TNF-α impairs the S-G2/M cell cycle checkpoint and cyclobutane pyrimidine dimer repair in premalignant skin cells: Role of the PI3K-Akt pathway

Journal of Investigative Dermatology

Volumn 128, Issue 8, 2008, Pages 2069-2077

  Faurschou, Annesofie ^a,c   Gniadecki, Robert ^a   Calay, Damien ^a,b   Wulf, Hans Christian ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Facultes Universitaires Notre Dame de la Paix Faculte de Medicine   (Belgium)

^c BISPEBJERG HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CYCLOBUTANE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN BAD; PROTEIN KINASE B; PYRIMIDINE; TRANSCRIPTION FACTOR FKHRL1; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL REGENERATION; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; KERATINOCYTE; MUTAGENESIS; PRIORITY JOURNAL; ULTRAVIOLET IRRADIATION;

EID: 47349115562     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2008.19     Document Type: Article

References (38)

1. Altomare DA, Testa JR (2005) Perturbations of the AKT signaling pathway in human cancer. Oncogene 24:7455-64
2. Anthonsen MW, Andersen S, Solhaug A, Johansen B (2001) Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between phospholipase A2s regulating NF-kappa B activation in response to tumor necrosis factor-alpha and interleukin-1beta. J Biol Chem 276:35344-51
3. Arnott CH, Scott KA, Moore RJ, Robinson SC, Thompson RG, Balkwill FR (2004) Expression of both TNF-alpha receptor subtypes is essential for optimal skin tumour development. Oncogene 23:1902-10
4. Biggs WH III, Meisenhelder J, Hunter T, Cavenee WK, Arden KC (1999) Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci USA 96:7421-6
5. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE (1988) Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 106:761-71
6. Boukamp P, Peter W, Pascheberg U, Altmeier S, Fasching C, Stanbridge EJ et al. (1995) Step-wise progression in human skin carcinogenesis in vitro involves mutational inactivation of p53, rasH oncogene activation and additional chromosome loss. Oncogene 11:961-9
7. Calautti E, Li J, Saoncella S, Brissette JL, Goetinck PF (2005) Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death. J Biol Chem 280:32856-65
8. Dajee M, Lazarov M, Zhang JY, Cai T, Green CL, Russell AJ et al. (2003) NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Nature 421:639-43
9. Dijkers PF, Medema RH, Lammers JW, Koenderman L, Coffer PJ (2000) Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 10:1201-4
10. Greer EL, Brunet A (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24:7410-25
11. Henry MK, Lynch JT, Eapen AK, Quelle FW (2001) DNA damage-induced cell-cycle arrest of hematopoietic cells is overridden by activation of the PI-3 kinase/Akt signaling pathway. Blood 98:834-41
12. Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY et al. (2004) IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117:225-37
13. Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK (2006) The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell 124:1225-39
14. Kandel ES, Skeen J, Majewski N, Di Cristofano A, Pandolfi PP, Feliciano CS et al. (2002) Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Mol Cell Biol 22:7831-41
15. Kim S, Domon-Dell C, Kang J, Chung DH, Freund JN, Evers BM (2004) Down-regulation of the tumor suppressor PTEN by the tumor necrosis factoralpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop. J Biol Chem 279:4285-91
16. Kock A, Schwarz T, Kirnbauer R, Urbanski A, Perry P, Ansel JC et al. (1990) Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J Exp Med 172:1609-14
17. Lisby S, Faurschou A, Gniadecki R (2006) The autocrine TNFalpha signalling loop in keratinocytes requires atypical PKC species and NF-kappaB activation but is independent of cholesterol-enriched membrane microdomains. Biochem Pharmacol 73(Suppl 4):526-33
18. Loercher A, Lee TL, Ricker JL, Howard A, Geoghegen J, Chen Z et al. (2004) Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma. Cancer Res 64:6511-23
19. Medema RH, Kops GJ, Bos JL, Burgering BM (2000) AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404:782-7
20. Moore RJ, Owens DM, Stamp G, Arnott C, Burke F, East N et al. (1999) Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nat Med 5:828-31
21. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB (1999) NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401:82-5
22. Peng XD, Xu PZ, Chen ML, Hahn-Windgassen A, Skeen J, Jacobs J et al. (2003) Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 17:1352-65
23. Ramaswamy S, Nakamura N, Sansal I, Bergeron L, Sellers WR (2002) A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell 2:81-91
24. Ren Q, Kari C, Quadros MR, Burd R, McCue P, Dicker AP et al. (2006) Malignant transformation of immortalized HaCaT keratinocytes through deregulated nuclear factor kappaB signaling. Cancer Res 66:5209-15
25. Schwarz A, Bhardwaj R, Aragane Y, Mahnke K, Riemann H, Metze D et al. (1995) Ultraviolet-B-induced apoptosis of keratinocytes: evidence for partial involvement of tumor necrosis factor-alpha in the formation of sunburn cells. J Invest Dermatol 104:922-7
26. Segrelles C, Moral M, Lara MF, Ruiz S, Santos M, Leis H et al. (2006) Molecular determinants of Akt-induced keratinocyte transformation. Oncogene 25:1174-85
27. Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J et al. (1999) PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci USA 96:6199-204
28. Suzuki A, Itami S, Ohishi M, Hamada K, Inoue T, Komazawa N et al. (2003) Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer Res 63:674-81
29. Tang TT, Dowbenko D, Jackson A, Toney L, Lewin DA, Dent AL et al. (2002) The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. J Biol Chem 277:14255-65
30. Thorn T, Gniadecki R, Petersen AB, Vicanova J, Wulf HC (2001) Differences in activation of G2/M checkpoint in keratinocytes after genotoxic stress induced by hydrogen peroxide and ultraviolet A radiation. Free Radic Res 35:405-16
31. Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ Jr, DiStefano PS et al. (2002) DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296:530-4
32. Vasudevan KM, Gurumurthy S, Rangnekar VM (2004) Suppression of PTEN expression by NF-kappa B prevents apoptosis. Mol Cell Biol 24:1007-21
33. Wang HQ, Quan T, He T, Franke TF, Voorhees JJ, Fisher GJ (2003) Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes. J Biol Chem 278:45737-45
34. Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124:471-84
35. You H, Yamamoto K, Mak TW (2006) Regulation of transactivation- independent proapoptotic activity of p53 by FOXO3a. Proc Natl Acad Sci USA 103:9051-6
36. Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ (1996) Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87:619-28
37. 2-kinase signalling promotes human neoplasia. Cancer Res 67:3827-34
38. Zhang QS, Maddock DA, Chen JP, Heo S, Chiu C, Lai D et al. (2001) Cytokine-induced p38 activation feedback regulates the prolonged activation of AKT cell survival pathway initiated by reactive oxygen species in response to UV irradiation in human keratinocytes. Int J Oncol 19:1057-61