메뉴 건너뛰기




Volumn , Issue , 2008, Pages

The PPAR-γ agonist 15-deoxy- Δ 12, 14-prostaglandin J 2 attenuates microglial production of IL-12 family cytokines: Potential relevance to Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 23; MYELOID DIFFERENTIATION FACTOR 88; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST;

EID: 47349118631     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2008/349185     Document Type: Article
Times cited : (21)

References (55)
  • 1
    • 20244364226 scopus 로고    scopus 로고
    • Up-regulation of the inflammatory cytokines IFN- γ and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APPSWE transgenic mice
    • Abbas N., Bednar I., Mix E., Up-regulation of the inflammatory cytokines IFN- γ and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APPSWE transgenic mice Journal of Neuroimmunology 2002 126 1-2 50 57
    • (2002) Journal of Neuroimmunology , vol.126 , Issue.12 , pp. 50-57
    • Abbas, N.1    Bednar, I.2    Mix, E.3
  • 2
    • 0036780877 scopus 로고    scopus 로고
    • Amyloid- β immunotherapy for Alzheimer's disease: The end of the beginning
    • Schenk D., Amyloid- β immunotherapy for Alzheimer's disease: the end of the beginning Nature Reviews Neuroscience 2002 3 10 824 828
    • (2002) Nature Reviews Neuroscience , vol.3 , Issue.10 , pp. 824-828
    • Schenk, D.1
  • 3
    • 33646384419 scopus 로고    scopus 로고
    • Immunology and immunotherapy of Alzheimer's disease
    • Weiner H. L., Frenkel D., Immunology and immunotherapy of Alzheimer's disease Nature Reviews Immunology 2006 6 5 404 416
    • (2006) Nature Reviews Immunology , vol.6 , Issue.5 , pp. 404-416
    • Weiner, H.L.1    Frenkel, D.2
  • 5
    • 84880189986 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer's disease
    • supplement 3
    • Morgan D., Immunotherapy for Alzheimer's disease Journal of Alzheimer's Disease 2006 9 supplement 3 425 432
    • (2006) Journal of Alzheimer's Disease , vol.9 , pp. 425-432
    • Morgan, D.1
  • 6
    • 0034700471 scopus 로고    scopus 로고
    • A β peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
    • Janus C., Pearson J., McLaurin J., A β peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease Nature 2000 408 6815 979 982
    • (2000) Nature , vol.408 , Issue.6815 , pp. 979-982
    • Janus, C.1    Pearson, J.2    McLaurin, J.3
  • 7
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid- β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D., Barbour R., Dunn W., Immunization with amyloid- β attenuates Alzheimer-disease-like pathology in the PDAPP mouse Nature 1999 400 6740 173 177
    • (1999) Nature , vol.400 , Issue.6740 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3
  • 8
    • 0035544150 scopus 로고    scopus 로고
    • Number of a β inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels
    • Wilcock D. M., Gordon M. N., Ugen K. E., Number of A β inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels DNA and Cell Biology 2001 20 11 731 736
    • (2001) DNA and Cell Biology , vol.20 , Issue.11 , pp. 731-736
    • Wilcock, D.M.1    Gordon, M.N.2    Ugen, K.E.3
  • 9
    • 0037031861 scopus 로고    scopus 로고
    • Passive immunization against β -amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation
    • Mohajeri M. H., Saini K., Schultz J. G., Wollmer M. A., Hock C., Nitsch R. M., Passive immunization against β -amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation Journal of Biological Chemistry 2002 277 36 33012 33017
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.36 , pp. 33012-33017
    • Mohajeri, M.H.1    Saini, K.2    Schultz, J.G.3    Wollmer, M.A.4    Hock, C.5    Nitsch, R.M.6
  • 10
    • 3042839092 scopus 로고    scopus 로고
    • Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition
    • Wilcock D. M., Rojiani A., Rosenthal A., Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition Journal of Neuroscience 2004 24 27 6144 6151
    • (2004) Journal of Neuroscience , vol.24 , Issue.27 , pp. 6144-6151
    • Wilcock, D.M.1    Rojiani, A.2    Rosenthal, A.3
  • 11
    • 10744230547 scopus 로고    scopus 로고
