The anergic state in sarcoidosis is associated with diminished dendritic cell function

Journal of Immunology

Volumn 181, Issue 1, 2008, Pages 746-755

  Mathew, Sneha ^a   Bauer, Kristy L ^a   Fischoeder, Arne ^b   Bhardwaj, Nina ^a   Oliver, Stephen J ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELLULAR IMMUNITY; CHRONIC INFLAMMATION; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DENDRITIC CELL; GRANULOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SARCOIDOSIS; T LYMPHOCYTE; ADULT; AGED; BIOPSY; BIOSYNTHESIS; BLOOD CELL COUNT; BONE MARROW CELL; CANDIDA; CELL CULTURE; CELL DIFFERENTIATION; DRUG EFFECT; FEMALE; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; MIXED LYMPHOCYTE CULTURE; PATHOLOGY;

BIOLOGICAL MARKER; CARBOXYPHENYLGLYCINE; CYTOKINE; DRUG DERIVATIVE; GLYCINE; PLASMA PROTEIN;

ADULT; AGED; BIOLOGICAL MARKERS; BIOPSY; BLOOD CELL COUNT; BLOOD PROTEINS; CANDIDA; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; FEMALE; GLYCINE; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNE TOLERANCE; LYMPHOCYTE CULTURE TEST, MIXED; MALE; MIDDLE AGED; MYELOID CELLS; SARCOIDOSIS;

EID: 47949128207     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.1.746     Document Type: Article

References (59)

