M867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated Lung cancer models

PLoS ONE

Volumn 3, Issue 5, 2008, Pages

  Kim, Kwang Woo ^a   Moretti, Luigi ^a   Lu, Bo ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 7; KI 67 ANTIGEN; M 867; MATRIGEL; PROTEIN BAK; PROTEIN BAX; VON WILLEBRAND FACTOR; CYSTEINE PROTEINASE INHIBITOR; M867 COMPOUND; OXADIAZOLE DERIVATIVE; PYRAZINE DERIVATIVE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CANCER CELL CULTURE; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER RESEARCH; CELL ASSAY; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DISEASE MODEL; DRUG SELECTIVITY; DRUG TOLERABILITY; EMBRYO; EMBRYO CELL; ENZYME INHIBITION; FEMALE; FIBROBLAST CULTURE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; INTERMETHOD COMPARISON; IONIZING RADIATION; KNOCKOUT MOUSE; LUNG CANCER; MOUSE; NICK END LABELING; NONHUMAN; RADIOSENSITIVITY; TREATMENT FAILURE; TREATMENT OUTCOME; TUMOR GROWTH; TUMOR VASCULARIZATION; VASCULAR ENDOTHELIUM; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; LUNG TUMOR; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PATHOLOGY; RADIATION DOSE; TUMOR CELL LINE; VASCULARIZATION; XENOGRAFT;

ANIMALS; APOPTOSIS; AUTOPHAGY; BASE SEQUENCE; CASPASE 3; CELL LINE, TUMOR; CYSTEINE PROTEINASE INHIBITORS; HUMANS; LUNG NEOPLASMS; MICE; MICE, KNOCKOUT; OXADIAZOLES; PYRAZINES; RADIATION TOLERANCE; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS;

EID: 48249123422     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002275     Document Type: Article

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