    • Subacute meningoencephalitis in a subset of patients with AD after a β 42 immunization
    • Orgogozo J.-M., Gilman S., Dartigues J.-F., Subacute meningoencephalitis in a subset of patients with AD after A β 42 immunization Neurology 2003 61 1 46 54
    • (2003) Neurology , vol.61 , Issue.1 , pp. 46-54
    • Orgogozo, J.-M.1    Gilman, S.2    Dartigues, J.-F.3
  • 12
    • 33645517069 scopus 로고    scopus 로고
    • A β -induced meningoencephalitis is IFN- γ -dependent and is associated with T cell-dependent clearance of a β in a mouse model of Alzheimer's disease
    • Monsonego A., Imitola J., Petrovic S., A β -induced meningoencephalitis is IFN- γ -dependent and is associated with T cell-dependent clearance of A β in a mouse model of Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 2006 103 13 5048 5053
    • (2006) Proceedings of the National Academy of Sciences of the United States of America , vol.103 , Issue.13 , pp. 5048-5053
    • Monsonego, A.1    Imitola, J.2    Petrovic, S.3
  • 13
    • 33847613885 scopus 로고    scopus 로고
    • Inflammatory processes in Alzheimer's disease
    • Heneka M. T., O'Banion M. K., Inflammatory processes in Alzheimer's disease Journal of Neuroimmunology 2007 184 1-2 69 91
    • (2007) Journal of Neuroimmunology , vol.184 , Issue.12 , pp. 69-91
    • Heneka, M.T.1    O'banion, M.K.2
  • 14
    • 0030000385 scopus 로고    scopus 로고
    • The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease
    • Breitner J. C. S., The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease Annual Review of Medicine 1996 47 401 411
    • (1996) Annual Review of Medicine , vol.47 , pp. 401-411
    • Breitner, J.C.S.1
  • 15
    • 0028953529 scopus 로고
    • Activation of microglial cells by β -amyloid protein and interferon- γ
    • Meda L., Cassatella M. A., Szendrei G. I., Activation of microglial cells by β -amyloid protein and interferon- γ Nature 1995 374 6523 647 650
    • (1995) Nature , vol.374 , Issue.6523 , pp. 647-650
    • Meda, L.1    Cassatella, M.A.2    Szendrei, G.I.3
  • 16
    • 22544434621 scopus 로고    scopus 로고
    • Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice
    • Saura C. A., Chen G., Malkani S., Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice Journal of Neuroscience 2005 25 29 6755 6764
    • (2005) Journal of Neuroscience , vol.25 , Issue.29 , pp. 6755-6764
    • Saura, C.A.1    Chen, G.2    Malkani, S.3
  • 17
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann B., Lesley R., Blom B., Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 2000 13 5 715 725
    • (2000) Immunity , vol.13 , Issue.5 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3
  • 19
    • 0036677420 scopus 로고    scopus 로고
    • Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
    • Becher B., Durell B. G., Noelle R. J., Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12 Journal of Clinical Investigation 2002 110 4 493 497
    • (2002) Journal of Clinical Investigation , vol.110 , Issue.4 , pp. 493-497
    • Becher, B.1    Durell, B.G.2    Noelle, R.J.3
  • 20
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua D. J., Sherlock J., Chen Y., Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 2003 421 6924 744 748
    • (2003) Nature , vol.421 , Issue.6924 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3
  • 21
    • 0037114150 scopus 로고    scopus 로고
    • IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
    • Gran B., Zhang G.-X., Yu S., IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination Journal of Immunology 2002 169 12 7104 7110
    • (2002) Journal of Immunology , vol.169 , Issue.12 , pp. 7104-7110
    • Gran, B.1    Zhang, G.-X.2    Yu, S.3
  • 22
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B., Wahli W., Peroxisome proliferator-activated receptors: nuclear control of metabolism Endocrine Reviews 1999 20 5 649 688
    • (1999) Endocrine Reviews , vol.20 , Issue.5 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 23
    • 7244226629 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: Old and new mechanisms of action
    • Gasparini L., Ongini E., Wenk G., Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action Journal of Neurochemistry 2004 91 3 521 536
