Probing the substrate specificity of golgi α-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant

Journal of the American Chemical Society

Volumn 130, Issue 28, 2008, Pages 8975-8983

  Zhong, Wei ^a   Kuntz, Douglas A ^b   Ember, Brian ^a   Singh, Harminder ^a   Moremen, Kelley W ^a   Rose, David R ^b,c   Boons, Geert Jan ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BINDING SITES; CELL MEMBRANES; FOOD ADDITIVES; SUBSTRATES;

ASPARTATE (ASP); CONFORMATIONAL CHANGES; HIGH ENERGIES; IN-CELL; MANNOSIDASE; MUTANT ENZYMES; N GLYCAN PROCESSING; SUBSTRATE SPECIFICITY; X RAY CRYSTAL STRUCTURES;

OLIGOSACCHARIDES;

ALPHA MANNOSIDASE; ASPARTIC ACID; MANNOSIDE; OLIGOSACCHARIDE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CELL SURFACE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DROSOPHILA; ENZYME INHIBITION; ENZYME SPECIFICITY; GOLGI COMPLEX; HYDROGEN BOND; KINETICS; MOLECULAR INTERACTION; NONHUMAN; PROTEIN FUNCTION; PROTEIN STRUCTURE; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA; GLYCOSYLATION; MANNOSE; MANNOSIDASES; MODELS, MOLECULAR; MUTATION; OLIGOSACCHARIDES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIOGLYCOSIDES;

EID: 47349123478     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja711248y     Document Type: Article

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