Isotonic and hypertonic saline droplet deposition in a human upper airway model

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 19, Issue 2, 2006, Pages 184-198

  Zhang, Zhe ^a   Kleinstreuer, Clement ^a   Kim, Chong S ^b  

^a North Carolina State University   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Aerosol deposition; Computational fluid particle dynamics; Droplet vaporization and hygroscopicity; Isotonic and hypertonic saline droplets

Indexed keywords

ISOTONIC SOLUTION; SODIUM CHLORIDE;

AEROSOL; AIR TEMPERATURE; AIRFLOW; ARTICLE; COMPUTATIONAL FLUID DYNAMICS; COMPUTER SIMULATION; DENSITY; EVAPORATION; FLOW RATE; HUMIDITY; INHALATION; LAMINAR FLOW; MOUTH; PARTICLE SIZE; SOLUTE; TRACHEOBRONCHIAL TREE; TURBULENT FLOW; UPPER RESPIRATORY TRACT; VALIDATION PROCESS; VAPORIZATION; WATER VAPOR; WETTABILITY;

ADMINISTRATION, INHALATION; HUMANS; HUMIDITY; ISOTONIC SOLUTIONS; LUNG; MODELS, ANATOMIC; MODELS, BIOLOGICAL; PARTICLE SIZE; RESPIRATORY MECHANICS; SALINE SOLUTION, HYPERTONIC; THERMODYNAMICS; VOLATILIZATION; WETTABILITY;

EID: 33745620202     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.2006.19.184     Document Type: Article

References (41)

