2-Chloro-2′-deoxyadenosine-induced apoptosis in T leukemia cells is mediated via a caspase-3-dependent mitochondrial feedback amplification loop

International Journal of Oncology

Volumn 32, Issue 6, 2008, Pages 1325-1333

  Conrad, David M ^a   Robichaud, Matthew R J ^a   Mader, Jamie S ^a   Boudreau, Robert T M ^a   Richardson, Angela M ^a   Giacomantonio, Carman A ^a   Hoskin, David W ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

2 chloro 2 deoxyadenosine; Apoptosis; Caspase; Leukemia; Mitochondria; p38 mitogen activated protein kinase

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CLADRIBINE; DEATH RECEPTOR; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BCL 2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; ANTINEOPLASTIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

APOPTOSIS; ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T CELL LEUKEMIA; DRUG EFFECT; METABOLISM; MITOCHONDRION; PATHOLOGY; PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CLADRIBINE; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; FEEDBACK, BIOCHEMICAL; HUMANS; JURKAT CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION;

EID: 48149085154     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo_32_6_1325     Document Type: Article

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