-
1
-
-
0033517989
-
Lipoproteins take their toll on the host
-
Janeway CA Jr, Medzhitov R. (1999) Lipoproteins take their toll on the host. Curr. Biol. 9:R879-82.
-
(1999)
Curr. Biol
, vol.9
-
-
Janeway Jr, C.A.1
Medzhitov, R.2
-
2
-
-
0031050034
-
Innate immunity: Impact on the adaptive immune response
-
Medzhitov R, Janeway CA Jr. (1997) Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol. 9:4-9.
-
(1997)
Curr. Opin. Immunol
, vol.9
, pp. 4-9
-
-
Medzhitov, R.1
Janeway Jr., C.A.2
-
4
-
-
13644270638
-
Toll-like receptor 4 coupled GI protein signaling pathways regulate extracellular signal-regulated kinase phosphorylation and AP-1 activation independent of NF kappa B activation
-
Fan H, Peck OM, Tempel GE, Halushka PV, Cook JA. (2004) Toll-like receptor 4 coupled GI protein signaling pathways regulate extracellular signal-regulated kinase phosphorylation and AP-1 activation independent of NF kappa B activation. Shock. 22:57-62.
-
(2004)
Shock
, vol.22
, pp. 57-62
-
-
Fan, H.1
Peck, O.M.2
Tempel, G.E.3
Halushka, P.V.4
Cook, J.A.5
-
5
-
-
33749077070
-
Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins
-
Fan H et al. (2006) Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins. Biochim. Biophys. Acta 1763:1051-8.
-
(2006)
Biochim. Biophys. Acta
, vol.1763
, pp. 1051-1058
-
-
Fan, H.1
-
6
-
-
22444449303
-
Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: Role of heterotrimeric Galpha(i) proteins
-
Fan H et al. (2005) Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins. Am. J. Physiol. Cell. Physiol. 289:C293-301.
-
(2005)
Am. J. Physiol. Cell. Physiol
, vol.289
-
-
Fan, H.1
-
7
-
-
15444368572
-
Mastoparan, a G protein agonist peptide, differentially modulates TLR4-and TLR2-mediated signaling in human endothelial cells and murine macrophages
-
Lentschat A et al. (2005) Mastoparan, a G protein agonist peptide, differentially modulates TLR4-and TLR2-mediated signaling in human endothelial cells and murine macrophages. J. Immunol. 174:4252-61.
-
(2005)
J. Immunol
, vol.174
, pp. 4252-4261
-
-
Lentschat, A.1
-
9
-
-
30744456497
-
Oxidants selectively reverse TGF-beta suppression of proinflammatory mediator production
-
Xiao YQ et al. (2006) Oxidants selectively reverse TGF-beta suppression of proinflammatory mediator production. J. Immunol. 176:1209-17.
-
(2006)
J. Immunol
, vol.176
, pp. 1209-1217
-
-
Xiao, Y.Q.1
-
10
-
-
0037177841
-
Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta
-
Xiao YQ et al. (2002) Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta. J. Biol. Chem. 277:14884-93.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 14884-14893
-
-
Xiao, Y.Q.1
-
11
-
-
33144460185
-
Dynamic regulation of proand anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses
-
Chi H et al. (2006) Dynamic regulation of proand anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc. Natl. Acad. Sci. U. S. A. 103:2274-9.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A
, vol.103
, pp. 2274-2279
-
-
Chi, H.1
-
12
-
-
31344442772
-
MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock
-
Zhao Q et al. (2006) MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. J. Exp. Med. 203:131-40.
-
(2006)
J. Exp. Med
, vol.203
, pp. 131-140
-
-
Zhao, Q.1
-
13
-
-
0029095166
-
The serine/threonine phosphatase inhibitor, calyculin A, inhibits and dissociates macrophage responses to lipopolysaccharide
-
Barber SA, Perera PY, McNally R, Vogel SN. (1995) The serine/threonine phosphatase inhibitor, calyculin A, inhibits and dissociates macrophage responses to lipopolysaccharide. J. Immunol. 155:1404-10.
-
(1995)
J. Immunol
, vol.155
, pp. 1404-1410
-
-
Barber, S.A.1
Perera, P.Y.2
McNally, R.3
Vogel, S.N.4
-
14
-
-
0034244109
-
Suppression of Cox-2 and TNF-alpha mRNA in endotoxin tolerance: Effect of cycloheximide, antinomycin D, and okadaic acid
-
Fernando LP, Fernando AN, Ferlito M, Halushka PV, Cook JA. (2000) Suppression of Cox-2 and TNF-alpha mRNA in endotoxin tolerance: effect of cycloheximide, antinomycin D, and okadaic acid. Shock. 14:128-33.