    • (2004) Journal of Neurochemistry , vol.91 , Issue.3 , pp. 521-536
    • Gasparini, L.1    Ongini, E.2    Wenk, G.3
  • 24
    • 20444499367 scopus 로고    scopus 로고
    • Acute treatment with the PPAR γ agonist pioglitazone and ibuprofen reduces glial inflammation and a β 1-42 levels in APPV717I transgenic mice
    • Heneka M. T., Sastre M., Dumitrescu-Ozimek L., Acute treatment with the PPAR γ agonist pioglitazone and ibuprofen reduces glial inflammation and A β 1-42 levels in APPV717I transgenic mice Brain 2005 128 6 1442 1453
    • (2005) Brain , vol.128 , Issue.6 , pp. 1442-1453
    • Heneka, M.T.1    Sastre, M.2    Dumitrescu-Ozimek, L.3
  • 26
    • 17844410902 scopus 로고    scopus 로고
    • Thyrocytes express a functional Toll-like receptor 3: Overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis
    • Harii N., Lewis C. J., Vasko V., Thyrocytes express a functional Toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis Molecular Endocrinology 2005 19 5 1231 1250
    • (2005) Molecular Endocrinology , vol.19 , Issue.5 , pp. 1231-1250
    • Harii, N.1    Lewis, C.J.2    Vasko, V.3
  • 27
    • 33645322938 scopus 로고    scopus 로고
    • Toll-like receptors in central nervous system glial inflammation and homeostasis
    • Kielian T., Toll-like receptors in central nervous system glial inflammation and homeostasis Journal of Neuroscience Research 2006 83 5 711 730
    • (2006) Journal of Neuroscience Research , vol.83 , Issue.5 , pp. 711-730
    • Kielian, T.1
  • 28
    • 36549001727 scopus 로고    scopus 로고
    • Role of TLR4 polymorphisms in inflammatory responses: Implications for unsuccessful aging
    • Balistreri C. R., Candore G., Listì F., Role of TLR4 polymorphisms in inflammatory responses: implications for unsuccessful aging Annals of the New York Academy of Sciences 2007 1119 1 203 207
    • (2007) Annals of the New York Academy of Sciences , vol.1119 , Issue.1 , pp. 203-207
    • Balistreri, C.R.1    Candore, G.2    Listì, F.3
  • 29
    • 35848963223 scopus 로고    scopus 로고
    • Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease
    • Walter S., Letiembre M., Liu Y., Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease Cellular Physiology and Biochemistry 2007 20 6 947 956
    • (2007) Cellular Physiology and Biochemistry , vol.20 , Issue.6 , pp. 947-956
    • Walter, S.1    Letiembre, M.2    Liu, Y.3
  • 30
    • 33750576993 scopus 로고    scopus 로고
    • Role of toll-like receptor signalling in a β uptake and clearance
    • Tahara K., Kim H.-D., Jin J.-J., Maxwell J. A., Li L., Fukuchi K., Role of toll-like receptor signalling in A β uptake and clearance Brain 2006 129 11 3006 3019
    • (2006) Brain , vol.129 , Issue.11 , pp. 3006-3019
    • Tahara, K.1    Kim, H.-D.2    Jin, J.-J.3    Maxwell, J.A.4    Li, L.5    Fukuchi, K.6
  • 31
    • 0019313317 scopus 로고
    • Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue
    • McCarthy K. D., de Vellis J., Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue Journal of Cell Biology 1980 85 3 890 902
    • (1980) Journal of Cell Biology , vol.85 , Issue.3 , pp. 890-902
    • McCarthy, K.D.1    De Vellis, J.2
  • 32
    • 0035795009 scopus 로고    scopus 로고
    • The cyclopentone prostaglandin 15-deoxy- Δ12,14 prostaglandin J2 represses nitric oxide, TNF- α, and IL-12 production by microglial cells
    • Drew P. D., Chavis J. A., The cyclopentone prostaglandin 15-deoxy- Δ12,14 prostaglandin J2 represses nitric oxide, TNF- α, and IL-12 production by microglial cells Journal of Neuroimmunology 2001 115 1-2 28 35
    • (2001) Journal of Neuroimmunology , vol.115 , Issue.12 , pp. 28-35
    • Drew, P.D.1    Chavis, J.A.2
  • 34
    • 33846468972 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor- γ agonists suppress the production of IL-12 family cytokines by activated glia
    • Xu J., Drew P. D., Peroxisome proliferator-activated receptor- γ agonists suppress the production of IL-12 family cytokines by activated glia Journal of Immunology 2007 178 3 1904 1913
    • (2007) Journal of Immunology , vol.178 , Issue.3 , pp. 1904-1913
