Structure of Golgi α-mannosidase II: A target for inhibition of growth and metastasis of cancer cells

EMBO Journal

Volumn 20, Issue 12, 2001, Pages 3008-3017

  Van Den Elsen, Jean M H ^a   Kuntz, Douglas A ^b   Rose, David R ^b  

^a University of Bath   (United Kingdom)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cancer therapy; Drug design; Golgi mannosidase II; N glycosylation pathway; X ray crystallography

Indexed keywords

1 DEOXYMANNONOJIRIMYCIN; ALPHA MANNOSIDASE; ENZYME INHIBITOR; MANNOSE; SWAINSONINE; ZINC;

ARTICLE; CANCER INHIBITION; CANCER THERAPY; CRYSTAL STRUCTURE; DROSOPHILA; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING;

1-DEOXYNOJIRIMYCIN; AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BINDING SITES; CATALYSIS; CELL DIVISION; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA MELANOGASTER; ENZYME INHIBITORS; GENE EXPRESSION; MANNOSIDASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASM METASTASIS; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY; SWAINSONINE; TUMOR CELLS, CULTURED;

EID: 0035875663     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.12.3008     Document Type: Article

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