1. Iannuzzi, M. C., B. A. Rybicki, and A. S. Teirstcin. 2007. Sarcoidosis. N. Engl. J. Med. 357: 2153-2165.
2. Judson, M. A. 2003. The etiologic agent of sarcoidosis: what if there isn't one? Chest 124: 6-8.
3. Reich, J. M. 2003. What is sarcoidosis? Chest 124: 367-371.
4. Friou, G. J. 1952. A study of the cutaneous reactions to oidiomycin, trichophytin and mumps skin test antigens in patients with sarcoidosis. Yale J. Biol. Med. 24: 533-539.
5. Sones, M., and H. L. Israel. 1954. Altered immunological reactions in sarcoidosis. Ann. Intern, Med. 40: 260-268.
6. Jones, J. V. 1967. Development of sensitivity to dinitrochlorobenzene in patients with sarcoidosis. Clin. Exp. Immunol. 2: 477-487.
7. Bertran, G., E. Arzt, E. Resnik, C. Mosca, and V. Nahmod. 1992. Inhibition of interferon gamma production by peripheral blood mononuclear leukocytes of patients with sarcoidosis: pathogenic implications. Chest 101: 996-999.
8. Daniele, R. P., J. H. Dauber, and M. D. Rossman. 1980. Immunologic abnormalities in sarcoidosis. Ann. Intern Med. 92: 406-416.
9. Goodwin, J. S., R. DeHoratius, H. Israel, G. T. Peake, and R. P. Messner. 1979. Suppressor cell function in sarcoidosis. Ann. Intern. Med. 90: 169-173.
10. Banchereau, J., F. Briere, C. Caux, J. Davoust, S. Lebecque, Y. J. Liu, B. Pulendran, and K. Palucka. 2000. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18: 767-811.
11. Gabrilovich, D. I., H. L. Chen, K. R. Girgis, H. T. Cunningham, G. M. Meny, S. Nadaf, D. Kavanaugh, and D. P. Carbone. 1996. Production of vascular en-dothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat. Med. 2: 1096-1103.
12. Granelli-Piperno, A., A. Golebiowska, C. Trumpfheller, F. P. Siegal, and R. M. Steinman. 2004. HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation. Proc. Natl. Acad. Sci. USA 101: 7669-7674.
13. Mariotti, S., R. Teloni, E. lona, L. Fattorini, F. Giannoni, G. Romagnoli, G. Orefici, and R. Nisini. 2002. Mycobacterium tuberculosis subverts the differentiation of human monocytes into dendritic cells. Eur. J. Immunol. 32: 3050-3058.
14. Ratta, M., F. Fagnoni, A. Curti, R. Vescovini, P. Sansoni, B. Oliviero, M. Fogli, E. Ferri, G. R. Delia Cuna, S. Tura, et al. 2002. Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6. Blood 100: 230-237.
15. Satthapom, S., A. Robins, W. Vassanasiri, M. El-Sheemy, J. A. Jibril, D. Clark, D. Valerio, and O. Eremin. 2004. Dendritic cells are dysfunctional in patients with operable breast cancer. Cancer Immunol. Immunother. 53: 510-518.
16. Urban, B. C, D. J. Ferguson, A. Pain, N. Willcox, M. Plebanski, J. M. Austyn, and D. J. Roberts. 1999. Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells. Nature 400: 73-77.
17. American Thoracic Society. 1999. Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS), and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am. J. Respir. Crit. Care Med. 160: 736-755.
18. Krug, A., S. Rothenfusser, V. Homung, B. Jahrsdorfer, S. Blackwell, Z. K. Ballas, S. Endres, A. M. Krieg, and G. Hartmann. 2001. Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacyloid dendritic cells. Eur. J. Immunol. 31: 2154-2163.
19. Chang, H. M., T. Y. Shann, K. T. Mok, W. Y. Lui, F. K. P'Eng, and H. Y. Lin. 1989. Multitest skin testing values of cell-mediated immunity among healthy individuals in Taiwan. Zhonghua Yi Xue Za Zhi 44: 81-88.
20. Hickie, C,. I. Hickie, D. Silove, D. Wakefield, and A. Lloyd. 1995. Delayed-type hyperscnsitivity skin testing: normal values in the Australian population. Int. J. Immunophannacol. 17: 629-634.
21. Maxwell, A. P., and D. R. McCluskey. 1986. Assessment of cell-mediated immunity in a British population using multiple skin test antigens. Clin. Allergy 16: 365-369.
22. Turiaf, J., M. Menault, and J. P. Battesti. 1970. Recherches sur les manisfesta-tions immunologiques de la sarcoidose. Ann. Med. Interne 121: 117-134.
23. Miyara, M., Z. Amoura, C. Parizot, C. Badoual, K. Dorgham, S. Trad (text missprint here) et. al. 2006. The immune paradox of sarcoidosis and regulatory T cells. J. Exp. Med. 203: 359-370.
24. Oliver, S. J., T. Kikuchi, J. G. Krueger, and G. Kaplan. 2002. Thalidomide induces granuloma differentiation in sarcoid skin lesions associated with disease improvement. Clin. Immunol. 102: 225-236.
25. + subset. J. Exp. Med. 187: 1885-1892.
26. Mohty, M., A. M. Stoppa, D. Blaise, D. Isnardon, J. A. Gastaut, D. Olive, and B. Gaugler. 2002. Differential regulation of dendritic cell function by the immu-nomodulatory drug thalidomide. J. Leukocyte Biol. 72: 939-945.
27. Munro, C. S., D. A. Campbell, R. M. Du Bois, D. N. Mitchell, P. J. Cole, and L. W. Poulter. 1987. Dendritic cells in cutaneous, lymph node and pulmonary lesions of sarcoidosis. Scand. J. Immunol. 25: 461-467.
28. Fox, J. L., B. Berman, A. S. Teirstein, D. S. France, and M. L. Reed. 1983. Quantitation of cutaneous Langerhans cells of sarcoidosis patients. J. Invest. Der-matol. 80: 472-475.
29. Havenith, C. E., J. M. van Haarst, A. J. Brecdijk, M. G. Betjcs, H. C. Hoogsteden, R. H. Bcelen, and E. C. Hoefsmit. 1994. Enrichment and characterization of dendritic cells from human bronchoalveolar lavages. Clin. Exp. Immunol. 96: 339-343.
30. Lommatzsch, M., K. Bratke, A. Bier, P. Julius, M. Kucpper, \V. Luttmann, and J. C. Virchow. 2007. Airway dendritic cell phenolypes in inflammatory diseases of the human lung. Eur. Respir. J. 30: 878-886.
