The safety of metformin in heart failure

Annals of Pharmacotherapy

Volumn 41, Issue 4, 2007, Pages 642-646

  Roberts, Felicia ^a   Ryan, Gina J ^a  

^a MERCER UNIVERSITY   (United States)

Author keywords

Heart failure; Lactic acidosis; Metformin

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; CREATININE; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; INSULIN; LACTIC ACID; METFORMIN; SULFONYLUREA;

ARTICLE; CLINICAL TRIAL; DIABETES MELLITUS; DRUG CONTRAINDICATION; DRUG SAFETY; HEART FAILURE; HUMAN; INSULIN RESISTANCE; LACTATE BLOOD LEVEL; LACTIC ACIDOSIS; MAJOR CLINICAL STUDY; PATIENT MONITORING; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK REDUCTION;

ACIDOSIS, LACTIC; AGED; CLINICAL TRIALS; FEMALE; HEALTH STATUS; HEART FAILURE, CONGESTIVE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; METFORMIN;

EID: 34247253225     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1H523     Document Type: Article

References (23)

1. Hunt SA, Abraham WT, Chin MH, et al. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to update the 2001 guidelines for the evaluation and management of heart failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation 2005;112:e154-235. DOI 10.1161/CIRCULATIONAHA.105.167586
2. Ingelsson E, Sundstrom J, Arnlov J, Zethelius B, Lind L. Insulin resistance and risk of congestive heart failure. JAMA 2005;294:334-41. DOI 10.1001/jama.294.3.334
3. Nichols GA, Gullion CM, Koro CE, Ephross SA, Brown JB. The incidence of congestive heart failure in type 2 diabetes: an update. Diabetes Care 2004;27:1879-84.
4. Package insert. Glucophage (metformin). Princeton, NJ: Bristol-Myers Squibb Company, March 2004.
5. Eurich DT, Majumdar SR, McAlister FA, Tsuyuki RT, Johnson JA. Improved clinical outcomes associated with metformin in patients with diabetes and heart failure. Diabetes Care 2005;28:2345-51.
6. Inzucchi SE. Metformin and heart failure: innocent until proven guilty. Diabetes Care 2005;28:2585-7.
7. Masoudi FA, Inzucchi SE, Wang Y, Havranek EP, Foody JM, Krumholz HM. Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study. Circulation 2005;111: 583-90. DOI 10.1161/01.CIR.0000154542.13412.B1
8. UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998;352:854-65. DOI 10.1016/S0140-6736%2898%2907037-8
9. Hulisz DT, Bonfiglio MF, Murray RD. Metformin-associated lactic acidosis. J Am Board Fam Pract 1998;11:233-6.
10. Lalau JD, Race JM. Lactic acidosis in metformin therapy. Drugs 1999; 58(Suppl 1):55-60; discussion 75-82.
11. Lalau JD, Race JM. Metformin and lactic acidosis in diabetic humans. Diabetes Obes Metab 2000;2:131-7. DOI:10.1046/j.1463-1326.2000.00053.x
12. Lalau JD, Race JM. Lactic acidosis in metformin therapy: searching for a link with metformin in reports of 'metformin-associated lactic acidosis'. Diabetes Obes Metab 2001;3:195-201. DOI:10.1046/j.1463-1326.2001.00128.x
13. Salpeter S, Greyber E, Pasternak G, Salpeter E. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2003:CD002967. DOI:10.1001/archinte.163.21.2594
14. Holstein A, Nahrwold D, Hinze S, Egberts EH. Contra-indications to metformin therapy are largely disregarded. Diabet Med 1999;16:692-6. DOI 10.1046/j.1464-5491.1999.00115.x
15. Calabrese AT, Coley KC, DaPos SV, Swanson D, Rao RH. Evaluation of prescribing practices: risk of lactic acidosis with metformin therapy. Arch Intern Med 2002;162:434-7. DOI:10.1001/archinte.162.4.434
16. Jones GC, Macklin JP, Alexander WD. Contraindications to the use of metformin. BMJ 2003;326:4-5. DOI:10.1136/bmj.326.7379.4
17. Salpeter S, Greyber E, Pasternak G, Salpeter E. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2006:CD002967.
18. Cryer DR, Nicholas SP, Henry DH, Mills DJ, Stadel BV. Comparative outcomes study of metformin intervention versus conventional approach the COSMIC Approach Study. Diabetes Care 2005;28:539-43.
19. Shenoy C. Metformin-associated lactic acidosis precipitated by acute renal failure. Am J Med Sci 2006;331:55-7. DOI 10.1097/00000441-200601000-00016
20. DePalo VA, Mailer K, Yoburn D, Crausman RS. Lactic acidosis. Lactic acidosis associated with metformin use in treatment of type 2 diabetes mellitus. Geriatrics 2005;60:3639-41.
21. Rachmani R, Slavachevski I, Levi Z, Zadok B, Kedar Y, Ravid M. Metformin in patients with type 2 diabetes mellitus: reconsideration of traditional contraindications. Eur J Intern Med 2002;13:428-33.
22. Holstein A, Stumvoll M. Contraindications can damage your health - is metformin a case in point? Diabetologia 2005;48:2454-9.
23. McCormack J, Johns K, Tildesley H. Metformin's contraindications should be contraindicated. CMAJ 2005;173:502-4.