Solid-phase extraction followed by purification with tri-n-butylphosphate as a simple and useful rat plasma clean-up method for HPLC-UV determination of zonampanel monohydrate (YM872), a highly water-soluble α-amino-3-hydroxy- 5-methylisoxazole-4-propionic acid receptor antagonist

Journal of Liquid Chromatography and Related Technologies

Volumn 31, Issue 7, 2008, Pages 1072-1080

  Noguchi, Kiyoshi ^a   Miyashita, Aiji ^a   Hashimoto, Tadashi ^a   Aoki, Toshiko ^a   Soeishi, Yoshiaki ^a   Kamimura, Hidetaka ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

AMPA Receptor antagonist; HPLC; Plasma; UV detection; YM872; Zonampanel monohydrate

Indexed keywords

AMPA RECEPTOR ANTAGONIST; PLASMA CONCENTRATIONS; UV DETECTION; ZONAMPANEL MONOHYDRATE;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RATS;

BIOTECHNOLOGY;

[1,2,3,4 TETRAHYDRO 7 (1H IMIDAZOL 1 YL) 6 NITRO 2,3 DIOXO 1 QUINOXALINYL]ACETIC ACID; AMPA RECEPTOR ANTAGONIST; PHOSPHORIC ACID DERIVATIVE; TRI N BUTYLPHOSPHATE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; DRUG DETERMINATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PLASMA; PURIFICATION; RAT; SOLID PHASE EXTRACTION; ULTRAVIOLET RADIATION;

RATTUS;

EID: 39749187172     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070801925607     Document Type: Article

References (8)