Toll-like receptor 4 coupled GI protein signaling pathways regulate extracellular signal-regulated kinase phosphorylation and AP-1 activation independent of NFκB activation

Shock

Volumn 22, Issue 1, 2004, Pages 57-62

  Fan, Hongkuan ^a   Peck, Octavia M ^a   Tempel, George E ^a   Halushka, Perry V ^a   Cook, James A ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Endotoxin; Mitogen activated protein kinase; Pertussis toxin; Signal transduction; Transcription factor

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PERTUSSIS TOXIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INFLAMMATION; MEDIATOR RELEASE; PLASMID; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

CELL LINE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; INFLAMMATION; KIDNEY; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; PERTUSSIS TOXIN; PHOSPHORYLATION; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TRANSCRIPTION FACTOR AP-1;

EID: 13644270638     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000129759.58490.d6     Document Type: Article

References (36)

1. Karima R, Matsumoto S, Higashi H, Matsushima K: The molecular pathogenesis of endotoxic shock and organ failure. Mol Med Today 5:123-132, 1999.
2. Juan TS, Hailman E, Kelley MJ, Busse LA, Davy E, Empig CJ, Narhi LO, Wright SD, Lichenstein HS: Identification of a lipopolysaccharide binding domain in CD14 between amino acids 57 and 64. J Biol Chem 270:5219-5224, 1995.
3. Kawasaki K, Akashi S, Shimazu R, Yoshida T, Miyake K, Nishijima M: Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by taxol. J Biol Chem 275:2251-2254, 2000.
4. Ingalls RR, Monks BG, Savedra R Jr, Christ WJ, Delude RL, Medvedev AE, Espevik T, Golenbock DT: CD11/CD18 and CD14 share a common lipid A signaling pathway. J Immunol 161:5413-5420, 1998.
5. Triantafilou K, Triantafilou M, Dedrick RL: A CD14-independent LPS receptor cluster. Nature Immunol 2:338-345, 2001.
6. Inohara N, Ogura Y, Chen FF, Muto A, Nunez G: Human Nod1 confers responsiveness to bacterial lipopolysaccharides. J Biol Chem 276:2551-2554, 2001.
7. Poltorak A, He X, Smirnova I, Liu MY, Huffel CV, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B: Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-2088, 1998.
8. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr: A human homologue of the Drosophila toll protein signals activation of adaptive immunity. Nature 388:394-397, 1997.
9. Tamandl D, Bahrami M, Wessner B, Weigel G, Ploder M, Furst W, Roth E, Boltz-Nitulescu G, Spittler A: Modulation of toll-like receptor 4 expression on human monocytes by tumor necrosis factor and interleukin-6: tumor necrosis factor evokes lipopolysaccharide hyporesponsiveness, whereas interleukin-6 enhances lipopolysaccharide activity. Shock 20:224-229, 2003.
10. Horng T, Barton GM, Medzhitov R: TIRAP: an adapter molecule in the toll signaling pathway. Nature Immunol 2:835-841, 2001.
11. Cuschieri J, Bulmus V, Gourlay D, Garcia I, Hoffman A, Stayton P, Maier RV: Modulation of macrophage responsiveness to lipopolysaccharide by IRAK-1 manipulation. Shock 21:182-188, 2004.
12. Zhang G, Ghosh S: Negative regulation of toll-like receptor-mediated signaling by Tollip. J Biol Chem 277:7059-7065, 2002.
13. Ferlito M, Squadrito F, Halushka PV, Cook JA: Signal transduction events in Chinese hamster ovary cells expressing human CD14; effect of endotoxin desensitization. Shock 15:291-296, 2001.
14. i proteins and Src tyrosine kinases in endotoxin-induced signal transduction events and mediator production. J Endotoxin Res 8:427-435, 2003.
15. Solomon KR, Kurt-Jones EA, Saladino RA, Stack AM, Dunn IF, Ferretti M, Golenbock D, Fleisher GR, Finberg RW: Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both in vivo and in vitro responses to lipopolysaccharide. J Clin Invest 102:2019-2027, 1998.
