-
1
-
-
1642288430
-
-
Available at
-
World Health Organization. Hepatitis C fact sheet. Available at: http://www.who.int/vaccine_research/diseases/viral_cancers/en/index2.html
-
Hepatitis C fact sheet
-
-
-
2
-
-
0036828783
-
Course and outcome of hepatitis C
-
Hoofnagle JH. Course and outcome of hepatitis C. Hepatology 2002; 36:s21-s29.
-
(2002)
Hepatology
, vol.36
-
-
Hoofnagle, J.H.1
-
5
-
-
7444256169
-
Genetic diversity and evolution of hepatitis C virus - 15 years on
-
Simmonds P. Genetic diversity and evolution of hepatitis C virus - 15 years on. J Gen Virol 2004; 85:3173-3188.
-
(2004)
J Gen Virol
, vol.85
, pp. 3173-3188
-
-
Simmonds, P.1
-
6
-
-
0027414062
-
Characterization of the hepatitis C virus-encoded serine proteinase: Determination of proteinase-dependent polyprotein cleavage sites
-
Grakoui A, McCourt DW, Wychowski C, Feinstone SM, Rice CM. Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites. J Virol 1993; 67:2832-2843.
-
(1993)
J Virol
, vol.67
, pp. 2832-2843
-
-
Grakoui, A.1
McCourt, D.W.2
Wychowski, C.3
Feinstone, S.M.4
Rice, C.M.5
-
7
-
-
0344201903
-
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
-
Lamarre D, Anderson PC, Bailey M, et al. An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature 2003; 426:186-189.
-
(2003)
Nature
, vol.426
, pp. 186-189
-
-
Lamarre, D.1
Anderson, P.C.2
Bailey, M.3
-
8
-
-
7644232426
-
Short-term antiviral efficacy of BILN-2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients
-
Hinrichsen H, Benhamou Y, Wedemeyer H, et al. Short-term antiviral efficacy of BILN-2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients. Gastroenterology 2004; 127:1347-1355.
-
(2004)
Gastroenterology
, vol.127
, pp. 1347-1355
-
-
Hinrichsen, H.1
Benhamou, Y.2
Wedemeyer, H.3
-
9
-
-
33646446894
-
VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCV replicon cells
-
Lin K, Perni RB, Kwong AD, Lin C. VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCV replicon cells. Antimicrob Agents Chemother 2006; 50:1813-1822.
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 1813-1822
-
-
Lin, K.1
Perni, R.B.2
Kwong, A.D.3
Lin, C.4
-
10
-
-
33846421758
-
28 Days of the hepatitis C protease inhibitor VX-950, in combination with PEG-interferon- α-2a and ribavirin, is well-tolerated and demonstrates robust antiviral effects
-
Lawitz E, Rodriguez-Torres M, Muir AJ, et al. 28 Days of the hepatitis C protease inhibitor VX-950, in combination with PEG-interferon- α-2a and ribavirin, is well-tolerated and demonstrates robust antiviral effects. Gastroenterology 2006; 131:950-951.
-
(2006)
Gastroenterology
, vol.131
, pp. 950-951
-
-
Lawitz, E.1
Rodriguez-Torres, M.2
Muir, A.J.3
-
11
-
-
33644639990
-
SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells
-
Malcolm BA, Liu R, Lahser F, et al. SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells. Antimicrob Agents Chemother 2006; 50:1013-1020.
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 1013-1020
-
-
Malcolm, B.A.1
Liu, R.2
Lahser, F.3
-
12
-
-
33646449468
-
Discovery of SCH446211 (SCH-6): A new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication
-
Bogen SL, Arasappan A, Bennett F, et al. Discovery of SCH446211 (SCH-6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication. J Med Chem 2006; 49:2750-2757.
