Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer

Oncology Reports

Volumn 19, Issue 5, 2008, Pages 1339-1345

  Leung, Rebecca Ching Yu ^a   Liu, Stephanie Si ^a   Chan, Kelvin Yuen Kwong ^a   Tam, Kar Fai ^a   Chan, Kar Loen ^a   Wong, Ling Chui ^a   Ngan, Hextan Yuen Sheung ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cervical cancer; Death associated protein kinase; Methylation

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DEATH ASSOCIATED PROTEIN KINASE; MESSENGER RNA; APOPTOSIS REGULATORY PROTEIN; DEATH-ASSOCIATED PROTEIN KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN);

ADULT; ARTICLE; CANCER STAGING; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IRRADIATION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METHYLATION; RADIATION RESPONSE; RADIOSENSITIVITY; RNA ISOLATION; UTERINE CERVIX CANCER; AGED; CPG ISLAND; DNA METHYLATION; GENE EXPRESSION PROFILING; GENETICS; MIDDLE AGED; PHYSIOLOGY; POLYMERASE CHAIN REACTION; RADIATION DOSE; TUMOR CELL LINE; UTERINE CERVIX TUMOR;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS REGULATORY PROTEINS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CELL LINE, TUMOR; CPG ISLANDS; DNA METHYLATION; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); RADIATION TOLERANCE; UTERINE CERVICAL NEOPLASMS;

EID: 47549085777     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.19.5.1339     Document Type: Article

References (28)

1. Baylin SB, Herman JG, Graff JR, Vertino PM and Issa JP: Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 72: 141-196, 1998.
2. Esteller M: Relevance of DNA methylation in the management of cancer. Lancet Oncol 4: 351-358, 2003.
3. Liu SS, Tsang BK, Cheung AN, Xue WC, Cheng DK, Ng TY, Wong LC and Ngan HY: Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma. Eur J Cancer 37: 1104-1110, 2001.
4. Raveh T, Berissi H, Eisenstein M, Spivak T and Kimchi A: A functional genetic screen identifies regions at the C-terminal tail and death-domain of death-associated protein kinase that are critical for its proapoptotic activity. Proc Natl Acad Sci USA 97: 1572-1577, 2000.
5. Kissil JL and Kimchi A: Death-associated proteins: from gene identification to the analysis of their apoptotic and tumour suppressive functions. Mol Med Today 4: 268-274, 1998.
6. Sanchez-Cespedes M, Esteller M, Wu L, Nawroz-Danish H, Yoo GH, Koch WM, Jen J, Herman JG and Sidransky D: Gene promoter hypermethylation in tumors and serum of head and neck cancer patients. Cancer Res 60: 892-895, 2000.
7. Chan MW, Chan LW, Tang NL, Tong JH, Lo KW, Lee TL, Cheung HY, Wong WS, Chan PS, Lai FM, et al: Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients. Clin Cancer Res 8: 464-470, 2002.
8. Esteller M, Sanchez-Cespedes M, Rosell R, Sidransky D, Baylin SB and Herman JG: Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res 59: 67-70, 1999.
9. Kim DH, Nelson HH, Wiencke JK, Zheng S, Christiani DC, Wain JC, Mark EJ and Kelsey KT: p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer. Cancer Res 61: 3419-3424, 2001.
10. Wong TS, Chang HW, Tang KC, Wei WI, Kwong DL, Sham JS, Yuen AP and Kwong YL: High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients. Clin Cancer Res 8: 433-437, 2002.
11. Katzenellenbogen RA, Baylin SB and Herman JG: Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies. Blood 93: 4347-4353, 1999.
12. Collins Y, Dicioccio R, Keitz B, Lele S and Odunsi K: Methylation of death-associated protein kinase in ovarian carcinomas. Int J Gynecol Cancer 16: 195-199, 2006.
13. Kim DH, Nelson HH, Wiencke JK, Christiani DC, Wain JC, Mark EJ and Kelsey KT: Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer. Oncogene 20: 1765-1770, 2001.
14. Tang X, Khuri FR, Lee JJ, Kemp BL, Liu D, Hong WK and Mao L: Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer. J Natl Cancer Inst 92: 1511-1516, 2000.
15. Liu SS, Leung RC, Chan KY, Chiu PM, Cheung AN, Tam KF, Ng TY, Wong LC and Ngan HY: p73 expression is associated with the cellular radio sensitivity in cervical cancer after radiotherapy. Clin Cancer Res 10: 3309-3316, 2004.
16. Chan KY, Ozcelik H, Cheung AN, Ngan HY and Khoo US: Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer. Cancer Res 62: 4151-4156, 2002.
17. Liu SS, Chan KY, Leung RC, Law HK, Leung TW and Ngan HY: Enhancement of the radiosensitivity of cervical cancer cells by overexpressing p73alpha. Mol Cancer Ther 5: 1209-1215, 2006.
18. Tam KF, Ng TY, Liu SS, Tsang PC, Kwong PW and Ngan HY: Potential application of the ATP cell viability assay in the measurement of intrinsic radiosensitivity in cervical cancer. Gynecol Oncol 96: 765-770, 2005.
19. Esteller M, Corn PG, Baylin SB and Herman JG: A gene hypermethylation profile of human cancer. Cancer Res 61: 3225-3229, 2001.
20. Herman JG, Merlo A, Mao L, Lapidus RG, Issa JP, Davidson NE, Sidransky D and Baylin SB: Inactivation of the CDKN2/p16/ MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55: 4525-4530, 1995.
21. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB and Sidransky D: 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1: 686-692, 1995.
22. Dong SM, Kim HS, Rha SH and Sidransky D: Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. Clin Cancer Res 7: 1982-1986, 2001.
23. Narayan G, Arias-Pulido H, Koul S, Vargas H, Zhang FF, Villella J, Schneider A, Terry MB, Mansukhani M and Murty VV: Frequent promoter methylation of CDHl, DAPK, RARB and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome. Mol Cancer 2: 24, 2003.
24. Kissil JL, Feinstein E, Cohen O, Jones PA, Tsai YC, Knowles MA, Eydmann ME and Kimchi A: DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene. Oncogene 15: 403-407, 1997.
25. Inbal B, Cohen O, Polak-Charcon S, Kopolovic J, Vadai E, Eisenbach L and Kimchi A: DAP kinase links the control of apoptosis to metastasis. Nature 390: 180-184, 1997.
26. Soria JC, Rodriguez M, Liu DD, Lee JJ, Hong WK and Mao L: Aberrant promoter methylation of multiple genes in bronchial brush samples from former cigarette smokers. Cancer Res 62: 351-355, 2002.
27. Raveh T, Droguett G, Horwitz MS, DePinho RA and Kimchi A: DAP kinase activates a p 19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nat Cell Biol 3: 1-7, 2001.
28. Tanaka T, Bai T, Yukawa K and Umesaki N: Radiation-induced cell death is independent of the apoptotic signals mediated by death-associated protein kinase in human cervical squamous cell carcinoma cells. Oncol Rep 14: 949-955, 2005.