Dual knockdown of p65 and p50 subunits of NF-kappaB by siRNA inhibits the induction of inflammatory cytokines and significantly enhance apoptosis in human primary synoviocytes treated with tumor necrosis factor-alpha

Molecular Biology Reports

Volumn 35, Issue 3, 2008, Pages 291-298

  Lee, Ui Jin ^c   Choung, So Rim ^a   Prakash, K V Bhanu ^c   Lee, Eun Ju ^a   Lee, Mi Young ^a   Kim, Young Joo ^b   Han, Chang Whan ^c   Choi, Young Chul ^a  

^a Bioneer Corporation   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Daejeon St Mary's Hospital   (South Korea)

Author keywords

Apoptosis; Fibroblast like synoviocyte; NF B p65; p50; Rheumatoid arthritis; siRNA

Indexed keywords

ANTIINFLAMMATORY AGENT; CHEMOKINE; CYTOKINE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P50; PROTEIN SUBUNIT; REL 1096; SMALL INTERFERING RNA; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN TARGETING; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; SYNOVITIS;

APOPTOSIS; CELLS, CULTURED; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; NF-KAPPA B P50 SUBUNIT; RNA, SMALL INTERFERING; SYNOVIAL MEMBRANE; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 48249121188     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-007-9084-4     Document Type: Article

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