α-Naphthoflavone acts as activator and reversible or irreversible inhibitor of rabbit microsomal CYP3A6

Chemico-Biological Interactions

Volumn 138, Issue 1, 2001, Pages 85-106

  Boek Dohalská, Lucie ^a   Hodek, Petr ^a   Šulc, Miroslav ^a   Stiborová, Marie ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

naphthoflavone; CYP3A4; CYP3A6; Cytochrome P450; Mechanism based inhibition; Metabolism; Modulation of enzyme activities

Indexed keywords

ALPHA NAPHTHOFLAVONE; CARBON MONOXIDE; CYTOCHROME P450 3A6; CYTOCHROME P450 ISOENZYME; ERYTHROMYCIN; ESTRADIOL; OXIDOREDUCTASE; PROGESTERONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIFAMPICIN; TAMOXIFEN; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; DIALYSIS; ENZYME ACTIVITY; ENZYME INACTIVATION; HUMAN; HYDROXYLATION; KINETICS; LIVER MICROSOME; MALE; METABOLITE; METHYLATION; NONHUMAN; PROTEIN BINDING; RABBIT; SPECTROSCOPY; STIMULATION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BENZOFLAVONES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; ERYTHROMYCIN; ESTRADIOL; HYDROXYLATION; MALE; METHYLATION; MICROSOMES, LIVER; RABBITS; RECOMBINANT PROTEINS; TAMOXIFEN;

ORYCTOLAGUS CUNICULUS;

EID: 0035950397     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(01)00263-0     Document Type: Article

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