-
(2006)
J Med Chem
, vol.49
, pp. 2750-2757
-
-
Bogen, S.L.1
Arasappan, A.2
Bennett, F.3
-
13
-
-
33845907356
-
In vitro antiviral activity of SCH446211 (SCH-6), a novel inhibitor of the hepatitis C virus NS3 serine protease
-
Liu R, Abid K, Pichardo J, Pazienza V, et al. In vitro antiviral activity of SCH446211 (SCH-6), a novel inhibitor of the hepatitis C virus NS3 serine protease. J Antimicrob Chemother 2007; 59:51-58.
-
(2007)
J Antimicrob Chemother
, vol.59
, pp. 51-58
-
-
Liu, R.1
Abid, K.2
Pichardo, J.3
Pazienza, V.4
-
14
-
-
34249081116
-
-
Prongay AJ, Guo Z, Yao N, et al. Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3- dioxopropyl]-3-[2(S)-[[[(1,1-dimethy lethyl)amino]carbonyl]amino]-3,3- dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S) -carboxamide (Sch 503034) II. Key steps in structure-based optimization. J Med Chem 2007; 50:2310-2318.
-
Prongay AJ, Guo Z, Yao N, et al. Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3- dioxopropyl]-3-[2(S)-[[[(1,1-dimethy lethyl)amino]carbonyl]amino]-3,3- dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S) -carboxamide (Sch 503034) II. Key steps in structure-based optimization. J Med Chem 2007; 50:2310-2318.
-
-
-
-
15
-
-
46949111215
-
Preclinical characteristics of ITMN-B, an orally active inhibitor of the HCV NS3/4A protease nominated for preclinical development
-
Seiwert SD, Andrews SW, Tan H, et al. Preclinical characteristics of ITMN-B, an orally active inhibitor of the HCV NS3/4A protease nominated for preclinical development. J Hepatol 2006; 44:S278.
-
(2006)
J Hepatol
, vol.44
-
-
Seiwert, S.D.1
Andrews, S.W.2
Tan, H.3
-
16
-
-
9644275435
-
Combination of a hepatitis C virus NS3-NS4A protease inhibitor and alpha interferon synergistically inhibits viral RNA replication and facilitates viral RNA clearance in replicon cells
-
Lin K, Kwong AD, Lin C. Combination of a hepatitis C virus NS3-NS4A protease inhibitor and alpha interferon synergistically inhibits viral RNA replication and facilitates viral RNA clearance in replicon cells. Antimicrob Agents Chemother 2004; 48:4784-4792.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 4784-4792
-
-
Lin, K.1
Kwong, A.D.2
Lin, C.3
-
17
-
-
47649095813
-
28 Days of the hepatitis C protease inhibitor VX-950, in combination with PEG-interferon-α-2a and Ribavirin, is well-tolerated and demonstrates robust antiviral effects
-
Abstract DDW
-
McHutchison JG. 28 Days of the hepatitis C protease inhibitor VX-950, in combination with PEG-interferon-α-2a and Ribavirin, is well-tolerated and demonstrates robust antiviral effects. Gastroenterology 2006; 131:250. Abstract DDW 2006.
-
(2006)
Gastroenterology
, vol.2006
, Issue.131
, pp. 250
-
-
McHutchison, J.G.1
-
18
-
-
34247205808
-
SCH 503034, a novel hepatitis C virus protease inhibitor, plus pegylated interferon alpha-2b for genotype 1 nonresponders
-
Sarrazin C, Rouzier R, Wagner F, et al. SCH 503034, a novel hepatitis C virus protease inhibitor, plus pegylated interferon alpha-2b for genotype 1 nonresponders. Gastroenterology 2007; 132:1270-1278.
-
(2007)
Gastroenterology
, vol.132
, pp. 1270-1278
-
-
Sarrazin, C.1
Rouzier, R.2
Wagner, F.3
-
19
-
-
0037687422
-
Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
-
Foy E, Li K, Wang C, et al. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science 2003; 300:1145-1148.
-
(2003)
Science
, vol.300
, pp. 1145-1148
-
-
Foy, E.1
Li, K.2
Wang, C.3
-
20
-
-
14544280209
-
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
-
Li K, Foy E, Ferreon JC, et al. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A 2005; 102:2992-2997.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 2992-2997
-
-
Li, K.1
Foy, E.2
Ferreon, J.C.3
-
21
-
-
0028943992
-
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
-
Condra JH, Schleif WA, Blahy OM, et al. In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature 1995; 374:569-571.