1. Laube, B.L., R. Jashnani, R.N. Dalby, et al. 2000. Targeting aerosol deposition in patients with cystic fibrosis: effects of alterations in particle size and inspiratory flow rate. Chest 118:1069-1076.
2. Khan, S.Y., and B.R. O'Driscoll. 2004. Is nebulized saline a placebo in COPD? BMC Pulmonary Med. 4:1-5. Also available from: 〈www.biomedcentral. com/1471-2466-4-9.〉
3. Sutton, P.P., H.G. Gemmell, N. Innes, et al. 1988. Use of nebulized saline and nebulized terbutaline as an adjunct to chest physiotherapy. Thorax 43:57-60.
4. Eng, P.A., J. Morton, J.A. Douglass, et al. 1996. Short-term efficacy of ultrasonically nebulized hypertonic saline in cystic fiberosis. Paediatr. Pulmonol. 21:77-83.
5. Broday, D.M., and P.G. Georgopoulos. 2001. Growth and deposition of hygroscopic particulate matter in the human lungs. Aerosol Sci. Technol. 34:144-159.
6. Ferron, G.A., W.G. Kreyling, and B. Haider. 1988. Inhalation of salt aerosol particles II. Growth and deposition in the human respiratory tract. J. Aerosol Sci. 19:611-631.
7. Finlay, W.H., and K.W. Stapleton. 1995. The effect on regional lung deposition of coupled heat and mass transfer between hygroscopic droplets and their surrounding phase. J. Aerosol Sci. 26:655-670.
8. Gebheart, J., A. Anselm, G. Ferron, et al. 1990. Experimental data on the total deposition of hygroscopic particles in the human respiratory tract. In S. Masuda and K. Takahashi, eds. Aerosols: Science, Industry, Health and Environment., Pergamon Press, Oxford, 1299-1302.
9. Hickey, A.J., and T.B. Martonen. 1991. Behavior of hygroscopic pharmaceutical aerosols and the influence of hydrophobic additives. Pharm. Res. 10:1-7.
10. Morrow, P.E. 1986. Factors determining hygroscopic aerosol deposition in airways. Physiol. Rev. 66:330-376.
11. Ferron, G.A., G. Oberdörster, and R. Henneberg. 1989. Estimation of the deposition of aerosolized drugs in the human respiratory tract due to hygroscopic growth. J. Aerosol Med. 2:271-284.
12. Eberl, S., H.K. Chan, E. Daviskas, et al. 2001. Aerosol deposition and clearance measurement: a novel technique using dynamic SPET. Eur. J. Nuclear Med. 28:1365-1372.
13. Chan, H.K., S. Eberl, E. Daviskas, et al. 2002. Changes in lung deposition of aerosols due to hygroscopic growth: a fast SPECT study. J. Aerosol Med. 15:307-311.
14. Weibel, E.R. 1963. Morphometry of the Human Lung. Academic Press, New York.
15. Cheng, K.H., Y.S. Cheng, H.C. Yeh, et al. 1997. Measurements of airway dimensions and calculation of mass transfer characteristics of the human oral passage. J. Biomech. Eng. 119:476-482.
16. Martonen, T.B., Y. Yang, and Z.Q. Xue. 1994. Influences of cartilaginous rings on tracheobronchial fluid dynamics. Inhal. Toxicol. 6:185-203.
17. Zhang, Z., and C. Kleinstreuer. 2003. Species heat and mass transfer in a human upper airway model. Int. J. Heat Mass Transfer 46:4755-4768.
18. Wilcox, D.C. 1998. Turbulence Modeling for CFD, 2nd ed. DCW Industries, Inc., LA Canada, CA.
19. Zhang, Z., and C. Kleinstreuer. 2003. Low Reynolds number turbulent flows in locally constricted conduits: a comparison study. AIAA J. 41:831-840.
20. Kleinstreuer, C., and Z. Zhang. 2003. Laminar-to-turbulent fluid-particle flows in a human airway model. Int. J. Multiphase Flow 29:271-289.
21. Zhang, Z., C. Kleinstreuer, and C.S. Kim. 2002. Cyclic micron-size particle inhalation and deposition in a triple bifurcation lung airway model. J. Aerosol Sci. 33:257-281.
22. nd ed. Hemisphere, Washington, D.C.
23. Finlay, W.H. 2001. The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction. Academic Press, London.
24. Daviskas, E., I. Gonda, and S.D. Anderson. 1990. Mathematical modeling of heat and water transport in human respiratory tract. J. Appl. Physiol. 69:362-372.
25. Zhang, Z., C. Kleinstreuer, J.F. Donohue, et al. 2005. Comparison of micro- and nano-size particle depositions in a human upper airway model. J. Aerosol Sci. 36:211-233.
26. Zhang, Z., C. Kleinstreuer, C.S. Kim, et al. 2004. Vaporizing micro-droplet inhalation, transport and deposition in a human upper airway model. Aerosol Sci. Technol. 38:36-49.
27. Longest, P.W., and C. Kleinstreuer. 2004. Interacting effects of uniform flow, plane shear, and near-wall proximity on the heat and mass transfer of respiratory aerosols. Int. J. Heat Mass Transfer 47:4745-4759.
28. Vesala, T., M. Kulmala, R. Rudolf, et al. 1997. Models for condensational growth and evaporation of binary aerosol particles. J. Aerosol Sci. 28:565.
29. Hinds, W.C. 1993. Physical and chemical changes in the particulate phase. In K. Willeke and P.A. Baron, eds. Aerosol Measurements, Principles, Techniques and Applications. Van Nostrand Reinhold, New York, pp. 41-53.
30. Peng, C., Chow A.H.L., and Chan, C.K. 2000. Study of the hygroscopic properties of selected pharmaceutical aerosols using single particle levitation. Pharm. Res. 17:1104-1109.
31. Cinkotai, F.F. 1971. The behavior of sodium chloride particles in moist air. J. Aerosol Sci. 2:325-329.
32. Zhang, Z., and C. Kleinstreuer. 2004. Airflow structures and nano-particle deposition in a human upper airway model. J. Comput. Physics 198:178-210.
33. AEA Technology. 2001. CFX-4.4: Solve. CFX International, Oxfordshire, UK.
34. Zhang, Z., and C. Kleinstreuer. 2002. Transient airflow structures and particle transport in a sequentially branching lung airway model. Physics Fluids 14:862-880.
35. Longest, P.W., C. Kleinstreuer, and J.R. Buchanan. 2004. Efficient computation of micro-particle dynamics including wall effects. Comput. Fluids 33:577-601.
36. Comer, J.K., C. Kleinstreuer, and Z. Zhang. 2001. Flow structures and particle deposition patterns in double bifurcation airway models. Part 1. Air flow fields. J. Fluid Mechanics 435:25-54.
37. Comer, J.K., C. Kleinstreuer, S. Hyun, et al. 2000. Aerosol transport and deposition in sequentially bifurcating airways. J. Biomech. Eng. 122:152-158.
38. Smolik, J., L. Dzumbova, J. Schwarz, et al. 2001. Evaporation of ventilated water droplet: connection between heat and mass transfer. J. Aerosol Sci. 32:739-748.
39. McFadden, E.R., B.M. Pichurko, H.F. Bowman, et al. 1985. Thermal mapping of the airways in humans. J. Appl Physiol. 58:564-570.
40. Zhang, Z., C. Kleinstreuer, and C.S. Kim. 2005. Water vapor transport and its effects on the deposition of hygroscopic droplets in a human upper airway model. Aerosol Sci. Tech. 40:1-16.
41. Ferron, G.A., B. Haider, and W.G. Kreyling. 1985. A method for the approximation of the relative humidity in the upper airways. Bull. Math. Biol. 47:565-589.