    • Xu, J.1    Drew, P.D.2
  • 35
    • 33646938005 scopus 로고    scopus 로고
    • Short amyloid- β (A β) immunogens reduce cerebral a β load and learning deficits in an Alzheimer's disease mouse model in the absence of an a β -specific cellular immune response
    • Maier M., Seabrook T. J., Lazo N. D., Short amyloid- β (A β) immunogens reduce cerebral A β load and learning deficits in an Alzheimer's disease mouse model in the absence of an A β -specific cellular immune response Journal of Neuroscience 2006 26 18 4717 4728
    • (2006) Journal of Neuroscience , vol.26 , Issue.18 , pp. 4717-4728
    • Maier, M.1    Seabrook, T.J.2    Lazo, N.D.3
  • 36
    • 84984755327 scopus 로고    scopus 로고
    • A β peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • Erratum in Nature, vol. 412, no. 6847, p. 660, 2001
    • Morgan D., Diamond D. M., Gottschall P. E., A β peptide vaccination prevents memory loss in an animal model of Alzheimer's disease Nature 2000 408 6815 982 985. Erratum in Nature, vol. 412, no. 6847, p. 660, 2001
    • (2000) Nature , vol.408 , Issue.6815 , pp. 982-985
    • Morgan, D.1    Diamond, D.M.2    Gottschall, P.E.3
  • 37
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid β -peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard F., Cannon C., Barbour R., Peripherally administered antibodies against amyloid β -peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease Nature Medicine 2000 6 8 916 919
    • (2000) Nature Medicine , vol.6 , Issue.8 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3
  • 39
    • 11444267243 scopus 로고    scopus 로고
    • Evaluation of the safety and immunogenicity of synthetic a β 42 (AN1792) in patients with AD
    • Bayer A. J., Bullock R., Jones R. W., Evaluation of the safety and immunogenicity of synthetic A β 42 (AN1792) in patients with AD Neurology 2005 64 1 94 101
    • (2005) Neurology , vol.64 , Issue.1 , pp. 94-101
    • Bayer, A.J.1    Bullock, R.2    Jones, R.W.3
  • 40
    • 20944448555 scopus 로고    scopus 로고
    • Clinical effects of a β immunization (AN1792) in patients with AD in an interrupted trial
    • Gilman S., Koller M., Black R. S., Clinical effects of A β immunization (AN1792) in patients with AD in an interrupted trial Neurology 2005 64 9 1553 1562
    • (2005) Neurology , vol.64 , Issue.9 , pp. 1553-1562
    • Gilman, S.1    Koller, M.2    Black, R.S.3
  • 41
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid- β peptide: A case report
    • Nicolll J. A. R., Wilkinson D., Holmes C., Steart P., Markham H., Weller R. O., Neuropathology of human Alzheimer disease after immunization with amyloid- β peptide: a case report Nature Medicine 2003 9 4 448 452
    • (2003) Nature Medicine , vol.9 , Issue.4 , pp. 448-452
    • Nicolll, J.A.R.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 42
    • 1042265187 scopus 로고    scopus 로고
    • Neuropathology and pathogenesis of encephalitis following amyloid- β immunization in Alzheimer's disease
    • Ferrer I., Boada Rovira M., Sánchez Guerra M. L., Rey M. J., Costa-Jussá F., Neuropathology and pathogenesis of encephalitis following amyloid- β immunization in Alzheimer's disease Brain Pathology 2004 14 1 11 20
    • (2004) Brain Pathology , vol.14 , Issue.1 , pp. 11-20
    • Ferrer, I.1    Boada Rovira, M.2    Sánchez Guerra, M.L.3    Rey, M.J.4    Costa-Jussá, F.5
  • 43
    • 19944429065 scopus 로고    scopus 로고
    • A β vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease
    • Masliah E., Hansen L., Adame A., A β vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease Neurology 2005 64 1 129 131
    • (2005) Neurology , vol.64 , Issue.1 , pp. 129-131
    • Masliah, E.1    Hansen, L.2    Adame, A.3
  • 44
    • 0037180823 scopus 로고    scopus 로고
    • Inflammation and therapeutic vaccination in CNS diseases
    • Weiner H. L., Selkoe D. J., Inflammation and therapeutic vaccination in CNS diseases Nature 2002 420 6917 879 884
    • (2002) Nature , vol.420 , Issue.6917 , pp. 879-884
    • Weiner, H.L.1    Selkoe, D.J.2
  • 45
    • 0242268945 scopus 로고    scopus 로고
    • Immunotherapeutic approaches to Alzheimer's disease