-
(1995)
Nature
, vol.374
, pp. 569-571
-
-
Condra, J.H.1
Schleif, W.A.2
Blahy, O.M.3
-
22
-
-
0037333918
-
In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor
-
Trozzi C, Bartholomew L, Ceccacci A, et al. In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor. J Virol 2003; 77:3669-3679.
-
(2003)
J Virol
, vol.77
, pp. 3669-3679
-
-
Trozzi, C.1
Bartholomew, L.2
Ceccacci, A.3
-
23
-
-
2542467813
-
Mutations conferring resistance to a potent hepatitis C virus serine protease inhibitor in vitro
-
Lu L, Pilot-Matias TJ, Stewart KD, et al. Mutations conferring resistance to a potent hepatitis C virus serine protease inhibitor in vitro. Antimicrob Agents Chemother 2004; 48:2260-2266.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 2260-2266
-
-
Lu, L.1
Pilot-Matias, T.J.2
Stewart, K.D.3
-
24
-
-
2342420348
-
In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN-2061: Structural analysis indicates different resistance mechanisms
-
Lin C, Lin K, Luong YP, et al. In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN-2061: structural analysis indicates different resistance mechanisms. J Biol Chem 2004; 279:17508-17514.
-
(2004)
J Biol Chem
, vol.279
, pp. 17508-17514
-
-
Lin, C.1
Lin, K.2
Luong, Y.P.3
-
25
-
-
27744529265
-
In vitro studies of cross-resistance mutations against two hepatitis C virus serine protease inhibitors, VX-950 and BILN-2061
-
Lin C, Gates CA, Rao BG, et al. In vitro studies of cross-resistance mutations against two hepatitis C virus serine protease inhibitors, VX-950 and BILN-2061. J Biol Chem 2005; 280:36784- 36791.
-
(2005)
J Biol Chem
, vol.280
, pp. 36784-36791
-
-
Lin, C.1
Gates, C.A.2
Rao, B.G.3
-
26
-
-
25844466713
-
Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro
-
Mo H, Lu L, Pilot-Matias T, et al. Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro. Antimicrob Agents Chemother 2005; 49:4305-4314.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 4305-4314
-
-
Mo, H.1
Lu, L.2
Pilot-Matias, T.3
-
27
-
-
33646369669
-
Mutations conferring resistance to SCH-6, a novel hepatitis C virus NS3/4A protease inhibitor: Reduced RNA replication fitness and partial rescue by second-site mutations
-
Yi M, Tong X, Skelton A, et al. Mutations conferring resistance to SCH-6, a novel hepatitis C virus NS3/4A protease inhibitor: reduced RNA replication fitness and partial rescue by second-site mutations. J Biol Chem 2006; 281:8205-8215.
-
(2006)
J Biol Chem
, vol.281
, pp. 8205-8215
-
-
Yi, M.1
Tong, X.2
Skelton, A.3
-
28
-
-
34547954645
-
In vitro synergistic antiviral activity of ITMN-191
-
Abstract 52
-
Seiwert S, Hong J, Lim S, et al. In vitro synergistic antiviral activity of ITMN-191. Rev Antiviral Ther 2007; 1:56. Abstract 52.
-
(2007)
Rev Antiviral Ther
, vol.1
, pp. 56
-
-
Seiwert, S.1
Hong, J.2
Lim, S.3
-
29
-
-
34547927078
-
Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: Sensitivity to telaprevir (VX-950) and interferon alpha
-
Zhou Y, Muh U, Hanzelka BL, et al. Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha. J Biol Chem 2007; 282:22619-22628.
