Kim S., Li Q., Prescott J.E., Wonsey D., and Zeller K. Function of the c-myc oncogenic transcription factor. Exp. Cell Res. 253 (1999) 63-77
25. Yamamoto M., Yamazaki S., Uematsu S., Sato S., Hemmi H., Hoshino K., Kaisho T., Kuwata H., Takeuchi O., Takeshige K., Saitoh T., Yamaoka S., Yamamoto N., Yamamoto S., Muta T., Takeda K., and Akira S. Regulation of Toll/IL-1-receptor mediated gene expression by the inducible nuclear factor IκBζ. Nature 430 (2004) 218-222
26. Pei L., Castrillo A., and Tontonoz P. Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77. Mol. Endocrinol. 20 (2006) 786-794
27. Kuhn J.F., Hoerth P., Hoehn S.T., Preckel T., and Tomer K.B. Proteomics study of anthrax lethal toxin-treated murine macrophages. Electrophoresis 27 (2006) 1584-1597
28. Tracey K.J., and Cerami A. Tumour necrosis factor: a pleiotropic cytokine and therapeutic target. Annu. Rev. Med. 45 (1994) 491-503
29. Rollins B.J. Chemokines. Blood 90 (1997) 909-928
30. Riedel D.D., and Kaufmann S.H.E. Chemokine secretion by human polymorphonuclear granulocytes after stimulation with Mycobacterium tuberculosis and lipoarabinomannan. Infect. Immun. 65 (1997) 4620-4623
31. Hachicha M., Rathanaswami P., Naccache P.H., and McColl S.R. Regulation of chemokine gene expression in human peripheral blood neutrophils phagocytosing microbial pathogens. J. Immunol. 160 (1998) 449-454
32. Marie C., Roman-Roman S., and Rawaldi G. Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Infect. Immun. 67 (1999) 688-693
33. Mukaida N. Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases. Am. J. Physiol. Lung Cell. Mol. Physiol. 284 (2003) L566-L577
34. Scapini P., Laudanna C., Pinardi C., Allavena P., Mantovani A., Sozzani S., and Cassatella M.A. Neutrophils produce biologically active macrophage inflammatory protein-3α (MIP-3α)/CCL20 and MIP-3β/CCL19. Eur. J. Immunol. 31 (2001) 1981-1988
35. Akahoshi T., Sasahara T., Namai R., Matsui T., Watabe H., Kitasato H., Inoue M., and Kondo H. Production of macrophage inflammatory protein 3α (MIP-3α) (CCL20) and MIP-3β (CCL19) by human peripheral blood neutrophils in response to microbial pathogens. Infect. Immun. 71 (2003) 524-526
36. Bennouna S., Bliss S.K., Curiel T.J., and Denkers E.Y. Cross-talk in the innate immune system: neutrophils instruct recruitment and activation of dendritic cells during microbial infection. J. Immunol. 171 (2003) 6052-6058
37. Schutyser E., Struyf S., and Van Damme J. The CC chemokine CCL20 and its receptor CCR6. Cytokine Growth Factor Rev. 14 (2003) 409-426
38. Polenghi A., Bossi F., Fischetti F., Durigutto P., Cabrelle A., Tamassia N., Cassatella M.A., Montecucco C., Tedesco F., and De Bernard M. The neutrophil-activating protein of Helicobacter pylori crosses endothelia to promote neutrophil adhesion in vivo. J. Immunol. 178 (2007) 1312-1320
39. Batty S., Chow E.M.C., Kassam A., Der S.D., and Mogridge J. Inhibition of mitogen-activated protein kinase signalling by Bacillus anthracis lethal toxin causes destabilization of interleukin-8 mRNA. Cell. Microbiol. 8 (2006) 130-138
40. Park J.M., Ng V.H., Maeda S., Rest R.F., and Karin M. Anthrolysin O and other Gram-positive cytolysins are Toll-like receptor 4 agonists. J. Exp. Med. 200 (2004) 1647-1655