Anti-arthritic effect and subacute toxicological evaluation of Baccharis genistelloides aqueous extract

Toxicology Letters

Volumn 154, Issue 1-2, 2004, Pages 69-80

  Coelho, M G P ^a   Reis, P A ^a   Gava, V B ^a   Marques, P R ^a   Gayer, C R ^a   Laranja, G A T ^a   Felzenswalb, I ^a   Sabino, K C C ^a  

^a Inst Biol Roberto Alcantara Gomes   (Brazil)

Author keywords

Anti arthritic properties; Baccharis genistelloides; Genotoxicity; Subacute toxicity

Indexed keywords

ANTIRHEUMATIC AGENT; BACCHARIS GENISTELLOIDES EXTRACT; GLUCOSE; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AQUEOUS SOLUTION; ARTHRITIS; ARTICLE; BACCHARIS; BACCHARIS GENISTELLOIDES; BODY WEIGHT; CONTROLLED STUDY; GENOTOXICITY; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; LIVER TOXICITY; LUNG TOXICITY; LYMPH NODE; LYMPHOCYTE PROLIFERATION; MALE; MEDICINAL PLANT; MOUSE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; THYMUS; TRIACYLGLYCEROL BLOOD LEVEL;

ADMINISTRATION, ORAL; ANIMALS; ARTHRITIS, EXPERIMENTAL; ASPARTATE AMINOTRANSFERASES; BACCHARIS; CELL DIVISION; CELL SURVIVAL; COMET ASSAY; DISEASE MODELS, ANIMAL; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; LYMPHOCYTES; MALE; MICE; MICE, INBRED DBA; MUTAGENS; PLANT EXTRACTS;

ANIMALIA; BACCHARIS; GENISTELLOIDES;

EID: 4744365673     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2004.07.004     Document Type: Article

References (57)