-
(2000)
Shock
, vol.14
, pp. 128-133
-
-
Fernando, L.P.1
Fernando, A.N.2
Ferlito, M.3
Halushka, P.V.4
Cook, J.A.5
-
15
-
-
0033628155
-
Serine/threonine phosphorylation in cellular signaling for alveolar macrophage phagocytic response to endotoxin
-
Zhang P, Nelson S, Summer WR, Spitzer JA. (2000) Serine/threonine phosphorylation in cellular signaling for alveolar macrophage phagocytic response to endotoxin. Shock. 13:34-40.
-
(2000)
Shock
, vol.13
, pp. 34-40
-
-
Zhang, P.1
Nelson, S.2
Summer, W.R.3
Spitzer, J.A.4
-
16
-
-
14844362908
-
Inhibition of neutrophil apoptosis by TLR agonists in whole blood: Involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad
-
Francois S et al. (2005) Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad. J. Immunol. 174:3633-42.
-
(2005)
J. Immunol
, vol.174
, pp. 3633-3642
-
-
Francois, S.1
-
17
-
-
0037199972
-
The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
-
Guha M, Mackman N. (2002) The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J. Biol. Chem. 277:32124-32.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 32124-32132
-
-
Guha, M.1
Mackman, N.2
-
18
-
-
0027232391
-
The bioactive phospholipid lysophosphatidic acid is released from activated platelets
-
Eichholtz T, Jalink K, Fahrenfort I, Moolenaar WH. (1993) The bioactive phospholipid lysophosphatidic acid is released from activated platelets. Biochem. J. 291:677-80.
-
(1993)
Biochem. J
, vol.291
, pp. 677-680
-
-
Eichholtz, T.1
Jalink, K.2
Fahrenfort, I.3
Moolenaar, W.H.4
-
19
-
-
0035007140
-
Topical application of the phospholipid growth factor lysophosphatidic acid promotes wound healing in vivo
-
Balazs L, Okolicany J, Ferrebee M, Tolley B, Tigyi G. (2001) Topical application of the phospholipid growth factor lysophosphatidic acid promotes wound healing in vivo. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280:R466-72.
-
(2001)
Am. J. Physiol. Regul. Integr. Comp. Physiol
, vol.280
-
-
Balazs, L.1
Okolicany, J.2
Ferrebee, M.3
Tolley, B.4
Tigyi, G.5
-
20
-
-
0037162025
-
Lysophospholipids and their G protein-coupled receptors in inflammation and immunity
-
Graler MH, Goetzl EJ. (2002) Lysophospholipids and their G protein-coupled receptors in inflammation and immunity. Biochim. Biophys. Acta 1582:168-74.
-
(2002)
Biochim. Biophys. Acta
, vol.1582
, pp. 168-174
-
-
Graler, M.H.1
Goetzl, E.J.2
-
21
-
-
0033614847
-
Structure-activity analysis of the effects of lysophosphatidic acid on platelet aggregation
-
Gueguen G et al. (1999) Structure-activity analysis of the effects of lysophosphatidic acid on platelet aggregation. Biochemistry. 38:8440-50.
-
(1999)
Biochemistry
, vol.38
, pp. 8440-8450
-
-
Gueguen, G.1
-
24
-
-
0038152846
-
Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family
-
Noguchi K, Ishii S, Shimizu T. (2003) Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J. Biol. Chem. 278:25600-6.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 25600-25606
-
-
Noguchi, K.1
Ishii, S.2
Shimizu, T.3
-
25
-
-
0037422595
-
Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist
-
McIntyre TM et al. (2003) Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist. Proc. Natl. Acad. Sci. U. S. A. 100:131-6.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A
, vol.100
, pp. 131-136
-
-
McIntyre, T.M.1
-
26
-
-
33845710345
-
Lysophosphatidic acid reduces the organ injury caused by endotoxemia-a role for G-protein-coupled receptors and peroxisome proliferator-activated receptor-gamma
-
Murch O, Collin M, Thiemermann C. (2007) Lysophosphatidic acid reduces the organ injury caused by endotoxemia-a role for G-protein-coupled receptors and peroxisome proliferator-activated receptor-gamma. Shock. 27:48-54.
