YM-341619 suppresses the differentiation of spleen T cells into Th2 cells in vitro, eosinophilia, and airway hyperresponsiveness in rat allergic models

European Journal of Pharmacology

Volumn 590, Issue 1-3, 2008, Pages 409-416

  Ohga, Keiko ^a   Kuromitsu, Sadao ^a   Takezawa, Ryuichi ^a   Numazaki, Mako ^a   Ishikawa, Jun ^a   Nagashima, Shinya ^a   Shimizu, Yasuaki ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Asthma; GATA 3; IL 4 (Interleukin 4); STAT6 (signal transducer and activator of transcription) 6; Th (T helper) 2 cell; YM 341619

Indexed keywords

2 [(4 MORPHOLIN 4 YLPHENYL)AMINO] 4 [(2,3,6 TRIFLUOROBENZYL)AMINO]PYRIMIDINE 5 CARBOXAMIDE; 2,4 DINITROPHENOL; ALLERGEN; ANTIASTHMATIC AGENT; CD28 ANTIGEN; CD3 ANTIBODY; CD4 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G2A; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 4; MESSENGER RNA; OVALBUMIN; PREDNISOLONE; STAT6 PROTEIN; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG; YM 341619;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASCARIS; ASTHMA; BRONCHUS HYPERREACTIVITY; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG DOSE COMPARISON; EOSINOPHIL; FEMALE; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IN VITRO STUDY; INTERFERON PRODUCTION; LOEFFLER PNEUMONIA; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; RAT; REPORTER GENE; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION; TH2 CELL;

ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; CELL DIFFERENTIATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EOSINOPHILIA; FEMALE; GATA3 TRANSCRIPTION FACTOR; INTERFERON TYPE II; INTERLEUKIN-4; MALE; MICE; MICE, INBRED C57BL; MORPHOLINES; PROMOTER REGIONS (GENETICS); PYRIMIDINES; RATS; RATS, INBRED BN; RATS, WISTAR; SPLEEN; STAT6 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; TH2 CELLS;

EID: 48049089594     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.06.035     Document Type: Article

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