1. M.J. Abad, P. Bermejo, E. Gonzales, I. Iglesias, A. Irurzun, and L. Carrasco Antiviral activity of Bolivian plant extracts Gen. Pharmacol. 32 1999 499 503
2. O.P. Agarwal The anti-inflammatory action of nepitrin, a flavonoid Agents Actions 12 1982 298 302
3. N. Ahmad, H. Gali, S. Javed, and R. Agarwal Skin cancer chemopreventive effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor tyrosine kinase signaling and perturbation in cell cycle progression Biochem. Biophys. Res. Commun. 247 1998 294 301
4. S. Akaike, M. Sumino, T. Sekine, S. Seo, N. Kimura, and F. Ikegami A new ent-clerodane diterpene from the aerial parts of Baccharis gaudichaudiana Chem. Pharm. Bull. 51 2003 197 199
5. Almeida, E.R., 1993. Plantas medicinais brasileiras. Conhecimentos Populares e Científicos, Editora Hemus, pp. 124-125.
6. C.H. Baggio, C.S. Freitas, L. Rieck, and M.C. Marques Gastroprotective effects of a crude extract of Baccharis illinita DC in rats Pharmacol. Res. 47 2003 93 98
7. S.P. Boyle, V.L. Dobson, S.J. Duthie, J.A. Kyle, and A.R. Collins Absorption and DNA protective effects of flavonoid glycosides from an onion meal Eur. J. Nutr. 39 2000 213 223
8. D.A. Cifuente, E.J. Borkowski, M.E. Sosa, J.C. Gianello, O.S. Giordano, and C.E. Tonn Clerodane diterpenes from Baccharis sagittalis: insect antifeedant activity Phytochemistry 61 2002 899 905
9. M.A. Chan, J.E. Kohmeier, M. Branden, M. Jung, and S.H. Benedict Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506 Phytother. Res. 13 1999 464 467
10. 2 in cultured NIH3T3 fibroblasts Biol. Pharm. Bull. 26 2003 282 284
11. S.Y. Cho, S.J. Park, M.J. Kwon, T.S. Jeong, S.H. Bok, W.Y. Choi, W.I. Jeong, S.Y. Ryu, S.H. Do, C.S. Lee, J.C. Song, and K.S. Jeong Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-κB pathway in lipopolysaccharide-stimulated macrophage Mol. Cell Biochem. 243 2003 153 160
12. G. Choquet-Kastylevski, R. Tedone, M.T. Ducluzeau, J. Kehren, J.F. Nicolas, and J. Descotes The popliteal lymph node response to streptozotocin is under type 1, MHC class-I restricted CD8(+) T-cell control Toxicology 146 2000 73 82
13. S.Q. De Oliveira, F. Dal-Pizzol, G. Gosmann, D. Guillaume, J.C. Moreira, and E.P. Schenkel Antioxidant activity of Baccharis articulata extracts: isolation of a new compound with antioxidant activity Free Radic. Res. 37 2003 555 559
14. Descotes, J., 1999. Assays of humoral immunity. Assays of cell-mediated immunity. In: An Introduction to Immunotoxicology. Taylor & Francis Ltd., London, UK, pp. 101-108.
15. A.W. Evers, F.W. Kraaimaat, R. Geenen, J.W. Jacobs, and J.W. Bijlsma Long-term predictors of anxiety and depressed mood in early rheumatoid arthritis: a 3 and 5 year follow-up J. Rheumatol. 29 2002 2327 2336
16. D.W. Fairbairn, P.L. Olive, and K.L. O'Neill The Comet assay: a comprehensive review Mut. Res. 339 1995 37 59
17. M. Feldman, and R.N. Maini Anti-TNFα therapy of rheumatoid arthritis: what have we learned? Annu. Rev. Immunol. 19 2001 163 196
18. G.E. Feresin, A. Tapia, A. Gimenez, A.G. Ravelo, S. Zacchino, M. Sortino, and G. Schmeda-Hirschmann Constituents of the Argentinian medicinal plant Baccharis grisebachii and their antimicrobial activity J. Ethnopharmacol. 89 2003 73 80
19. L. Ganju, D. Karan, S. Chanda, K.K. Srivastava, R.C. Sawhney, and W. Selvamurthy Immunomodulatory effects of agents of plant origin Biomed. Pharmacother. 57 2003 296 300
20. R.M. Gene, E. Marin, and T. Adzet Anti-inflammatory effect of aqueous extracts of three species of the genus Baccharis Planta Med. 58 1992 565 566
21. W. Gu, S.R. Brandwein, and S. Banerjee Inhibition of type II collagen induced arthritis in mice by an immunosuppressive extract of Tripterygium wilfordii Hook f J. Rheumatol. 19 1992 682 688