-
(2007)
Shock
, vol.27
, pp. 48-54
-
-
Murch, O.1
Collin, M.2
Thiemermann, C.3
-
27
-
-
0036190344
-
Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappaB and AP-1 activation and enhances myocardial damage
-
Zingarelli B et al. (2002) Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappaB and AP-1 activation and enhances myocardial damage. Faseb. J. 16:327-42.
-
(2002)
Faseb. J
, vol.16
, pp. 327-342
-
-
Zingarelli, B.1
-
28
-
-
21744458404
-
15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock
-
Kaplan JM et al. (2005) 15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock. Shock. 24:59-65.
-
(2005)
Shock
, vol.24
, pp. 59-65
-
-
Kaplan, J.M.1
-
29
-
-
0033524913
-
Lysophosphatidic acid activates NF-kappaB in fibroblasts. A requirement for multiple inputs
-
Shahrestanifar M, Fan X, Manning DR. (1999) Lysophosphatidic acid activates NF-kappaB in fibroblasts. A requirement for multiple inputs. J. Biol. Chem. 274:3828-33.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 3828-3833
-
-
Shahrestanifar, M.1
Fan, X.2
Manning, D.R.3
-
30
-
-
17644405062
-
Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammation
-
Zingarelli B, Cook JA. (2005) Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammation. Shock. 23:393-9.
-
(2005)
Shock
, vol.23
, pp. 393-399
-
-
Zingarelli, B.1
Cook, J.A.2
-
31
-
-
25444495647
-
beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts
-
Gesty-Palmer D, El Shewy H, Kohout TA, Luttrell LM. (2005) beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. J. Biol. Chem. 280:32157-67.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 32157-32167
-
-
Gesty-Palmer, D.1
El Shewy, H.2
Kohout, T.A.3
Luttrell, L.M.4
-
32
-
-
0032938716
-
Regulation of tyrosine kinase cascades by G-protein-coupled receptors
-
Luttrell LM, Daaka Y, Lefkowitz RJ. (1999) Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr. Opin. Cell. Biol. 11:177-83.
-
(1999)
Curr. Opin. Cell. Biol
, vol.11
, pp. 177-183
-
-
Luttrell, L.M.1
Daaka, Y.2
Lefkowitz, R.J.3
-
33
-
-
0034617274
-
Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1
-
Yang H, Young DW, Gusovsky F, Chow JC. (2000) Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1. J. Biol. Chem. 275:20861-6.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 20861-20866
-
-
Yang, H.1
Young, D.W.2
Gusovsky, F.3
Chow, J.C.4
-
34
-
-
22844436330
-
Inhibition of extracellular signal-regulated kinase 1/2 augments nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophage cells
-
Koide N et al. (2005) Inhibition of extracellular signal-regulated kinase 1/2 augments nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophage cells. FEMS Immunol. Med. Microbiol. 45:213-9.
-
(2005)
FEMS Immunol. Med. Microbiol
, vol.45
, pp. 213-219
-
-
Koide, N.1
-
35
-
-
4143114777
-
15-deoxy-delta12,14- prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity
-
Ruiz PA, Kim SC, Sartor RB, Haller D. (2004) 15-deoxy-delta12,14- prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity. J. Biol. Chem. 279:36103-11.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 36103-36111
-
-
Ruiz, P.A.1
Kim, S.C.2
Sartor, R.B.3
Haller, D.4
-
36
-
-
2142658762
-
Evidence for nucleotide receptor modulation of cross talk between MAP kinase and NF-kappa B signaling pathways in murine RAW 264.7 macrophages
-
Aga M et al. (2004) Evidence for nucleotide receptor modulation of cross talk between MAP kinase and NF-kappa B signaling pathways in murine RAW 264.7 macrophages. Am. J. Physiol. Cell. Physiol. 286:C923-30.
-
(2004)
Am. J. Physiol. Cell. Physiol
, vol.286
-
-
Aga, M.1
-
37
-
-
0037088605
-
A differential role for the mitogen-activated protein kinases in lipopolysaccharide signaling: The MEK/ERK pathway is not essential for nitric oxide and interleukin 1beta production
-
Watters JJ et al. (2002) A differential role for the mitogen-activated protein kinases in lipopolysaccharide signaling: the MEK/ERK pathway is not essential for nitric oxide and interleukin 1beta production. J. Biol. Chem. 277:9077-87.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 9077-9087
-
-
Watters, J.J.1
-
38
-
-
0029043589
-
Modulation of superoxide generation in in vivo lipopolysaccharide-primed rat alveolar macrophages by arachidonic acid and inhibitors of protein kinase C, phospholipase A2, protein serine-threonine phosphatase(s), protein tyrosine kinase(s) and phosphatase(s)
-
Mayer AM, Brenic S, Stocker R, Glaser KB. (1995) Modulation of superoxide generation in in vivo lipopolysaccharide-primed rat alveolar macrophages by arachidonic acid and inhibitors of protein kinase C, phospholipase A2, protein serine-threonine phosphatase(s), protein tyrosine kinase(s) and phosphatase(s). J. Pharmacol. Exp. Ther. 274:427-36.