16. 2 synthesis in cultured rat mesangial cells. Biochim Biophys Acta 963:429-435, 1988.
17. Zhang X, Morrison DC: Lipopolysaccharide-induced selective priming effects on tumor necrosis factor alpha and nitric oxide production in mouse peritoneal macrophages. J Exp Med 177:511-516, 1993.
18. Frantz S, Kobzik L, Kim YD, Fukazawa R, Medzhitov R, Lee RT, Kelly RA: Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J Clin Invest 104:271-280, 1999.
19. Gilchrist A, Bunemann M, Li A, Hosey MM, Hamm HE: A dominant-negative strategy for studying roles of G proteins in vivo. J Biol Chem 274:6610-6616, 1999.
20. Gilchrist A, Vanhauwe JF, Li A, Thomas TO, Voyno-Yasenetskaya T, Hamm HE: G alpha minigenes expressing C-terminal peptides serve as specific inhibitors of thrombin-mediated endothelial activation. J Biol Chem 276:25672-25679, 2001.
21. 2+ and mitogen-activated protein kinase regulation. J Biol Chem 269:1889-1895, 1994.
22. Inoue S, Hoshino S, Kukimoto I, Ui M, Katada T: Purification and characterization of the G203T mutant alpha i-2 subunit of GTP-binding protein expressed in baculovirus-infected Sf9 cells. J Biochem. (Tokyo) 118:650-657, 1995.
23. Hawes BE, van Biesen T, Koch WJ, Luttrell LM, Lefkowitz RJ: Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation. J Biol Chem 270:17148-17153, 1995.
24. Luttrell LM, Daaka Y, Lefkowitz RJ: Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol 11:177-183, 1999.
25. Blaukat A, Barac A, Cross MJ, Offermanns S, Dikic I: G protein-coupled receptor-mediated mitogen-activated protein kinase activation through cooperation of Galpha(q) and Galpha(i) signals. Mol Cell Biol 20:6837-6848, 2000.
26. Hallak H, Seiler AE, Green JS, Ross BN, Rubin R: Association of heterotrimeric G(i) with the insulin-like growth factor-I receptor. Release of G(beta-gamma) subunits upon receptor activation. J Biol Chem 275:2255-2258, 2000.
27. Dalle S, Ricketts W, Imamura T, Vollenweider P, Olefsky JM: Insulin and insulin-like growth factor I receptors utilize different G protein signaling components. J Biol Chem 276:15688-15695, 2001.
28. Ling K, Wang P, Zhao J, Wu YL, Cheng ZJ, Wu GX, Hu W, Ma L, Pei G: Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors. Proc Natl Acad Sci USA 96:7922-7927, 1999.
29. Saito N, Yamada Y, Sannohe S, Honda K, Adachi T, Kayaba H, Chihara J: Possible involvement of C-C chemokines in functional augmentation of adhesion molecules in asthmatic patients. Lung 180:251-263, 2002.
30. McGowan JEJr: Increasing threat of gram-positive bacterial infections in the intensive care unit setting. Crit Care Med 29:N69-N74, 2001.
31. Hildebrand F, Pape HC, Hoevel P, Krettek C, van Griensven M: The importance of systemic cytokines in the pathogenesis of polymicrobial sepsis and dehydroepiandrosterone treatment in a rodent model. Shock 20:338-346, 2003.
32. Vianna RC, Gomes RN, Bozza FA, Amancio RT, Bozza PT, David CM, Castro-Faria-Neto HC: Antibiotic treatment in a murine model of sepsis: impact on cytokines and endotoxin release. Shock 21:115-120, 2004.
33. Fan H, Teti G, Ashton S, Guyton K, Tempel GE, Halushka PV, Cook JA: Involvement of Gi proteins and Src tyrosine kinase in TNFα production induced by lipopolysaccharide, group B streptococci and Staphylococcus aureus. Cytokine 21:1-8, 2003.
34. Yoshimura A, Lien; E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D: Cutting edge: recognition of gram-positive cell wall components by the innate: immune system occurs via Toll-like receptor 2. J Immunol 163:1-5, 1999.
35. Peck OM, Fan H, Tempel GE, Teti G, Halushka PV, Cook JA: Staphylococcus aureus and lipopolysaccharide induce homologous tolerance but heterologous priming: role of interferon-gamma. Shock 21:254-260, 2004.
36. Medvedev AE, Flo T, Ingalls RR, Golenbock DT, Teti G, Vogel SN, Espevik T: Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls. J Immunol 160:4535-4542, 1998.