22. W.Z. Gu, and S.R. Brandwein Inhibition of type II collagen-induced arthritis in rats by triptolide Int. J. Immunopharmacol. 20 1998 389 400
23. T.M. Haqqi, D.D. Anthony, S. Gupta, N. Ahmad, M.S. Lee, G.K. Kumar, and H. Mukhtar Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea Proc. Natl. Acad. Sci. U S A 96 1999 4524 4529
24. M. Heinrich Ethnobotany and natural products: the search for new molecules, new treatments of old diseases or a better understanding of indigenous cultures? Curr. Top. Med. Chem. 3 2003 141 154
25. R. Holmdhal, R. Bockermann, Bäcklund, and H. Yamada The molecular pathogenesis of collagen induced arthritis in mice - a model of rheumatoid arthritis Ageing Res. Rev. 1 2002 135 147
26. J. Ishiwa, T. Sato, Y. Mimaki, Y. Sashida, M. Yano, and A. Ito A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts J. Rheumatol. 27 2000 20 25
27. B.B. Jarvis Macrocyclic trichothecenes from Brazilian Baccharis species: from microanalysis to large-scale isolation Phytochem. Anal. 3 1992 241 249
28. M. Kubo, H. Matsuda, M. Tanaka, Y. Kimura, H. Okuda, M. Higashino, T. Tani, K. Namba, and S. Arichi Studies on Scutellariae radix. VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components from Scutellariae radix Chem. Pharm. Bull. 32 1984 2724 2729
29. O.C. Lima, C.C. Figueiredo, B.A.S. Pereira, M.G.P. Coelho, V. Morandi, and L.M. Lopes-Bezerra Adhesion of the human pathogen Sporothrix schenckii to several extracellular matrix proteins Braz. J. Med. Biol. Res. 32 1999 651 657
30. H. Liu, Z.H. Liu, Z.H. Chen, J.W. Yang, and L.S. Li Triptolide: a potent inhibitor of NF-kappa B in T-lymphocytes Acta Pharmacol. Sin. 21 2000 782 786
31. 2-terminal kinases J. Biol. Chem. 271 1996 15703 15707
32. S.F. Melo, S.F. Soares, R.F. Costa, C.R. Silva, M.B.N. Oliveira, R.J.A.C. Bezerra, A. Caldeira-de-Araújo, and M. Bernardo-Filho Effect of the Cymbopogon citrates, Maytenus ilicifolia and Baccharis genistelloides extracts against the stannous chloride oxidative damage in Escherichia coli Mut. Res. 496 2001 33 38
33. B.K. Mookerjee, T.P. Lee, H.A. Lippes, and E. Middleton Jr. Some effects of flavonoids on lymphocyte proliferative responses J. Immunopharmacol. 8 1986 371 392
34. H. Nagata, S. Takekoshi, T. Takagi, T. Honma, and K. Watanabe Antioxidative action of flavonoids, quercetin and catechin, mediated by the activation of glutathione peroxidase Tokai J. Exp. Clin. Med. 24 1999 1 11
35. E.R. Pettipher, and S. Blake Antigen induced arthritis B. Henderson J. Edwards E. Pettipher Mechanisms and Models of Rheumatoid Arthritis vol. 24 1995 Academic Press London 457 470
36. M.G. Pinto Coelho, P.R. Marques, C.R. Gayer, L.C. Vaz, J.F. Neto, and K.C. Sabino Subacute toxicity evaluation of a hydroalcoholic extract of Pterodon pubescens seeds in mice with collagen-induced arthritis J. Ethnopharmacol. 77 2001 159 164
37. Pio Correa, M., 1984. Dicionário das plantas úteis do Brasil e das exóticas cultivadas, vol. III. Ministério da Agricultura, Instituto Brasileiro de Desenvolvimento Florestal, Rio de Janeiro, p. 129.
38. D.W. Pyatt, Y. Yang, B. Mehos, A. Le, W. Stillman, and R.D. Irons Hematotoxicity of the Chinese herbal medicine Tripterygium wilfordii Hook f. in positive human bone marrow cells Mol. Pharmacol. 57 2000 512 518
39. D. Qiu, and P.N. Kao Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook f. Drugs R. D. 4 2003 1 18
40. D. Rai, G. Bhatia, G. Palit, R. Pal, S. Singh, and H.K. Singh Adaptogenic effect of Bacopa monniera (Brahmi) Pharmacol. Biochem. Behav. 75 2003 823 830