-
(1995)
J. Pharmacol. Exp. Ther
, vol.274
, pp. 427-436
-
-
Mayer, A.M.1
Brenic, S.2
Stocker, R.3
Glaser, K.B.4
-
39
-
-
0027456593
-
Stimulation of interleukin-1 alpha and interleukin-1 beta production in human monocytes by protein phosphatase 1 and 2A inhibitors
-
Sung SJ, Walters JA. (1993) Stimulation of interleukin-1 alpha and interleukin-1 beta production in human monocytes by protein phosphatase 1 and 2A inhibitors. J. Biol. Chem. 268:5802-9.
-
(1993)
J. Biol. Chem
, vol.268
, pp. 5802-5809
-
-
Sung, S.J.1
Walters, J.A.2
-
40
-
-
0037629646
-
PI3K and negative regulation of TLR signaling
-
Fukao T, Koyasu S. (2003) PI3K and negative regulation of TLR signaling. Trends. Immunol. 24:358-63.
-
(2003)
Trends. Immunol
, vol.24
, pp. 358-363
-
-
Fukao, T.1
Koyasu, S.2
-
41
-
-
33747202486
-
The phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharide
-
Peck OM et al. (2006) The phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharide. Shock. 26:31-6.
-
(2006)
Shock
, vol.26
, pp. 31-36
-
-
Peck, O.M.1
-
42
-
-
13444302907
-
Up-regulation of interleukin-6 in human ovarian cancer cell via a Gi/PI3K-Akt/NF-kappaB pathway by lysophosphatidic acid, an ovarian cancer-activating factor
-
Chou CH et al. (2005) Up-regulation of interleukin-6 in human ovarian cancer cell via a Gi/PI3K-Akt/NF-kappaB pathway by lysophosphatidic acid, an ovarian cancer-activating factor. Carcinogenesis. 26:45-52.
-
(2005)
Carcinogenesis
, vol.26
, pp. 45-52
-
-
Chou, C.H.1
-
43
-
-
34247850836
-
The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury
-
Deng W et al. (2007) The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury. Gastroenterology. 132:1834-51.
-
(2007)
Gastroenterology
, vol.132
, pp. 1834-1851
-
-
Deng, W.1
-
44
-
-
0030886445
-
The small GTP-binding protein Rho links G protein-coupled receptors and G alpha12 to the serum response element and to cellular transformation
-
Fromm C, Coso OA, Montaner S, Xu N, Gutkind JS. (1997) The small GTP-binding protein Rho links G protein-coupled receptors and G alpha12 to the serum response element and to cellular transformation. Proc. Natl. Acad. Sci. U. S. A. 94:10098-103.
-
(1997)
Proc. Natl. Acad. Sci. U. S. A
, vol.94
, pp. 10098-10103
-
-
Fromm, C.1
Coso, O.A.2
Montaner, S.3
Xu, N.4
Gutkind, J.S.5
-
45
-
-
0035658526
-
Enhancement of survival by LPA via Erk1/Erk2 and PI 3-kinase/Akt pathways in a murine hepatocyte cell line
-
Sautin YY, Crawford JM, Svetlov SI. (2001) Enhancement of survival by LPA via Erk1/Erk2 and PI 3-kinase/Akt pathways in a murine hepatocyte cell line. Am. J. Physiol. Cell. Physiol. 281:C2010-9.
-
(2001)
Am. J. Physiol. Cell. Physiol
, vol.281
-
-
Sautin, Y.Y.1
Crawford, J.M.2
Svetlov, S.I.3
-
46
-
-
0034624060
-
Dual regulation of Akt/protein kinase B by heterotrimeric G protein subunits
-
Bommakanti RK, Vinayak S, Simonds WF. (2000) Dual regulation of Akt/protein kinase B by heterotrimeric G protein subunits. J. Biol. Chem. 275:38870-6.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 38870-38876
-
-
Bommakanti, R.K.1
Vinayak, S.2
Simonds, W.F.3
|