Differences in hepatic cytochrome P450 activity correlate with the strain-specific biotransformation of medetomidine in AX/JU and IIIVO/JU inbred rabbits

Journal of Veterinary Pharmacology and Therapeutics

Volumn 31, Issue 4, 2008, Pages 368-377

  Avsaroglu, H ^a,c   Bull, S ^b   Maas Bakker, R F ^c   Scherpenisse, P ^d   Van Lith, H A ^c   Bergwerff, A A ^d   Hellebrekers, L J ^c   Van Zutphen, L F M ^c   Fink Gremmels, J ^c  

^a UTRECHT UNIVERSITY   (Netherlands)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

^c UTRECHT UNIVERSITY   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CYTOCHROME P450; CYTOCHROME P450 2D; CYTOCHROME P450 2E1; ISOENZYME; MEDETOMIDINE;

ANIMAL TISSUE; ARTICLE; DRUG TRANSFORMATION; ENZYME ACTIVITY; FEMALE; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SEX DIFFERENCE; STRAIN DIFFERENCE; TANDEM MASS SPECTROMETRY;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FEMALE; ISOENZYMES; MALE; MEDETOMIDINE; MICROSOMES, LIVER; RABBITS; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY;

ORYCTOLAGUS CUNICULUS;

EID: 47349100164     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2008.00969.x     Document Type: Article

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