Metformin treatment restores the altered microvascular reactivity in neonatal streptozotocin-induced diabetic rats increasing NOS activity, but not NOS expression

Life Sciences

Volumn 77, Issue 21, 2005, Pages 2676-2689

  Sartoretto, Juliano Luiz ^a   Melo, Gessilda A N ^b   Carvalho, Maria H C ^a   Nigro, Dorothy ^a   Passaglia, Rita T ^a   Scavone, Cristóforo ^a   Cuman, Roberto K N ^b   Fortes, Zuleica B ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

Diabetes mellitus; Metformin; Microvascular reactivity; Nitric oxide synthase

Indexed keywords

ARGININE; CITRULLINE; COMPLEMENTARY DNA; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; METFORMIN; NEURONAL NITRIC OXIDE SYNTHASE; STREPTOZOCIN; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; BLOOD VESSEL DIAMETER; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; IMPAIRED GLUCOSE TOLERANCE; INFLAMMATION; MESENTERIC ARTERY; MESENTERY; MICROSCOPY; MICROVASCULATURE; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOZOCIN DIABETES; VASODILATATION; VENULE;

ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; CAPILLARIES; DIABETES MELLITUS, EXPERIMENTAL; EATING; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; MALE; METFORMIN; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPLANCHNIC CIRCULATION; VASODILATOR AGENTS;

RATTUS NORVEGICUS;

EID: 24344454347     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.05.022     Document Type: Article

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