31. Ota, M., R. Amakawa, K. Uchira, T. Ito, Y. Yagi, A. Oshiro, Y. Date, H. Oyaizu, T. Shigeki, Y. Ozaki, et al. 2004. Involvement of dendritic cells in sarcoidosis. Thorax 59: 408-413.
32. Nigou, J., C. Zellc-Rieser, M. Gilleron, M. Thurnher, and G. Puzo. 2001. Man-nosylated lipoarabinomannans inhibit 1L-12 production by human dendritic cells: evidence for a negative signal delivered through the mannose receptor. J. Immunol. 166: 7477-7485.
33. Stenger, S., K. R. Niazi, and R. L. Modlin. 1998. Down-regulation of CD1 on antigen-presenting cells by infection with Mycobacterium tuberculosis. J. Immunol. 161:3582-3588.
34. Sharma, S., M. Stolina, S. C. Yang, F. Baratclli, J. F. Lin, K. Atianzar, J. Luo, L. Zhu, Y. Lin, M. Huang, et al. 2003. Tumor cyclooxygenase 2-dependent suppression of dendritic cell function. Clin. Cancer Res. 9: 961-968.
35. + anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity. Blood 99: 2468-2476.
36. Yang, L., and D. P. Carbone. 2004. Tumor-host immune interactions and dendritic cell dysfunction. Adv. Cancer Res. 92: 13-27.
37. Langenkamp, A., M. Messi, A. Lanzavecchia, and F. Sallusto. 2000. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat. Immunol. 1: 311-316.
38. Ormandy, L. A., A. Farber, T. Cantz, S. Petrykowska, H. Wedemeyer, M. Horning, F. Lehner, M. P. Manns, F. Korangy, and T. F. Greten. 2006. Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma. World J. Gastroenterol. 12: 3275-3282.
39. Delia Bella, S., M. Gennaro, M. Vaccari, C. Ferraris, S. Nicola, A. Riva, M. Clerici, M. Greco, and M. L. Villa. 2003. Altered maturation of peripheral blood dendritic cells in patients with breast cancer. Br. J. Cancer 89: 1463-1472.
40. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170: 827-845.
41. Ma, X., J. M. Chow, G. Gri, G. Carra, F. Gerosa, S. F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J. Exp. Med. 183: 147-157.
42. Sieburth, D., E. W. Jabs, J. A. Warrington, X. Li, J. Lasota, S. LaForgia, K. Kelleher, K. Hucbner, J. J. Wasmuth, and S. F. Wolf. 1992. Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. Genomics 14: 59-62.
43. Barbarin, V., M. Petrek, V. Kolek, J. Van Snick, F. Huaux, and D. Lison. 2003. Characterization of p40 and IL-10 in the BALF of patients with sarcoidosis. J. Interferon Cytokine Res. 23: 449-456.
44. Hata, M., K. Sugisaki, E. Miyazaki, T. Kumamoto, and T. Tsuda. 2007. Circulating IL-12 p40 ís increased in the patients with sarcoidosis, correlation with clinical markers. Intern. Med. 46: 1387-1393.
45. Shigehara, K., N. Shijubo, M. Ohmichi, K. Kamiguchi, R. Takahashi, S. Morita-Ichimura, T. Ohchi, T. Tatsuno, Y. Hiraga, S. Abe, and N. Sato. 2003. Increased circulating interleukin-12 (IL-12) p40 in pulmonary sarcoidosis. Clin. Exp. Immunol. 132: 152-157.
46. Mattner, F., S. Fishcer, S. Guckes, S. Jin, H. Kaulen, E. Schmitt, E. Rude, and T. Germann. 1993. The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur. J. Immunol. 23: 2202-2208.
47. Nigg, A. P., S. Zahn, D. Ruckeri, C. Holscher, T. Yoshimoto, J. M. Ehrchen, F. Wolbing, M. C. Udey, and E. von Stebut. 2007. Dendritic cell-derived IL-12p40 homodimer contributes to susceptibility in cutaneous leishmaniasis in BALB/c mice. J. Immunol. 178: 7251-7258.
48. Inui, N., K. Chida, T. Suda, and H. Nakamura. 2001. TH1/TH2 and TC1/TC2 profiles in peripheral blood and bronchoalveolar lavage fluid cells in pulmonary sarcoidosis. J. Allergy Clin. Immunol. 107: 337-344.
49. + T cells. Clin. Exp. Immunol. 122: 241-248.
50. Shigehara, K., N. Shijubo, M. Ohmichi, S. Kon, Y. Shibuya, R. Takahashi, S. Morita-Ichimura, T. Tatsuno, Y. Hiraga, S. Abe, and N. Sato. 2000. Enhanced mRNA expression of Thl cytokines and IL-12 in active pulmonary sarcoidosis. Sarcoidosis Vasc. Diffuse Lung Dis. 17: 151-157.
51. + lung and blood T cells in sarcoidosis. Am. J. Respir. Crit. Care Med. 163: 115-121.
52. Cook, G., J. D. Campbell, C. E. Carr, K. S. Boyd, and I. M. Franklin. 1999. Transforming growth factor β from multiple myeloma cells inhibits proliferation and IL-2 responsiveness in T lymphocytes. J. Leukocyte Biol. 66: 981-988.
53. Orsini, E., A. Guarini, S. Chiaretti, F. R. Mauro, and R. Foa. 2003. The circulating dendritic cell compartment in patients with chronic lymphocytic leukemia is severely defective and unable to stimulate an effective T-cell response. Cancer Res. 63: 4497-4506.
54. O'Doherty, U., M. Peng, S. Gezelter, W. J. Swiggard, M. Betjes, N. Bhardwaj, and R. M. Steinman. 1994. Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. Immunology 82: 487-493.
55. Reis e Sousa, C. 2006. Dendritic cells in a mature age. Nat. Rev. Immunol. 6: 476-483.
56. Chen, L., Z. Zhang, W. Chen, Z. Zhang, Y. Li, M. Shi, J. Zhang, L. Chen, S. Wang, and F. S. Wang. 2007. B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B. J. Immunol. 178: 6634-6641.
57. Curiel, T. J., S. Wei, H. Dong, X. Alvarez, P. Cheng, P. Mottram, R. Krzysiek, K. L. Knutson, B. Daniel, M. C. Zimmermann, et al. 2003. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat. Med. 9: 562-567.
58. Kuwana, M. 2002. Induction of anergic and regulatory T cells by plasmacytoid dendritic cells and other dendritic cell subsets. Hum. Immunol. 63: 1156-1163.
59. Leclerc, S., R. P. Myers, J. Moussalli, S. Herson, T. Poynard, and O. Benveniste. 2003. Sarcoidosis and interferon therapy: report of five cases and review of the literature. Eur. J. Intern. Med. 14: 237-243.