-
(2007)
J Biol Chem
, vol.282
, pp. 22619-22628
-
-
Zhou, Y.1
Muh, U.2
Hanzelka, B.L.3
-
30
-
-
33750733159
-
The HCV NS3 protease inhibitor SCH 503034 in combination with Peg-IFN alpha-2b in the treatment of HCV-1 Peg-IFN alpha-2b nonresponders: Antiviral activity and HCV variant analysis
-
Zeuzem S, Sarrazin C, Wagner F, et al. The HCV NS3 protease inhibitor SCH 503034 in combination with Peg-IFN alpha-2b in the treatment of HCV-1 Peg-IFN alpha-2b nonresponders: antiviral activity and HCV variant analysis. J Hepatology 2006; 44:S35.
-
(2006)
J Hepatology
, vol.44
-
-
Zeuzem, S.1
Sarrazin, C.2
Wagner, F.3
-
31
-
-
34247594930
-
Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
-
Sarrazin C, Kieffer TL, Bartels D, et al. Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir. Gastroenterology 2007; 132:1767-1777.
-
(2007)
Gastroenterology
, vol.132
, pp. 1767-1777
-
-
Sarrazin, C.1
Kieffer, T.L.2
Bartels, D.3
-
32
-
-
3142700044
-
-
Thibeault D, Bousquet C, Gingras R, et al. Sensitivity of NS3 serine proteases from hepatitis C virus genotypes 2 and 3 to the inhibitor BILN-2061 10.1128/JVI.78.14.7352-7359.2004. J Virol 2004; 78:7352-7359.
-
Thibeault D, Bousquet C, Gingras R, et al. Sensitivity of NS3 serine proteases from hepatitis C virus genotypes 2 and 3 to the inhibitor BILN-2061 10.1128/JVI.78.14.7352-7359.2004. J Virol 2004; 78:7352-7359.
-
-
-
-
33
-
-
20144387727
-
Antiviral efficacy of NS3-serine protease inhibitor BILN-2061 in patients with chronic genotype 2 and 3 hepatitis C
-
Reiser M, Hinrichsen H, Benhamou Y, et al. Antiviral efficacy of NS3-serine protease inhibitor BILN-2061 in patients with chronic genotype 2 and 3 hepatitis C. Hepatology 2005; 41:832-835.
-
(2005)
Hepatology
, vol.41
, pp. 832-835
-
-
Reiser, M.1
Hinrichsen, H.2
Benhamou, Y.3
-
34
-
-
0035983243
-
Genetic diversity and response to IFN of the NS3 protease gene from clinical strains of the hepatitis C virus
-
Holland-Staley CA, Kovari LC, Golenberg EM, Pobursky KJ, Mayers DL. Genetic diversity and response to IFN of the NS3 protease gene from clinical strains of the hepatitis C virus. Arch Virol 2002; 147:1385-1406.
-
(2002)
Arch Virol
, vol.147
, pp. 1385-1406
-
-
Holland-Staley, C.A.1
Kovari, L.C.2
Golenberg, E.M.3
Pobursky, K.J.4
Mayers, D.L.5
-
35
-
-
0141615978
-
Sequence analysis of NS3 protease gene in clinical strains of hepatitis C virus
-
Lodrini S, Bagaglio S, Canducci F, et al. Sequence analysis of NS3 protease gene in clinical strains of hepatitis C virus. J Biol Regul Homeost Agents 2003; 17:198-204.
-
(2003)
J Biol Regul Homeost Agents
, vol.17
, pp. 198-204
-
-
Lodrini, S.1
Bagaglio, S.2
Canducci, F.3
-
36
-
-
13144290646
-
Genetic heterogeneity of the NS3 protease gene in hepatitis C virus genotype 1 from untreated infected patients
-
Vallet S, Gouriou S, Nousbaum JB, Legrand-Quillien MC, Goudeau A, Picard B. Genetic heterogeneity of the NS3 protease gene in hepatitis C virus genotype 1 from untreated infected patients. J Med Virol 2005; 75:528-537.
-
(2005)
J Med Virol
, vol.75
, pp. 528-537
-
-
Vallet, S.1
Gouriou, S.2
Nousbaum, J.B.3
Legrand-Quillien, M.C.4
Goudeau, A.5
Picard, B.6
-
37
-
-
33645101203
-
Genetic similarity of hepatitis C virus and fibrosis progression in chronic and recurrent infection after liver transplantation
-
López-Labrador FX, Bracho MA, Berenguer M, et al. Genetic similarity of hepatitis C virus and fibrosis progression in chronic and recurrent infection after liver transplantation. J Viral Hepat 2006; 13:104-115.