41. S.E. Ross, R.O. Williams, L.J. Mason, C. Mauri, L. Marinova-Mutafchieva, A.M. Malfait, R.N. Maini, and M. Feldmann Suppression of TNA-α expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram J. Immunol. 159 1997 6253 6259
42. M. Roy, S. Chakrabarty, D. Sinha, R.K. Bhattacharya, and M. Siddiqi Anticlastogenic, antigenotoxic and apoptotic activity of epigallocatechin gallate green tea polyphenol Mut. Res. 523-524 2003 33 41
43. K.C.C. Sabino, F.A. Castro, J.C.R. Oliveira, S.R.A. Dalmau, and M.G.P. Coelho Successful treatment of collagen-induced arthritis in mice with a hydroalcohol extract of seeds of Pterodon pubescens Phytother. Res. 13 1999 613 615
44. K.C.C. Sabino, C.R.M. Gayer, L.C.A. Vaz, L.R.L. Santos, I. Felzenswalb, and M.G.P. Coelho In vitro and in vivo toxicological study of the Pterodon pubescens seed oil Toxicol. Lett. 108 1999 27 35
45. K. Sai, S. Kai, T. Umemura, A. Tanimura, R. Hasegawa, T. Inoue, and Y. Kurokawa Protective Effects of green tea on hepatotoxicity, oxidative DNA damage and cell proliferation in the rat liver induced by repeated oral administration of 2-nitropropane Food Chem. Toxicol. 36 1998 1043 1051
46. S. Sanchez-Palomino, M.J. Abad, L.M. Bedoya, J. Garcia, E. Gonzales, X. Chiriboga, P. Bermejo, and J. Alcami Screening of South American plants against human immunodeficiency virus: preliminary fractionation of aqueous extract from Bacharis trinervis Biol. Pharm. Bull. 25 2002 1147 1150
47. H. Schroeter, R.J. Williams, R. Matin, L. Iversen, and C.A. Rice-Evans Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein Free Radic. Biol. Med. 29 2000 1222 1233
48. P. Sestili, A. Guidarelli, M. Dacha, and O. Cantoni Quercetin prevents DNA single strand breakage and citotoxicity caused by tert-butylhydroperoxide: free radical scavenging versus iron chelating mechanism Free Radic. Biol. Med. 25 1998 196 200
49. L.A. Shamon, J.M. Pezzuto, R.R. Mehta, S. Wangcharoentrakul, R. Sangsuwan, S. Chaichana, P. Tuchinda, P. Cleason, and V. Reutrakul Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a oxygenated diterpene isolated from Tripterygium wilfordii Cancer Lett. 112 1997 113 117
50. H. Soicke, and E. Leng-Peschlow Characterization of flavonoids from Baccharis trimera and their antihepatotoxic properties Planta Med. 53 1987 37 39
51. Souza, M.P., Mattos, N.E.O., Matos, M.F.J.A., Machado, M.I.L., Craveiro, A.A., 1991. Constituintes ativos de plantas medicinais brasileiras. Fortaleza, UFC.
52. R. Suttisri, D. Kinghorn, A.D. Wright, and O. Sticher Neo-clerodane diterpenoids and other constituents from Baccharis genistelloides Phytochemistry 35 1994 443 446
53. L.M.B. Torres, M.T. Gamberini, N.F. Roque, M.T. Lima-Landman, C. Souccar, and A.J. Lapa Diterpene from Baccharis trimera with a relaxant effect on rat vascular smooth muscle Phytochemistry 55 2000 617 619
54. A. van der Heide, J.W.G. Jacobs, G.A. van Albada-Kuipers, F.W. Kraaimaat, R. Geenen, and J.W.J. Bijlsma Physical disability and psychological well being in recent onset rheumatoid arthritis J. Rheumatol. 21 1994 28 32
55. C. Weimann, U. Goransson, P. Pongprayoon-Claeson, L. Bohlin, H. Rimpler, and M. Heinrich Spasmolytic effects of Baccharis conferta and some of its constituents J. Pharm. Pharmacol. 54 2002 99 104
56. T. Yamashita, T. Sasahara, S.E. Pomeroy, G. Collier, and P.J. Nestel Arterial compliance, blood pressure, plasma leptin, and plasma lipids in women are improved with weight reduction equally with a meat-based diet and a plant-based diet Metabolism 47 1998 1308 1314
57. K.M. You, K.H. Som, H.W. Chang, S.S. Kang, and H.P. Kim Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro Planta Med. 64 1998 546 550