Identification of metabolites of [14C]zonampanel, an α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist, following intravenous infusion in healthy volunteers

Xenobiotica

Volumn 35, Issue 4, 2005, Pages 359-371

  Minematsu, T ^a   Sohda, K Y ^a   Hashimoto, T ^a   Imai, H ^a   Usui, T ^a   Kamimura, H ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Excretion; Human; Metabolism; Pharmacokinetics; Renal secretion; Zonampanel

Indexed keywords

6 (1 IMIDAZOLYL) 7 NITRO 2,3 QUINOXALINEDIONE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; [1,2,3,4 TETRAHYDRO 7 (1H IMIDAZOL 1 YL) 6 NITRO 2,3 DIOXO 1 QUINOXALINYL]ACETIC ACID; AMPA RECEPTOR ANTAGONIST; DRUG METABOLITE; UNCLASSIFIED DRUG; ZONAMPANEL; AMPA RECEPTOR; CARBON; IMIDAZOLE DERIVATIVE; QUINOXALINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG RECEPTOR BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; KIDNEY CLEARANCE; KIDNEY TUBULE EXCRETION; MALE; NONHUMAN; NORMAL HUMAN; OPEN STUDY; RADIOMETRY; RAT; REDUCTION KINETICS; STEADY STATE; URINALYSIS; URINE LEVEL; XENOBIOTIC METABOLISM; ADOLESCENT; ADULT; DRUG ANTAGONISM; INTRAVENOUS DRUG ADMINISTRATION;

ADOLESCENT; ADULT; CARBON RADIOISOTOPES; HUMANS; IMIDAZOLES; INJECTIONS, INTRAVENOUS; MALE; QUINOXALINES; RECEPTORS, AMPA;

EID: 20944431546     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250500066220     Document Type: Article

References (13)

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