Integration of computer model of drug delivery with human subject testing

Computational Engineering

Volumn 4, Issue , 2003, Pages 135-145

  Martonen, T ^a   Hwang, D ^b   Fleming, J ^c  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b IBM   (United States)

^c SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL LABORATORIES; COMPUTER SIMULATION; DISEASES; MATHEMATICAL MODELS; PHARMACODYNAMICS; SYSTEMATIC ERRORS;

DRUG DELIVERY; HUMAN SUBJECT TESTING; LUNG STRUCTURES; PHARMACOLOGIC DRUGS;

DRUG DOSAGE;

EID: 4544287875     PISSN: 14667266     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (9)

1. Martonen, T.B., Musante, C.J., Segal, R.A., Schroeter, J.D., Hwang, D., Dolovich, M., Burton, R., Spencer, R.M., and Fleming, J.S. Lung models: strengths and limitations, Respir. Care 45: 712-736 (2000b).
2. Martonen, T.B., and Yang, Y. Deposition mechanics of pharmaceutical particles in human airways, In.: Inhalation Aerosols: Physical and Biological Basis for Therapy (Ed., Hickey, A.J.), Marcel Dekker, Inc., New York (1996).
3. Martonen, T.B., Schroeter, J.D., Hwang, D., Fleming, J.S., and Conway, J.H. Human lung morphology models for particle deposition studies, Inhal. Toxicol. 12: 109-121 (2000).
4. Fleming, J.S., Conway, J.H., Holgate, S.T., Moore, E.A., Hashish, A.H., Bailey, A.G., and Martonen, T.B. Evaluation of the accuracy and precision of lung aerosol deposition measurements from planar radionuclide imaging using simulation. Phys. Med. Biol. 43: 2423-2429 (1998).
5. Martonen, T.B., Hwang, D., Guan, X., and Fleming, J.S., Supercomputer description of human lung morphology for imaging analysis, J. Nucl. Med. 39: 745-750 (1998).
6. Martonen, T.B., Katz, I.M., and Cress, W. Aerosol deposition as a function of airway disease: cystic fibrosis. Pharm. Res. 12: 96-102 (1995a).
7. Segal, R.A., Martonen, T.B., Kim, C.S., and Shearer, M. Computer simulations of particle deposition in the lungs of chronic obstructive pulmonary disease patients. Inhal. Toxicol. 14: 705-720 (2002).
8. Katz, I.M., Schroeter, J.D., and Martonen, T.B. Factors affecting the deposition of aerosolized insulin, Diabetes Technology and Therapeutics 3: 387-397 (2001).
9. Schroeter, J.D., Fleming, J.S., Hwang, D., and Martonen, T.B. A computer model of lung morphology to analyze SPECT images, Comp. Med. Imag. Graphics 26: 237-246 (2002).