Neuroprotection in glaucoma using calpain-1 inhibitors: Regional differences in calpain-1 activity in the trabecular meshwork, optic nerve and implications for therepeutics

CNS and Neurological Disorders - Drug Targets

Volumn 7, Issue 3, 2008, Pages 295-304

  Govindarajan, Bharathi ^a   Laird, James ^a   Sherman, Ronald ^b   Salomon, Robert G ^a   Bhattacharya, Sanjoy K ^c  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Calpain; Glaucoma; Isolevuglandin; Lipid oxidation; Neuroprotection; Posttranslational modifications; Trabecular meshwork

Indexed keywords

[1 [(1 FORMYL 2 PHENYLETHYL)CARBAMOYL] 2 METHYLPROPYL]CARBAMIC ACID BENZYL ESTER; CALPAIN 1; CALPASTATIN; CALPEPTIN; CYSTEINE PROTEINASE INHIBITOR; ISOPROTEIN; LEVUGLANDIN E2; PROTEASOME; SJA 6017;

AMINO ACID SEQUENCE; COMPETITIVE INHIBITION; COVALENT BOND; DEGENERATIVE DISEASE; DRUG MECHANISM; ENZYME ACTIVITY; GLAUCOMA; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIPID OXIDATION; NEUROPROTECTION; NONHUMAN; OPTIC NERVE LESION; OXIDATIVE STRESS; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROCESSING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; TRABECULAR MESHWORK; TRANSLATION REGULATION; UBIQUITINATION;

ANIMALS; CALPAIN; GLAUCOMA; GLYCOPROTEINS; HUMANS; NEUROPROTECTIVE AGENTS; OPTIC NERVE; TRABECULAR MESHWORK;

EID: 48249143207     PISSN: 18715273     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152708784936644     Document Type: Review

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