Proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis

Investigative Ophthalmology and Visual Science

Volumn 47, Issue 6, 2006, Pages 2508-2514

  Bhattacharya, Sanjoy K ^a,c   Crabb, John S ^a   Bonilha, Vera L ^a   Gu, Xiaorong ^a   Takahara, Hidenari ^b   Crabb, John W ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b IBARAKI UNIVERSITY   (Japan)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CITRULLINE; ENZYME; MESSENGER RNA; MYELIN BASIC PROTEIN; PEPTIDYL ARGININE DEIMINASE 2; POLYADENYLATED RNA; SHORT HAIRPIN RNA; HYDROLASE;

ADULT; AGED; ANIMAL CELL; ANIMAL MODEL; ARTICLE; ASTROCYTE; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; DBA 2 MOUSE; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; INTROSPECTION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; METHYLATION; MODULATION; MONITORING; MOUSE; MYELINATION; NONHUMAN; OPEN ANGLE GLAUCOMA; OPTIC NERVE; OPTIC NERVE LESION; PATHOGENESIS; PATHOLOGY; PRESSURE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; ANIMAL; C57BL MOUSE; DBA MOUSE; DISEASE MODEL; DOWN REGULATION; ENZYMOLOGY; GENETICS; METABOLISM; MIDDLE AGED; OPTIC NERVE DISEASE; RAT; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; ANIMALS; ARGININE; ASTROCYTES; BLOTTING, WESTERN; CITRULLINE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FEMALE; GLAUCOMA, OPEN-ANGLE; HUMANS; HYDROLASES; IMMUNOHISTOCHEMISTRY; MALE; METHYLATION; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MIDDLE AGED; OPTIC NERVE DISEASES; PROTEOMICS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 33745650746     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.05-1499     Document Type: Article

References (37)

