The role of the active site Zn in the catalytic mechanism of the GH38 Golgi α-mannosidase II: Implications from noeuromycin inhibition

Biocatalysis and Biotransformation

Volumn 24, Issue 1-2, 2006, Pages 55-61

  Kuntz, Douglas A ^a   Liu, Huizhen ^c   Bols, Mikael ^c   Rose, David R ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

Enzyme catalytic mechanism; Glycosidase inhibitors; Glycosyl hydrolase; Mannosidase; X ray crystallography

Indexed keywords

ATOMS; CATALYSIS; COMPLEXATION; CONFORMATIONS; ENZYMES; MOLECULAR STRUCTURE; PROTEINS; SUBSTRATES; SYNTHESIS (CHEMICAL); ZINC;

ANTI-INFLAMMATORY COMPOUND; GLYCOSYL HYDROLASE; NOEUROMYCIN INHIBITION;

ENZYME INHIBITION;

ALPHA MANNOSIDASE; GLYCOSIDASE INHIBITOR; NOEUROMYCIN; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION;

EUKARYOTA;

EID: 33646829509     PISSN: 10242422     EISSN: 10292446     Source Type: Journal    
DOI: 10.1080/10242420500533242     Document Type: Article

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