-
(2006)
J Viral Hepat
, vol.13
, pp. 104-115
-
-
López-Labrador, F.X.1
Bracho, M.A.2
Berenguer, M.3
-
38
-
-
25844523297
-
Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes
-
Simmonds P, Bukh J, Combet C, et al. Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes. Hepatology 2005; 42:962-973.
-
(2005)
Hepatology
, vol.42
, pp. 962-973
-
-
Simmonds, P.1
Bukh, J.2
Combet, C.3
-
39
-
-
0027968068
-
CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
-
Thompson JD, Higgins DG, Gibson TJ. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 1994; 22:4673-4680.
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 4673-4680
-
-
Thompson, J.D.1
Higgins, D.G.2
Gibson, T.J.3
-
40
-
-
34547781750
-
-
Tamura K, Dudley J, Nei M, Kumar S. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol 2007; 24:1596-1599
-
Tamura K, Dudley J, Nei M, Kumar S. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol 2007; 24:1596-1599.
-
-
-
-
41
-
-
47649107081
-
-
Hall TA. Bioedit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. In Nucleic Acids Symposium Series 1999; 41:95-98.
-
Hall TA. Bioedit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. In Nucleic Acids Symposium Series 1999; 41:95-98.
-
-
-
-
42
-
-
0034848170
-
DAMBE: Software package for data analysis in molecular biology and evolution
-
Xia X, Xie Z. DAMBE: software package for data analysis in molecular biology and evolution. J Hered 2001; 92:371-373.
-
(2001)
J Hered
, vol.92
, pp. 371-373
-
-
Xia, X.1
Xie, Z.2
-
44
-
-
0026739607
-
Signature pattern analysis: A method for assessing viral sequence relatedness
-
Korber B, Myers G. Signature pattern analysis: a method for assessing viral sequence relatedness. AIDS Res Hum Retroviruses 1992; 8:1549-1560.
-
(1992)
AIDS Res Hum Retroviruses
, vol.8
, pp. 1549-1560
-
-
Korber, B.1
Myers, G.2
-
45
-
-
33646036163
-
Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034
-
Tong X, Chase R, Skelton A, Chen T, Wright-Minogue J, Malcolm BA. Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034. Antiviral Res 2006; 70:28-38.
-
(2006)
Antiviral Res
, vol.70
, pp. 28-38
-
-
Tong, X.1
Chase, R.2
Skelton, A.3
Chen, T.4
Wright-Minogue, J.5
Malcolm, B.A.6
-
46
-
-
36248939229
-
Sequence variation of NS3/4A in HCV replicons exposed to ITMN-191 concentrations encompassing those lilkely to be achieved following clinical dosing
-
Seiwert SD, Hon J, Lim SR, Wang T, Tan H, Blatt LM. Sequence variation of NS3/4A in HCV replicons exposed to ITMN-191 concentrations encompassing those lilkely to be achieved following clinical dosing. J Hepatol 2007; 46:S244-S245.
-
(2007)
J Hepatol
, vol.46
-
-
Seiwert, S.D.1
Hon, J.2
Lim, S.R.3
Wang, T.4
Tan, H.5
Blatt, L.M.6
-
47
-
-
0032889528
-
Selection of functional variants of the NS3-NS4A protease of hepatitis C virus by using chimeric Sindbis viruses
-
Filocamo G, Pacini L, Nardi C, et al. Selection of functional variants of the NS3-NS4A protease of hepatitis C virus by using chimeric Sindbis viruses. J Virol 1999; 73:561-575.
-
(1999)
J Virol
, vol.73
, pp. 561-575
-
-
Filocamo, G.1
Pacini, L.2
Nardi, C.3
-
48
-
-
0035342440
-
Effect of naturally occurring active site mutations on hepatitis C virus NS3 protease specificity
-
Beyer BM, Zhang R, Hong Z, Madison V, Malcolm BA. Effect of naturally occurring active site mutations on hepatitis C virus NS3 protease specificity. Proteins 2001; 43:82-88.