1. Quigley HA. Number of people with glaucoma worldwide. Br J Ophthalmol. 1996;80:389-393.
2. Gordon MO, Beiser JA, Brandt JD, et al. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120:714-720.
3. Ahmed F, Torrado M, Johnson E, Morrison J, Tomarev SI. Changes in mRNA levels of the Myoc/Tigr gene in the rat eye after experimental elevation of intraocular pressure or optic nerve transsection. Invest Ophthalmol Vis Sci. 2001;42:3165-3172.
4. Clark AF, Kawase K, English-Wright S, et al. Expression of the glaucoma gene myocilin (MYOC) in the human optic nerve head. FASEB J. 2001;15:1251-1253.
5. Neufeld AH, Sawada A, Becker, B. Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma. Proc Natl Acad Sci USA. 1999;96:9944-9948.
6. Pena JD, Agapova O, Gabelt BT, et al. Increased elastin expression in astrocytes of the lamina cribrosa in response to elevated intraocular pressure. Invest Ophthalmol Vis Sci. 2001;42:2303-2314.
7. Bejjani BA, Xu L, Armstrong D, Lupski JR, Reneker LW. Expression patterns of cytochrome P4501B1 (Cyp1b1) in FVB/N mouse eyes. Exp Eye Res. 2002;75:249-257.
8. Ricard CS, Kobayashi S, Pena JD, et al. Selective expression of neural cell adhesion molecule (NCAM)-180 in optic nerve head astrocytes exposed to elevated hydrostatic pressure in vitro. Brain Res Mol Brain Res. 2000;81:62-79.
9. Salvador-Silva M, Ricard CS, Agapova OA, Yang P, Hernandez MR. Expression of small heat shock proteins and intermediate filaments in the human optic nerve head astrocytes exposed to elevated hydrostatic pressure in vitro. J Neurosci Res. 2001;66:59-73.
10. Yang P, Agapova O, Parker A, et al. DNA microarray analysis of gene expression in human optic nerve head astrocytes in response to hydrostatic pressure. Physiol Genomics. 2004;17:157-169.
11. Bhattacharya SK, Rockwood EJ, Smith SD, et al. Proteomics reveals cochlin deposits associated with glaucomatous trabecular meshwork. J Biol Chem. 2005;280:6080-6084.
12. Vossenaar ER, Zendman AJ, van Venrooij WJ, Pruijn, GJ. PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease. Bioessays. 2003;25:1106-1118.
13. Bhattacharya SK, Crabb JS, West KA, et al. Optic nerve fractionation for proteomics. In: Smejkal GB, Lazarev A, eds. Separation Methods in Proteomics. New York: Marcel Dekker; 2006:135-155.
14. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. New York: Cold Spring Harbor Laboratory Press; 1989.
15. Fuss B, Mallon B, Phan T, et al. Purification and analysis of in vivo-differentiated oligodendrocytes expressing the green fluorescent protein. Dev Biol. 2000;218:259-274.
16. Yang P, Hernandez MR. Purification of astrocytes from adult human optic nerve heads by immunopanning. Brain Res Brain Res Protoc. 2003;12:67-76.
17. Lee JH, Park EJ, Kim OS, et al. Double-stranded RNA-activated protein kinase is required for the LPS-induced activation of STAT1 inflammatory signaling in rat brain glial cells. Glia. 2005;50:66-79.
18. Asaga H, Akiyama K, Ohsawa T, Ishigami A. Increased and type II-specific expression of peptidylarginine deiminase in activated microglia but not hyperplastic astrocytes following kainic acid-evoked neurodegeneration in the rat brain. Neurosci Lett. 2002;326:129-132.
19. Asaga H, Ishigami A. Protein deimination in the rat brain after kainate administration: citrulline-containing proteins as a novel marker of neurodegeneration. Neurosci Lett. 2001;299:5-8.
20. John SW, Hagaman JR, MacTaggart TE, Peng L, Smithes O. Intraocular pressure in inbred mouse strains. Invest Ophthalmol Vis Sci. 1997;38:249-253.
21. Moscarello MA, Pritzker L, Mastronardi FG, Wood DD. Peptidylarginine deiminase: a candidate factor in demyelinating disease. J Neurochem. 2002;81:335-343.
22. Nakashima K, Hagiwara T, Yamada M. Nuclear localization of peptidylarginine deiminase V and histone deimination in granulocytes. J Biol Chem. 2002;277:49562-49568.
23. Cuthbert GL, Daujat S, Snowden AW, et al. Histone deimination antagonizes arginine methylation. Cell. 2004;118:545-553.
24. Wang Y, Wysocka J, Sayegh J, et al. Human PAD4 regulates histone arginine methylation levels via demethylimination. Science. 2004;306:279-283.
25. Scofield RH. Autoantibodies as predictors of disease. Lancet. 2004;363:1544-1546.
26. Chou SM, Wang HS, Taniguchi A. Role of SOD-1 and nitric oxide/ cyclic GMP cascade on neurofilament aggregation in ALS/MND. J Neurol Sci. 1996;139(suppl):16-26.
27. Carelli V, Ross-Cisneros FN, Sadun AA. Optic nerve degeneration and mitochondrial dysfunction: genetic and acquired optic neuropathies. Neurochem Int. 2002;40:573-584.
28. Kursula P, Tikkanen G, Lehto VP, Nishikimi M, Heape AM. Calcium-dependent interaction between the large myelin-associated glycoprotein and S100beta. J Neurochem. 1999;73:1724-1732.
29. Boggs JM, Yip PM, Rangaraj G, Jo E. Effect of posttranslational modifications to myelin basic protein on its ability to aggregate acidic lipid vesicles. Biochemistry. 1997;36:5065-5071.
30. Pritzker LB, Joshi S, Harauz G, Moscarello MA. Deimination of myelin basic protein. 2. Effect of methylation of MBP on its deimination by peptidylarginine deiminase. Biochemistry. 2000;39:5382-5388.
31. Gong H, Zolzer F, von Recklinghausen G, Havers W, Schweigerer L. Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cycle arrest and apoptosis. Leukemia. 2000;14:826-829.
32. Gong H, Zolzer F, von Recklinghausen G, et al. Arginine deiminase inhibits cell proliferation by arresting cell cycle and inducing apoptosis. Biochem Biophys Res Commun. 1999;261:10-14.
33. Akiyama K, Sakurai Y, Asou H, Senshu T. Localization of peptidylarginine deiminase type II in a stage-specific immature oligodendrocyte from rat cerebral hemisphere. Neurosci Lett. 1999;274:53-55.
34. Osborne NN, Ugarte M, Chao M, et al. Neuroprotection in relation to retinal ischemia and relevance to glaucoma. Surv Ophthalmol. 1999;43(suppl 1):S102-S128.
35. Marta CB, Davio C, Pasquini LA, Soto EF, Pasquini JM. Molecular mechanisms involved in the actions of apotransferrin upon the central nervous system: Role of the cytoskeleton and of second messengers. J Neurosci Res. 2002;69:488-496.
36. Libich DS, Hill CM, Bates IR, et al. Interaction of the 18.5-kD isoform of myelin basic protein with Ca2+ -calmodulin: effects of deimination assessed by intrinsic Trp fluorescence spectroscopy, dynamic light scattering, and circular dichroism. Protein Sci. 2003;12:1507-1521.
37. Sambandam T, Belousova M, Accaviti-Loper MA, et al. Increased peptidylarginine deiminase type II in hypoxic astrocytes. Biochem Biophys Res Commun. 2004;325:1324-1329.