Macrophage-derived cell lines do not express proinflammatory cytokines after exposure to Bacillus anthracis lethal toxin

Infection and Immunity

Volumn 69, Issue 2, 2001, Pages 1175-1177

  Erwin, J L ^a   Dasilva, L M ^a   Bavari, S ^a   Little, S F ^a   Friedlander, A M ^a   Chanh, T C ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CYTOKINE; INTERLEUKIN 1BETA; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTHRAX; ARTICLE; BACILLUS ANTHRACIS; CELL LINE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNE RESPONSE; MACROPHAGE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RNA TRANSCRIPTION;

ANIMALS; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; CELL LINE; CYTOKINES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; RNA, MESSENGER;

EID: 0035142005     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.2.1175-1177.2001     Document Type: Article

References (7)

1. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
2. New insights into the control of MAP kinase pathways
3. Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process
4. Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin
5. Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFN gamma-induced release of NO and TNFalpha
6. Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-α) translation: Glucocorticoids inhibit TNF-α translation by blocking JNK/SAPK
7. Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages