CYP2E1 substrate inhibition: Mechanistic interpretation through an effector site for monocyclic compounds

Journal of Biological Chemistry

Volumn 283, Issue 6, 2008, Pages 3487-3496

  Collom, Samuel L ^a   Laddusaw, Ryan M ^b   Burch, Amber M ^a   Kuzmic, Petr ^c   Perry Jr , Martin D ^b   Miller, Grover P ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b OUACHITA BAPTIST UNIVERSITY   (United States)

^c BioKin Ltd   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CATALYTIC OXIDATION; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; MOLECULES; PORPHYRINS; SUBSTRATES;

ACTIVE SITES; BINDING ORIENTATIONS; CATALYTIC SITES; COMPUTATIONAL DOCKING; EFFECTOR SITES; HEME IRONS; HOMOLOGY MODELS; INDAZOLE; INHIBITION CONSTANTS; INHIBITION MECHANISMS; MECHANISTIC INTERPRETATIONS; MONOCYCLIC COMPOUNDS; NARROW CHANNELS; NITROPHENOL; POTENT INHIBITORS; SUBSTRATE CONCENTRATIONS; SUBSTRATE INHIBITIONS; TYPE II;

BINDING SITES;

4 METHYLPYRAZOLE; 4 NITROPHENOL; CYTOCHROME P450 2E1; INDAZOLE DERIVATIVE; ENZYME INHIBITOR; OXYGEN;

ARTICLE; CATALYSIS; ENZYME INHIBITION; LIPID OXIDATION; MICHAELIS MENTEN KINETICS; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; SEQUENCE HOMOLOGY; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG ANTAGONISM; ENZYME SPECIFICITY; HUMAN; KINETICS; METABOLISM;

BINDING SITES; CATALYSIS; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; INDAZOLES; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OXYGEN; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

EID: 41249084268     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707630200     Document Type: Article

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