    • Monsonego A., Weiner H. L., Immunotherapeutic approaches to Alzheimer's disease Science 2003 302 5646 834 838
    • (2003) Science , vol.302 , Issue.5646 , pp. 834-838
    • Monsonego, A.1    Weiner, H.L.2
  • 46
    • 0041886776 scopus 로고    scopus 로고
    • Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease
    • Monsonego A., Zota V., Karni A., Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease Journal of Clinical Investigation 2003 112 3 415 422
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.3 , pp. 415-422
    • Monsonego, A.1    Zota, V.2    Karni, A.3
  • 47
    • 0037311051 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor- γ agonists on central nervous system inflammation
    • Kielian T., Drew P. D., Effects of peroxisome proliferator-activated receptor- γ agonists on central nervous system inflammation Journal of Neuroscience Research 2003 71 3 315 325
    • (2003) Journal of Neuroscience Research , vol.71 , Issue.3 , pp. 315-325
    • Kielian, T.1    Drew, P.D.2
  • 48
    • 0035132169 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor- γ in Alzheimer's disease
    • Heneka M. T., Landreth G. E., Feinstein D. L., Role of peroxisome proliferator-activated receptor- γ in Alzheimer's disease Annals of Neurology 2001 49 2 276
    • (2001) Annals of Neurology , vol.49 , Issue.2 , pp. 276
    • Heneka, M.T.1    Landreth, G.E.2    Feinstein, D.L.3
  • 49
    • 0041921071 scopus 로고    scopus 로고
    • Anti-inflammatory drug therapy alters β -amyloid processing and deposition in an animal model of Alzheimer's disease
    • Yan Q., Zhang J., Liu H., Anti-inflammatory drug therapy alters β -amyloid processing and deposition in an animal model of Alzheimer's disease Journal of Neuroscience 2003 23 20 7504 7509
    • (2003) Journal of Neuroscience , vol.23 , Issue.20 , pp. 7504-7509
    • Yan, Q.1    Zhang, J.2    Liu, H.3
  • 51
    • 0242609178 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and peroxisome proliferator- activated receptor- γ agonists modulate immunostimulated processing of amyloid precursor protein through regulation of β -secretase
    • Sastre M., Dewachter I., Landreth G. E., Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor- γ agonists modulate immunostimulated processing of amyloid precursor protein through regulation of β -secretase Journal of Neuroscience 2003 23 30 9796 9804
    • (2003) Journal of Neuroscience , vol.23 , Issue.30 , pp. 9796-9804
    • Sastre, M.1    Dewachter, I.2    Landreth, G.E.3
  • 52
    • 33644592598 scopus 로고    scopus 로고
    • Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: A preliminary study
    • Watson G. S., Cholerton B. A., Reger M. A., Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study American Journal of Geriatric Psychiatry 2005 13 11 950 958
    • (2005) American Journal of Geriatric Psychiatry , vol.13 , Issue.11 , pp. 950-958
    • Watson, G.S.1    Cholerton, B.A.2    Reger, M.A.3
  • 53
    • 33745266146 scopus 로고    scopus 로고
    • Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease
    • Risner M. E., Saunders A. M., Altman J. F. B., Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease The Pharmacogenomics Journal 2006 6 4 246 254
    • (2006) The Pharmacogenomics Journal , vol.6 , Issue.4 , pp. 246-254
    • Risner, M.E.1    Saunders, A.M.2    Altman, J.F.B.3
  • 54
    • 1342332161 scopus 로고    scopus 로고
    • The LPS receptor (CD14) links innate immunity with Alzheimer's disease
    • Fassbender K., Walter S., Kühl S., The LPS receptor (CD14) links innate immunity with Alzheimer's disease The FASEB Journal 2004 18 1 203 205
    • (2004) The FASEB Journal , vol.18 , Issue.1 , pp. 203-205
    • Fassbender, K.1    Walter, S.2    Kühl, S.3
  • 55
    • 23444448277 scopus 로고    scopus 로고
    • LPS receptor (CD14): A receptor for phagocytosis of Alzheimer's amyloid peptide
    • Liu Y., Walter S., Stagi M., LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide Brain 2005 128 8 1778 1789
    • (2005) Brain , vol.128 , Issue.8 , pp. 1778-1789
    • Liu, Y.1    Walter, S.2    Stagi, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.