-
(2001)
Proteins
, vol.43
, pp. 82-88
-
-
Beyer, B.M.1
Zhang, R.2
Hong, Z.3
Madison, V.4
Malcolm, B.A.5
-
49
-
-
32244436044
-
Impact of naturally occurring variants of HCV protease on the binding of different classes of protease inhibitors
-
Tong X, Guo Z, Wright-Minogue J, et al. Impact of naturally occurring variants of HCV protease on the binding of different classes of protease inhibitors. Biochemistry 2006; 45:1353-1361.
-
(2006)
Biochemistry
, vol.45
, pp. 1353-1361
-
-
Tong, X.1
Guo, Z.2
Wright-Minogue, J.3
-
50
-
-
33846417968
-
Persistence of HIV-1 variants with multiple protease inhibitor (PI)-resistance mutations in the absence of PI therapy can be explained by compensatory fixation
-
van Maarseveen NM, Wensing AMJ, Jong D, et al. Persistence of HIV-1 variants with multiple protease inhibitor (PI)-resistance mutations in the absence of PI therapy can be explained by compensatory fixation. J Infect Dis 2007; 195:399-409.
-
(2007)
J Infect Dis
, vol.195
, pp. 399-409
-
-
van Maarseveen, N.M.1
Wensing, A.M.J.2
Jong, D.3
-
51
-
-
33645785349
-
Hepatitis C virus protease gene diversity in patients coinfected with human immunodeficiency virus
-
Winters MA, Welles SL, Holodniy M. Hepatitis C virus protease gene diversity in patients coinfected with human immunodeficiency virus. J Virol 2006; 80:4196-4199.
-
(2006)
J Virol
, vol.80
, pp. 4196-4199
-
-
Winters, M.A.1
Welles, S.L.2
Holodniy, M.3
-
52
-
-
34247344418
-
Genetic and catalytic efficiency structure of an HCV protease quasispecies
-
Franco S, Parera M, Aparicio E, Clotet B, Martínez MA. Genetic and catalytic efficiency structure of an HCV protease quasispecies. Hepatology 2007; 45:899-910.
-
(2007)
Hepatology
, vol.45
, pp. 899-910
-
-
Franco, S.1
Parera, M.2
Aparicio, E.3
Clotet, B.4
Martínez, M.A.5
-
54
-
-
34547474286
-
Los Alamos hepatitis C virus sequence and human immunology databases: An expanding resource for antiviral research
-
Hraber PT, Leach RW, Reilly LP, Thurmond J, Yusim K, Kuiken C. Los Alamos hepatitis C virus sequence and human immunology databases: an expanding resource for antiviral research. Antivir Chem Chemother 2007; 18:113-123.
-
(2007)
Antivir Chem Chemother
, vol.18
, pp. 113-123
-
-
Hraber, P.T.1
Leach, R.W.2
Reilly, L.P.3
Thurmond, J.4
Yusim, K.5
Kuiken, C.6
-
55
-
-
34548758435
-
Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients
-
Kieffer TL, Sarrazin C, Miller JS, et al. Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients. Hepatology 2007; 43:631-639.
-
(2007)
Hepatology
, vol.43
, pp. 631-639
-
-
Kieffer, T.L.1
Sarrazin, C.2
Miller, J.S.3
-
56
-
-
33947136220
-
Cell culture-adaptive NS3 mutations required for the robust replication of genome-length hepatitis C virus RNA
-
Abe K, Ikeda M, Dansako H, Naka K, Kato N. Cell culture-adaptive NS3 mutations required for the robust replication of genome-length hepatitis C virus RNA. Virus Res 2007; 125:88-97.
-
(2007)
Virus Res
, vol.125
, pp. 88-97
-
-
Abe, K.1
Ikeda, M.2
Dansako, H.3
Naka, K.4
Kato, N.5
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