Experimental measurement and numerical study of particle deposition in highly idealized mouth-throat models

Aerosol Science and Technology

Volumn 40, Issue 5, 2006, Pages 361-372

  Zhang, Yu ^a   Chia, Tze Luck ^a   Finlay, Warren H ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AVERAGE CURVE; BEND REGIONS; COMPUTATIONAL FLUID DYNAMICS SIMULATIONS; CURVATURE RADII; EXPERIMENTAL MEASUREMENTS; HUMAN MOUTH; IMPACTORS; IN-VITRO; IN-VIVO; INHALATION DEVICES; INNER DIAMETERS; KEY DIMENSIONS; MASS MEDIAN DIAMETERS; MONODISPERSE PARTICLES; NUMERICAL STUDIES; OPTIMIZATION DESIGN; PARTICLE DEPOSITIONS; PRELIMINARY EXPERIMENTAL DATA; REYNOLDS NUMBER EFFECT; TUBE INLETS;

DEPOSITION; GEOMETRY; REYNOLDS NUMBER;

COMPUTATIONAL FLUID DYNAMICS;

EID: 34247611172     PISSN: 02786826     EISSN: 15217388     Source Type: Journal    
DOI: 10.1080/02786820600615055     Document Type: Article

References (21)

1. Cass, M. R. L., Brown, J., Ickford, P., Fayinka, S., Newman, P. S., Johansson, J. C., and Bye, A. (1999). Pharmacoscintigraphic Evaluation of Lung Deposition of Inhaled Zanamivir in Healthy Volunteers, Clin. Pharmacokinetics 36(Suppl.1):21-31.
2. Clark, A. R., and Hollingworth, A. M. (1993). The Relationship Between Powder Inhaler Resistance and Peak Inspiratory Conditions in Healthy Volunteers Implications for In Vivo Testing, J. Aerosol Med. 6:99-110.
3. DeHaan,W. H., and Finlay,W. H. (2001). In Vitro Monodisperse Aerosol Deposition in a Mouth and Throat with Six Different Inhalation Devices, J. Aerosol Med. 14(3):361-367.
4. DeHaan, W. H., and Finlay, W. H. (2004). Predicting Extrathoracic Deposition from Dry Powder Inhalers, J. Aerosol Sci. 35:309-331.
5. Emmett, P. C., Aitken, R. J., and Hannan, W. J. (1982). Measurements of the Total and Regional Deposition of Inhaled Particles in the Human Respiratory Tract, J. Aerosol Sci. 13:549-560.
6. Finlay, W. H. (2001). The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction. Academic Press, London.
7. Finlay, W. H., Zhang, Y., Grgic, B., Heenan, A., Burnell, P., Matida, E. A., Pollard, A., and Lange, C. F. (2004). Solving a Major In Vitro-In Vivo Correlation Problem: Impactor Induction Ports. In R. N. Dallby, P. R. Byron, J. Peart, J. D. Suman, and S. J. Farr, eds. Respiratory Drug Delivery IX, volume I, pages 203-210, Palm Desert, Califonia. Respiratory Drug Delivery, Davis Healthcare Intnational Publishing, LLC, River Grove, Illinois, USA.
8. Foord, N., Black, A., andWalsh, M. (1978). Regional Deposition of 2.5-7.5 μm Diameter Inhaled Particles in Healthy Male Non-Smokers, J. Aerosol Sci. 9:343-357.
9. Grgic, B., Finlay,W. H., and Heenan, A. F. (2004). Regional Aerosol Deposition and Flow Measurements in an Idealized Mouth and Throat, J. Aerosol Sci. 35:21-32.
10. Heenan, A. F., Matida, E. A., Pollard, A., and Finlay,W. H. (2003). Experimental Measurements and Computational Modeling of the Flow in an Idealized Extrathoracic Airway, Exp. Fluids. (35):70-84.
11. Matida, E. A., Finlay, W. H., Lange, C. F., and Grgic, B. (2004). Improved Numerical Simulation of Aerosol Deposition in an Idealized Mouth-Throat, J. Aerosol Sci. 35:1-19.
12. McFarland, A. R., Gong, H., Muyshond, A., Wente, W. B., and Anand, N. K. (1997). Aerosol Deposition in Bends with Turbulent Flow, Environ. Sci. Technol. 31(12):3371-3377.
13. Pui, D. Y. H., Novas, F. R., and Liu, B. Y. H. (1987). Experimental Study of Particle Deposition in Bends of Circular Cross Section, Aerosol Sci. Technol. 7:301-315.
14. Stahlhofen,W., Gebhart, J., and Heyder, J. (1980). Experimental Determination of the Regional Deposition of Aerosol Particles in the Human Respiratory Tract, Am. Ind. Hyg. Assoc. J. 41(6):385-398a.
15. Stahlhofen, W., Gebhard, J., and Heyder, J. (1981). Biological Variability of Regional Deposition of Aerosol Particles in the Human Respiratory Tract, Am. Ind. Hyg. Assoc. J. 42:348-352.
16. Stahlhofen,W., Gebhard, J., Heyder, J., and Scheuch, G. (1983). New Regional Deposition Data of the Human Respiratory Tract, J. Aerosol Sci. 14:186-188.
17. Stahlhofen,W., Gebhard, J., Heyder, J., Scheuch, G., and Juraske, P. (1984). Particle Deposition in Extrathoracic Airways of Healthy Subjects and of Patients with Early Stages of Laryngeal Carcinoma, J. Aerosol Sci. 15:115-117.
18. Stahlhofen, W., Rudolf, G., and James, A. C. (1989). Intercomparison of Experimental Regional Aerosol Deposition Data, J. Aerosol Med. 2(3):285-308.
19. Stapleton, K. W., Guentsch, E., Hoskinson, M. K., and Finlay, W. H. (2000). On the Suitability of k-ε Turbulence Modeling for Aerosol Deposition in the Mouth and Throat:AComparison with Experiment, J. Aerosol Sci. 31(6):739-749.
20. Wilcox, D. C. (1988). Reassessment of the Scale Determining Equation for Advanced Turbulence Models, AIAA J. 26(11):1299-1310.
21. Zhang, Y., Finlay, W. H., and Matida, E. A. (2004). Particle Deposition Measurements and Numerical Simulation in a Highly Idealized Mouth-Throat, J. Aerosol Sci. 35:789-803.